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    Portable equipment comprising generator circuit and provider for therapeutic transfer of molecules by electroporation
    71.
    发明公开
    Portable equipment comprising generator circuit and provider for therapeutic transfer of molecules by electroporation 审中-公开
    便携式设备与发生器电路和实用程序通过电穿孔分子的治疗转移

    公开(公告)号：EP2221086A1

    公开(公告)日：2010-08-25

    申请号：EP09002599.0

    申请日：2009-02-24

    申请人： Spugnini, Enrico

    发明人： Spugnini, Enrico ,  Baldi, Alfonso ,  Aiello, Lorenzo ,  Mudrov, Nikolay ,  Daskalova, Marina ,  Dotsinsky, Yvan

    IPC分类号： A61N1/32

    CPC分类号： A61N1/327

    摘要： The present invention aims to address at least partially the above issues in a much more versatile configuration that will allow more efficient and safer procedures in a broader spectrum of clinical conditions compared to the other electroporators.
    To reach this purpose, a portable equipment for therapeutic transfer of molecules according to the invention comprises electroporation protocol means to control biphasic pulses sequences with a parameters set comprising the number of pulses in each sequence, bipolar shape and duration of each pulse component as well as pause duration between two sequences, means to download said parameters preliminary determined as depending of the transfer protocol. The pulses are provided by a circuit comprising a rechargeable battery that powers a capacitor to generate a burst of biphasic pulses to electrodes at a high voltage, requiring only a control on the voltage of the generated pulses.

    摘要翻译： 本发明旨在解决至少部分地在一个更灵活的配置上述问题thatwill允许在相比于其他电穿孔的临床病症具有更广谱更有效和更安全的程序。 为了达到这个目的，雅丁分子的治疗性传递给本发明的便携式设备包括电穿孔方案的手段来控制两相脉冲序列与一个参数集包括每个序列，双极形状，并且每个脉冲分量的持续时间中的脉冲的数量以及 打破两个序列之间的持续时间，意味着下载所述参数初步确定性开采作为传输协议，这取决于。 这些脉冲由包括可再充电电池功率并电容器在高电压，以产生两相脉冲电极的突发，只需要对所生成的脉冲的电压的控制的电路来提供。

    Microperfusive electrical stimulation
    77.
    发明公开
    Microperfusive electrical stimulation 审中-公开
    组合电刺激和微灌

    公开(公告)号：EP1588736A3

    公开(公告)日：2009-03-11

    申请号：EP05252474.1

    申请日：2005-04-20

    申请人： Zoll Medical Corporation

    发明人： Freeman, Gary A.

    IPC分类号： A61N1/362

    CPC分类号： A61N1/327 ,  A61N1/362 ,  A61N1/3906 ,  A61N1/3962

    摘要： A method of treating a patient in cardiac arrest (e.g., in fibrillation, electrochemical dissociation, or asystole), the method comprising delivering an agent for enhancement of cardiac function to the coronary arteries of the patient; and microperfusing the patient's cardiac tissue by electromagnetically stimulating the cardiac tissue at an energy level below a threshold sufficient to defibrillate the heart.

    HIGH IMPEDANCE SYSTEM FOR GENERATING ELECTRIC FIELDS AND METHOD OF USE
    79.
    发明公开
    HIGH IMPEDANCE SYSTEM FOR GENERATING ELECTRIC FIELDS AND METHOD OF USE 有权
    高阻于产生电场和使用方法体系

    公开(公告)号：EP1952133A1

    公开(公告)日：2008-08-06

    申请号：EP06827315.0

    申请日：2006-10-31

    申请人： May-Ruben Technologies, Inc.

    发明人： MAY, Wayne, A. ,  RUBEN, Peter

    IPC分类号： G01N27/02

    CPC分类号： A61N1/042 ,  A61N1/0424 ,  A61N1/327 ,  H05H1/2406 ,  H05H2001/2456

    摘要： Disclosed is a system and method for generating time variant and invariant electric fields (E-fields) for various applications. Generating the E-field utilizes high impedance dielectric materials having a collection of three imperative material properties: high permittivity (ϵ), high volume resistivity (ρ) and high maximum allowable E-field stress (φ) and physical geometries that take advantage of the manner in which E-fields are divided or distributed in series capacitance networks. The generated E-field can act upon a subject material, including a gas, liquid or solid, wherein the material is stationary or in motion. The method allows an E-field of given intensity to be set up in the subject material with a significantly lower applied voltage Φa, or conversely, a significantly higher E-field intensity with a given applied voltage Φa. The method forestalls electric conduction current through the subject material, thus significantly reducing electric conduction current, energy consumption, ohmic heating, and preempting electrochemical reactions at the electrode/fluid interfaces. Acoustic energy may also be applied.

    METHOD OF TREATING BIOLOGICAL MATERIALS WITH TRANSLATING ELECTRICAL FIELDS AND ELECTRODE POLARITY REVERSAL
    80.
    发明授权
    METHOD OF TREATING BIOLOGICAL MATERIALS WITH TRANSLATING ELECTRICAL FIELDS AND ELECTRODE POLARITY REVERSAL 有权
    方法将生物材料有译END电场和电极的极性反转处理

    公开(公告)号：EP1494752B1

    公开(公告)日：2008-07-30

    申请号：EP03719469.3

    申请日：2003-04-11

    申请人： Cyto Pulse Sciences, Inc.

    发明人： WALTERS, Richard, E. ,  KING, Alan, D. ,  DEBRUIN, Katherine, A.

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0412 ,  A61N1/0476 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327

    摘要： A method and apparatus are provided for treating biological cellular material with a treating agent using pulsed electrical fields provided by a waveform generator (12). The treatment method includes obtaining an electrode assembly which includes three or more parallel rows of individual electrodes (19). The electrode assembly is applied to a treatment area. Electrically conductive pathways are established between the electrodes (19) and the waveform generator (12) through an array switch (14). Successive electric fields are applied to the treatment area in the form of successive electric field waveforms from the waveform generator (12), through the array switch (14), to adjacent rows of electrodes (19), wherein each successive electric field has the same direction, and wherein polarities of rows of electrodes are reversed successively during the applying of the successive electric fields between adjacent successive rows of electrodes to the treatment area. As a result, the biological cellular material in the treatment area is treated with the treating agent unidirectionally with uniform electric fields with a minimization of the formation of deleterious electrochemistry products at the electrodes.