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公开(公告)号：EP2572707A2
公开(公告)日：2013-03-27
申请号：EP12178688.3
申请日：2003-02-20
发明人： O'Hagan, Derek , Singh, Manmohan , Kazza, Jina
CPC分类号： A61K9/1647 , A61K9/1676 , A61K9/1694 , A61K39/02 , A61K39/095 , A61K39/39 , A61K47/6927 , A61K2039/55555 , A61K2039/6093 , C12N2730/10111 , C12N2760/16111
摘要： Microparticles with adsorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide-containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).
摘要翻译： 公开了在不使用表面活性剂的情况下形成的具有吸附的含多肽分子的微粒，制备这种微粒组合物的方法及其用途。 微粒包含聚合物，例如聚（α-羟基酸），聚羟基丁酸，聚己内酯，聚原酸酯，聚酐等。 优选的聚合物是聚（D，L-丙交酯 - 共 - 乙交酯），更优选具有40:60至60:40的丙交酯/乙交酯摩尔比并且具有20,000道尔顿至70,000道尔顿的分子量的那些。 优选的含有多肽的分子是细菌和病毒抗原（包括HIV抗原，脑膜炎B抗原，链球菌B抗原和甲型流感血凝素抗原）。
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公开(公告)号：EP1232267B1
公开(公告)日：2013-03-20
申请号：EP00973922.8
申请日：2000-10-27
发明人： Paliard, Xavier , Houghton, Michael , Selby, Mark
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C07K2319/00 , C12N2770/24222
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83.发明授权IDENTIFICATION OF OLIGONUCLEOTIDES FOR THE CAPTURE, DETECTION AND QUANTITATION OF HEPATITIS A VIRAL NUCLEIC ACID 有权TO ERFASSSEN寡核苷酸的确定，A型肝炎病毒NUCLEIC检测和定量
公开(公告)号：EP1552022B1
公开(公告)日：2013-01-23
申请号：EP03741986.8
申请日：2003-06-12
CPC分类号： C12Q1/706 , C12Q1/703 , Y02A50/54 , C12Q2563/107 , C12Q2545/114 , C12Q2525/15 , C12Q2563/143
摘要： Hepatitis A virus-specific primers and probes derived from conserved regions of the hepatitis A virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.
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公开(公告)号：EP1372528B1
公开(公告)日：2013-01-02
申请号：EP02763972.3
申请日：2002-04-05
IPC分类号： A61K39/00 , A61K39/02 , A61K39/09 , A61K39/095 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/155 , A61K39/21 , A61K39/245 , A61K39/29 , A61K39/295 , A61K47/34 , A61K47/42 , A61K47/48 , A61K48/00 , C12N15/09
CPC分类号： A61K39/385 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/1647 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/095 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6093 , C12N2740/16134 , Y02A50/464
摘要： Mucosal immunization using one or more antigens following parenteral administration of the same or different antigens is described.
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85.发明公开Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof 审中-公开编码C-的HIV型的多肽的多核苷酸，多肽和它们的使用
公开(公告)号：EP2412242A3
公开(公告)日：2012-06-13
申请号：EP11161076.2
申请日：2002-07-05
发明人： Zur Megede, Jan , Barnett, Susan W. , Lian, Ying , Engelbrecht, Susan , Van Rensburg, Estrelita Janse , Scriba, Thomas Jens
IPC分类号： A01N63/00 , A61K48/00 , C12N5/00 , C12N5/02 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C07H21/04 , C07K14/16 , C12N15/867 , C07K14/005 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2720/00034 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2799/027 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
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公开(公告)号：EP1618087B1
公开(公告)日：2012-06-13
申请号：EP04700887.5
申请日：2004-01-08
发明人： ANDERSON, Niels H. , BOWMAN, Jason , ERWIN, Alice , HARWOOD, Eric , KLINE, Toni , MDLULI, Khisimuzi , NG, Simon , PFISTER, Keith B. , SHAWAR, Ribhi , WAGMAN, Allan , YABANNAVAR, Asha
IPC分类号： C07C233/00 , A61K31/16 , A61K31/165 , A61P31/00 , A61P31/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：EP1858919B1
公开(公告)日：2012-04-04
申请号：EP06748227.3
申请日：2006-02-17
发明人： PIZZA, Mariagrazia, c/O CHIRON CORPORATION , SERINO, Laura, C/O CHIRON CORPORATION , BERLANDA SCORZA, Francesco, C/O CHIRON CORPORATION , FONTANA, Maria Rita , GOMES MORIEL, Danilo Novartis Vaccines
IPC分类号： C07K14/245 , A61K38/16
CPC分类号： C07K14/245 , A61K38/00 , Y02A50/473
摘要： Disclosed herein is a gene that can be included in immunogenic compositions specific for pathogenic E. coli strains. The gene is from uropathogenic strains but is absent from non-pathogenic strains, and its encoded protein has cellular locations which render it accessible to the immune system.
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公开(公告)号：EP2261348A3
公开(公告)日：2012-01-25
申请号：EP10178532.7
申请日：1999-04-30
发明人： Fraser, Claire , Galeotti, Cesira , Grandi, Guido , Hickey, Erin , Masignani, Vega , Mora, Marirosa , Petersen, Jeremy , Pizza, Mariagrazia , Rappuoli, Rino , Ratti, Giulio , Scarlato, Vincenzo , Scarselli, Maria , Tettelin, Hervé , Venter, J. Craig
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria mcningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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89.发明公开Method of determining the susceptibility to bone meatastases by EPhA2 expression 审中-公开用于确定骨的易感性的方法转移灶上的EphA2的表达
公开(公告)号：EP2266628A3
公开(公告)日：2012-01-18
申请号：EP10179730.6
申请日：2004-05-12
IPC分类号： A61K48/00 , C12Q1/68 , A61P35/00 , A61K31/663
CPC分类号： A61K31/663 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.
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公开(公告)号：EP2261355A3
公开(公告)日：2012-01-11
申请号：EP10178545.9
申请日：1999-04-30
发明人： Fraser, Claire , Galeotti, Cesira , Grandi, Guido , Hickey, Erin , Masignani, Vega , Mora, Marirosa , Petersen, Jeremy , Pizza, Mariagrazia , Rappuoli, Rino , Ratti, Giulio , Scarlato, Vincenzo , Scarselli, Maria , Tettelin, Hervé , Venter, J. Craig
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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