公开(公告)号：EP1371724B1

公开(公告)日：2008-10-15

申请号：EP02705116.8

申请日：2002-03-13

申请人： TAKARA BIO INC.

发明人： SHIMOJO, Tomoko ,  TAKAKURA, Hikaru ,  OCHIAI, Kazuyori ,  ASADA, Kiyozo ,  KATO, Ikunoshin

IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K14/195

摘要： Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS:1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in gram positive bacteria.

公开(公告)号：EP1921136A1

公开(公告)日：2008-05-14

申请号：EP06796333.0

申请日：2006-08-10

申请人： Takara Bio, Inc.

发明人： CHONO, Hideto ,  MATSUMOTO, Kazuya ,  MINENO, Junichi ,  KATO, Ikunoshin

IPC分类号： C12N15/00 ,  A61K31/7088 ,  A61K35/76 ,  A61K48/00 ,  A61P31/18 ,  A61P43/00 ,  C12N5/10 ,  C12N15/09

CPC分类号： C12N15/86 ,  A61K31/7088 ,  A61K35/17 ,  A61K38/00 ,  A61K38/465 ,  A61K48/00 ,  C07K14/4702 ,  C12N5/0636 ,  C12N9/22 ,  C12N15/85 ,  C12N2510/00 ,  C12N2830/002 ,  Y02A50/473

摘要： A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.

摘要翻译： 一种核酸，其包含转录调控序列，其转录由人免疫缺陷病毒的反式作用因子和编码具有对单链RNA特异性的内切核糖核酸酶活性的多肽的基因所诱导，其中所述基因位于 该基因的表达可以通过转录调节序列调节; 一种在其中显示抑制人体免疫缺陷病毒复制的细胞的制备方法，所述方法包括将核酸引入细胞的步骤; 以及用于治疗或预防人类免疫缺陷病毒感染的方法。

公开(公告)号：EP1243651B1

公开(公告)日：2008-02-20

申请号：EP00985852.3

申请日：2000-12-25

申请人： TAKARA BIO INC.

发明人： KANAMORI, Akira ,  KINOSHITA, Masato ,  TAKASHIMA, Ryokichi ,  CHONO, Hideto ,  MIZUTANI, Shigetoshi ,  KONDO, Akihiro, 101, Hamoparesu-Kusatsu ,  KATO, Ikunoshin

IPC分类号： C12N15/11 ,  C12Q1/68 ,  A01K61/00 ,  C07K14/46 ,  A01K67/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/85 ,  G01N33/00

CPC分类号： C07K14/461

摘要： Killifish genes which are expressed specifically to females in accordance with the phenotype sex, characterized by having a base sequence selected from among the base sequences represented by SEQ ID NOS:1 to 21 in Sequence Listing.

公开(公告)号：EP1163912B1

公开(公告)日：2007-10-31

申请号：EP00908055.7

申请日：2000-03-14

申请人： TAKARA BIO INC.

发明人： KATO, Ikunoshin ,  ASADA, Kiyozo ,  UENO, Mitsuhiro ,  HASHINO, Kimikazu ,  YOSHIOKA, Hirofumi, 311, Hamoparesu-Kusatsu ,  TANAKA, Keiji

IPC分类号： A61K48/00 ,  A61K38/00

CPC分类号： A61K48/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2740/13043 ,  C12N2810/40

摘要： Gene therapeutics to be used in treating diseases showing sensitivity to gene therapy, characterized by containing as the active ingredient an efficacious amount of a functional substance which has a function of having an affinity for a virus containing a gene usable in the gene therapy and another function of having an affinity specific for a target cell with a need for the gene transfer, or an efficacious amount of a functional substance which has an affinity for the above virus and an efficacious amount of another functional substance which has an affinity specific for the above cell.

公开(公告)号：EP1226826B1

公开(公告)日：2007-07-18

申请号：EP00953450.4

申请日：2000-08-17

申请人： TAKARA BIO INC.

发明人： TOMINAGA, Takanari ,  YAMASHITA, Syusaku ,  MIZUTANI, Shigetoshi ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： A61K31/737 ,  A61K36/02 ,  A61K35/56 ,  A61P37/02 ,  A61P43/00 ,  A61P37/08 ,  C08B37/00

CPC分类号： A61K31/737 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/7024 ,  A61K36/03 ,  A23V2250/202 ,  A23V2250/2042 ,  A23V2250/51

摘要： Remedies or preventives for diseases with a need for the regulation of the production of cytokines, diseases with a need for the production of nitrogen monoxide or allergic diseases characterized by containing as the active ingredient fucoidan and/or its decomposition product; and foods, drinks or feeds for regulating the production of cytokines, foods, drinks or feeds for inducing the production of nitrogen monoxide, antiallergic foods, drinks or feeds, etc. containing fucoidan and/or its decomposition product.

摘要翻译： 需要调节细胞因子产生的疾病，需要产生一氧化氮的疾病或以含有作为活性成分的岩藻依聚糖和/或其分解产物为特征的过敏性疾病的疾病的补救或预防; 以及用于调节细胞因子产生的食物，饮料或饲料，用于诱导产生含有岩藻依聚糖和/或其分解产物的一氧化氮，抗过敏食物，饮料或饲料等的食物，饮料或饲料。

公开(公告)号：EP1156104B1

公开(公告)日：2007-04-11

申请号：EP00904063.5

申请日：2000-02-21

申请人： TAKARA BIO INC.

发明人： TOMONO, Jun ,  NOMURA, Yoshiko ,  SAGAWA, Hiroaki, 503, Hamoparesu-Kusatsu ,  SAKAI, Takeshi, 203, Raionzumanshon-Shinakawamachi ,  KATO, Ikunoshin

IPC分类号： C12N9/40 ,  C12N15/56 ,  C12P19/14

CPC分类号： C12Y302/01158 ,  C12N9/2465 ,  C12P19/04 ,  C12P19/24

摘要： α-Agarase having the following physicochemical properties: (1) function: hydrolyzing an α-1,3 bond between 3,6-anhydro-L-galactose and D-galactose; (2) substrate specificity: acting on agarose and agarohexaose and higher agarooligosaccharides but not on agarotetraose; (3) optimum temperature: showing its enzymatic activity at 55 °C or below; and (4) heat stability: sustaining 20% or more of the activity after being treated at 48 °C for 30 seconds.

公开(公告)号：EP1094114B1

公开(公告)日：2007-01-03

申请号：EP99926821.2

申请日：1999-06-25

申请人： TAKARA BIO INC.

发明人： UENO, Mitsuhiro ,  YOSHIOKA, Hirofumi ,  KONISHI, Haruko 407, Gurankoto-Rakuyo ,  HASHINO, Kimikazu ,  MORISHITA, Mio ,  CHONO, Hideto ,  MIYAMURA, Tsuyoshi ,  SANO, Mutsumi ,  ASADA, Kiyozo ,  FUJINAGA, Kei ,  KATO, Ikunoshin

IPC分类号： C12N15/86 ,  C07K14/78 ,  C12N15/87

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2810/10 ,  C12N2810/80 ,  C12N2810/851 ,  C12N2810/859

摘要： Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on a carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or a mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to activate transfferin receptor; or introducing a new functional group into the functional substance.

公开(公告)号：EP1715037A1

公开(公告)日：2006-10-25

申请号：EP04820173.5

申请日：2004-12-06

申请人： TAKARA BIO INC.

发明人： UEMORI, Takashi ,  TAKEDA, Osamu ,  YAMAMOTO, Junko ,  MUKAI, Hiroyuki ,  ASADA, Kiyozo ,  KATO, Ikunoshin

IPC分类号： C12N15/00 ,  C12Q1/68

CPC分类号： C12Q1/6844 ,  C12Q2531/119 ,  C12Q2525/185 ,  C12Q2537/143 ,  C12Q2525/161

摘要： In the case where a template nucleic acid has sequences substantially the same as each other, a primer is designed in a region between these sequences so as to give a product in a ladder structure in which a target region is polymerized in a single sequence via the same sequences in the ICAN reaction. By using a chimeric oligonucleotide primer and a ladder-forming oligonucleotide primer containing a specific base sequence, an amplification product having a ladder structure can be positively formed and thus the sensitivity, amplification efficiency and reaction speed in the ICAN reaction can be elevated.

摘要翻译： 在模板核酸具有彼此基本相同的序列的情况下，在这些序列之间的区域中设计引物，以便产生梯形结构中的产物，其中靶区域通过经由 在ICAN反应中相同的序列。 通过使用嵌合寡核苷酸引物和含有特定碱基序列的梯形寡核苷酸引物，可以积极地形成具有梯形结构的扩增产物，从而提高ICAN反应中的灵敏度，扩增效率和反应速度。

公开(公告)号：EP0955366B1

公开(公告)日：2006-09-06

申请号：EP96941211.3

申请日：1996-12-10

申请人： TAKARA BIO INC.

发明人： TAKESAKO, Kazutoh ,  OKADO, Takashi ,  YAGIHARA, Tomoko ,  KURODA, Masanobu ,  ONISHI, Yoshimi ,  KATO, Ikunoshin ,  AKIYAMA, Kazuo ,  YASUEDA, Hiroshi ,  YAMAGUCHI, Hideyo

IPC分类号： C12N15/31 ,  C07K14/37 ,  C07K16/14 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/00 ,  A61K39/395

CPC分类号： A61K39/0002 ,  A61K38/00 ,  A61K39/00 ,  C07K14/37 ,  C07K16/14 ,  Y10S530/858

摘要： A substantially pure, isolated antigenic protein originating in fungi of the genus Malassezia, characterized by having an avidity with IgE antibodies originating in allergic patients; antigenic fragments originating in said protein; a specific antibody against said antigenic protein or fragments; a diagnostic, therapeutic or prophylactic agent for malassezian allergic diseases containing the antigenic protein or fragments as the active ingredient; a novel recombinant malassezian antigenic protein; a gene coding for the protein; and epitopes of the protein.

公开(公告)号：EP1313458B1

公开(公告)日：2006-04-19

申请号：EP01964501.9

申请日：2001-08-29

申请人： TAKARA BIO INC.

发明人： INOUYE, Masayori ,  PHADTARE, Sangita ,  YAMANAKA, Kunitoshi ,  KATO, Ikunoshin

IPC分类号： A61K31/12 ,  C12N5/00 ,  C07K14/245

CPC分类号： C07K14/245 ,  Y02A50/473

摘要： The invention relates to a gene isolated from E. coli, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.