公开(公告)号：EP1827078A4

公开(公告)日：2009-11-11

申请号：EP05854682

申请日：2005-12-19

申请人： MONSANTO TECHNOLOGY LLC

发明人： LUND ADRIAN

IPC分类号： C12N15/82 ,  A01H5/00 ,  C07K14/415

CPC分类号： C12N15/8216 ,  A01G1/001 ,  A01H1/02 ,  A01H1/04 ,  C07K14/415 ,  C12N9/0004 ,  C12N9/1029 ,  C12N9/1092 ,  C12N15/8247 ,  C12N15/8251 ,  C12N15/8261 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/8274 ,  C12N15/8275 ,  C12N15/8282 ,  C12N15/8283 ,  Y02A40/146

摘要： This disclosure describes screening a population of transgenic plants derived from plant cells transformed with recombinant DNA for expression of proteins with homeobox domains to identify plant cells of specific transgenic events that are useful for imparting enhanced traits to transgenic crop plants. Traits include enhanced nitrogen use efficiency, increased yield, enhanced water use efficiency, enhanced tolerance to cold stress and/or improved seed compositions. Also disclosed are transgenic seeds for growing a transgenic plant having the recombinant DNA in its genome and exhibiting the screened enhance trait. Also disclosed are methods for generating seed and plants based on the transgenic events.

公开(公告)号：EP2100963A1

公开(公告)日：2009-09-16

申请号：EP09004155.9

申请日：1999-07-06

申请人： DCV Inc. doing business as Bio-Technical Resourses

发明人： Millis, James R. ,  Saucy, Gabriel G. ,  Maurina-Brunker, Julie ,  McMullin, Thomas W.

IPC分类号： C12P1/02 ,  C07C45/41 ,  C07D303/04 ,  C07D311/72

CPC分类号： C12P7/04 ,  C07C403/08 ,  C07C403/24 ,  C07C2601/16 ,  C07D311/72 ,  C12N9/0004 ,  C12N9/1085 ,  C12P9/00 ,  C12P17/06 ,  C12P23/00 ,  H01Q1/00

摘要： The invention relates to methods for producing farnesol or geranylgeraniol comprising: (a) culturing a microorganism in a fermentation medium to produce a product selected from the group consisting of farnesyl phosphate and farnesol or geranylgeranyl phosphate and geranylgeraniol, wherein the action of squalene synthase of said microorganism is reduced; and (b) recovering said product.

摘要翻译： 本发明涉及生产法呢醇或香叶基香叶醇的方法，包括：（a）在发酵培养基中培养微生物以产生选自法呢基磷酸酯和法呢醇或香叶基香叶基磷酸酯和香叶基香叶醇的产物，其中所述 微生物减少; 和（b）回收所述产品。

公开(公告)号：EP2076591A2

公开(公告)日：2009-07-08

申请号：EP07861465.8

申请日：2007-10-19

申请人： Danisco US, Inc., Genencor Division

发明人： KUMAR, Manoj ,  MCDONALD, Hugh C. ,  POULOSE, Ayrookaran J. ,  RAND, Thomas ,  WANG, Huaming ,  MADRID, Susan

IPC分类号： C12N9/04 ,  C12N15/62 ,  C12N15/53 ,  C11D3/386

CPC分类号： C12N9/0006 ,  C07K2319/00 ,  C07K2319/02 ,  C11D3/38636 ,  C11D3/38654 ,  C12N9/0004 ,  C12N9/0069

摘要： The present invention provides compositions and methods for producing a polyol oxidase in micoroorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and cleaning compositions that contain combinations of two or more POx oxidases and a perhydrolase. In particular, the invention provides methods for expressing polyol oxidases in bacterial hosts for use in detergent applications for cleaning, bleaching and disinfecting.

公开(公告)号：EP2010559A1

公开(公告)日：2009-01-07

申请号：EP07728501.3

申请日：2007-04-25

申请人： DSM IP Assets B.V.

发明人： BOVENBERG, Roelof Ary Lans ,  VAN DEN BERG, Marco Alexander ,  HAGE, Suzanne ,  KLAASSEN, Paul ,  MEIJRINK, Bernard ,  RAAMSDONK, Lourina Madeleine

IPC分类号： C07K14/385 ,  C12N1/16

CPC分类号： C12N9/1029 ,  C12N9/0004 ,  C12N9/93 ,  C12P7/02 ,  C12P13/02 ,  C12P17/06 ,  C12P17/181 ,  C12P17/182 ,  C12P17/188

摘要： The present invention provides a recombinant Penicillium chrysogenum strain characterized in that a gene selected from the list consisting of penDE, pcbAB and pcbC is inactivated and the use of such a strain for the preparation of a compound of interest. Furthermore, it is an object of the present invention to provide a method for the production of a compound of interest in a eukaryotic recombinant microorganism comprising the steps of : (a) Reducing the level of secondary metabolite production in said microorganism with 50-100%; (b) Introducing a heterologous gene into said microorganism

公开(公告)号：EP1947189A2

公开(公告)日：2008-07-23

申请号：EP08003596.7

申请日：1999-07-06

申请人： DCV Inc. doing business as Bio-Technical Resourses

发明人： Millis, James R. ,  Saucy, Gabriel G. ,  Maurina-Brunker, Julie ,  McMullin, Thomas W.

IPC分类号： C12P1/02 ,  C07C45/41 ,  C07D303/04 ,  C07D311/72

CPC分类号： C12P7/04 ,  C07C403/08 ,  C07C403/24 ,  C07C2601/16 ,  C07D311/72 ,  C12N9/0004 ,  C12N9/1085 ,  C12P9/00 ,  C12P17/06 ,  C12P23/00 ,  H01Q1/00

摘要： The invention provides a method of producing α-tocopherol and α-tocopheryl esters and a method of producing vitamin A or β-carotene. The methods comprise using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into α-tocopherol, an α-tocopheryl ester, vitamin A or β-carotene.

摘要翻译： 本发明提供了生产± - 生育酚和± - 生育酚酯的方法以及生产维生素A或β-胡萝卜素的方法。 该方法包括使用生物系统来生产法呢醇或香叶基香叶醇。 然后，法呢醇或香叶基甘露醇化学转化为±生育酚，一个生育酚酯，维生素A或β-胡萝卜素。

公开(公告)号：EP1103612B1

公开(公告)日：2008-03-26

申请号：EP99935047.3

申请日：1999-08-04

申请人： MERCIAN CORPORATION

发明人： FUJII, Tadashi ,  NARITA, Takao ,  NAKATA, Kuniho ,  AGEMATU, Hitosi ,  TSUNEKAWA, Hiroshi ,  ISSHIKI, Kunio ,  YOSHIOKA, Takeo

IPC分类号： C12N15/53 ,  C12N15/54 ,  C12N9/04 ,  C12N9/10 ,  C12N1/21 ,  C12P13/04

CPC分类号： C12N9/0004 ,  C12N9/00 ,  C12N9/1096 ,  C12P13/14

公开(公告)号：EP1826265A3

公开(公告)日：2008-02-13

申请号：EP07005020.8

申请日：1999-10-06

申请人： ARBORGEN, LLC

发明人： Bloksberg, Leonard Nathan ,  Havukkala, Ilkka Jaakko

IPC分类号： C12N9/00 ,  C12N9/02 ,  C12N9/08 ,  C12N9/10 ,  C12N9/32 ,  C12N9/42 ,  C12N9/86 ,  C12N15/82

CPC分类号： C12N9/0004 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0059 ,  C12N9/0061 ,  C12N9/0065 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1011 ,  C12N9/1051 ,  C12N9/2422 ,  C12N9/2445 ,  C12N9/86 ,  C12N9/93 ,  C12N15/8255 ,  C12Y110/03001 ,  C12Y110/03002 ,  C12Y114/13011 ,  C12Y201/01006 ,  C12Y302/01001 ,  C12Y302/01021

摘要： Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.

公开(公告)号：EP1148122A4

公开(公告)日：2008-02-13

申请号：EP00901980

申请日：2000-01-28

申请人： KYOWA HAKKO KOGYO KK

发明人： ENDO HIROFUMI ,  YONETANI YOSHIYUKI ,  MIZOGUCHI HIROSHI ,  HASHIMOTO SHIN-ICHI ,  OZAKI AKIO

IPC分类号： C07K14/32 ,  C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/62 ,  C12P17/06

CPC分类号： C12N9/0004 ,  C07K14/32 ,  C12P7/62 ,  C12P17/06

摘要： A protein having an activity of hydroxylating compounds originating in a microorganism belonging to the genus Bacillus and represented by general formula (I-a) or lactones formed by cyclizing these compounds; a DNA encoding this protein; a recombinant DNA containing this DNA; etc.; in formula (I-a) R1 represents hydrogen, optionally substituted alkyl or an alkali metal; and R2 represents optionally substituted alkyl or optionally substituted aryl.

公开(公告)号：EP1848800A2

公开(公告)日：2007-10-31

申请号：EP06723019.3

申请日：2006-02-10

申请人： DSM IP Assets B.V.

发明人： CHEVREUX, Bastien ,  GELDER VAN, Marina ,  HAUK, Corina ,  KOEKMAN, Bertus Pieter ,  MEURY, Anja ,  MOUNCEY, Nigel, John ,  SCHIPPER, Dick ,  SHINJOH, Masako ,  VOLLEBREGT, Adrianus Wilhelmus Hermanus

IPC分类号： C12N15/09 ,  C07K14/195

CPC分类号： C12N9/0004 ,  C12N9/0034 ,  C12Y105/03001

摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

摘要翻译： 本发明涉及编码参与L-抗坏血酸合成的蛋白质（以下也称为维生素C）的新鉴定的基因。 本发明的特征还在于包含新基因及其片段的全长多核苷酸序列的多核苷酸，由该多核苷酸及其片段编码的新多肽以及它们的功能等价物。 本发明还涉及所述多核苷酸和多肽作为生物技术工具在由微生物生产维生素C中的用途，由此修饰所述多核苷酸和/或编码的多肽对产量，产量和/或 所述微生物中发酵产物的生产效率。 还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/过程。 本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

公开(公告)号：EP1841876A2

公开(公告)日：2007-10-10

申请号：EP06733682.6

申请日：2006-01-11

申请人： PIONEER HI-BRED INTERNATIONAL, INC. ,  E.I. DUPONT DE NEMOURS AND COMPANY

发明人： DIEHN, Scott ,  LU, Albert L. ,  MCCUTCHEN, Billy F. ,  SIMS, Lynne E. ,  WARD, Kim R.

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N9/0004 ,  C12N15/8227 ,  C12N15/8237 ,  C12N15/8239

摘要： The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for an inducible promoter for the gene encoding a maize deoxyhypusine synthase. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises stably incorporating into the genome of a plant cell a nucleotide sequence operably linked to the root-preferred promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.