公开(公告)号：EP0502637A3

公开(公告)日：1992-10-28

申请号：EP92301465.8

申请日：1992-02-21

申请人： ZENECA LIMITED

发明人： Barth, Peter Thomas

IPC分类号： C12N15/63 ,  C12N15/68 ,  C07K15/00

CPC分类号： C07K14/535 ,  C07K14/415 ,  C12N15/635 ,  C12N15/70 ,  C12N15/71

摘要： The invention relates to vectors which include an inducible selection gene and a sequence which codes for a heterologous polypeptide. In a particular example the selection gene comprises the tet A and tet R genes. The vector may also include a sequence which is capable of conferring stability on the vector, such as the cer sequence, a transcription terminator, such as gene 32 from bacteriophage T4, a ribosome binding site, and a multi-cloning site. Hosts transformed with the vector, processes for preparing these hots, and processes for preparing polypeptides using these hosts.

公开(公告)号：EP0183071A2

公开(公告)日：1986-06-04

申请号：EP85113737.2

申请日：1985-10-29

申请人： PHILLIPS PETROLEUM COMPANY

发明人： Stroman, David Womack ,  Brust, Paul Frederick ,  Ellis, Steven Bradley ,  Gingeras, Thomas Raymond ,  Harpold, Michael Miller ,  Tschopp, Juerg Friedrich

IPC分类号： C12N15/15 ,  C12N15/68 ,  C12N15/70

CPC分类号： C12N9/0006 ,  C12N15/52 ,  C12N15/68 ,  C12N15/70 ,  C12N15/815

摘要： Novel DNA sequences which are responsive to the presence of methanol, catabolite non-repressing carbon sources and carbon source starvation are provided. In addition, novel constructs including these DNA sequences, as well as transformed organisms therewith are provided. Processes for producing the DNA sequences and constructs of the invention are detailed. The production of polypeptide product under the control of the regulatory regions of the invention is demonstrated.

公开(公告)号：EP4416274A2

公开(公告)日：2024-08-21

申请号：EP22803413.8

申请日：2022-10-14

申请人： BioNTech SE

发明人： ROONEY, Michael Steven ,  LIU, Yunpeng ,  ESAULOVA, Ekaterina ,  ADDONA, Theresa ,  GAYNOR, Richard B. ,  PORAN, Asaf ,  GOULDING, Scott ,  KIRSCH, Miles ,  STOPFER, Lauren

IPC分类号： C12N7/00 ,  A61P31/14 ,  A61P31/22 ,  C12N15/67 ,  C12N15/68 ,  A61K39/12 ,  A61K39/25 ,  A61K39/245 ,  A61K39/125

CPC分类号： C12N7/00 ,  C12N2710/1673420130101 ,  C12N2710/1613420130101 ,  C12N2710/1603420130101 ,  A61K2039/5320130101 ,  A61P31/14 ,  A61P31/22 ,  Y02A50/30

公开(公告)号：EP4196140A1

公开(公告)日：2023-06-21

申请号：EP21856859.0

申请日：2021-08-16

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： LU, Zheng-Rong ,  SUN, Wenyu ,  SUN, Da

IPC分类号： A61K35/76 ,  A61K48/00 ,  A61P27/02 ,  C12N9/12 ,  C12N15/68

公开(公告)号：EP4150098A1

公开(公告)日：2023-03-22

申请号：EP21728609.5

申请日：2021-05-14

申请人： Oxford BioMedica (UK) Limited

发明人： RAPOSO, Rui Andre Saraiva ,  MOORE-KELLY, Charles ,  WRIGHT, Jordan ,  FARLEY, Daniel

IPC分类号： C12N15/68 ,  C12N15/86

公开(公告)号：EP4110406A1

公开(公告)日：2023-01-04

申请号：EP21760035.2

申请日：2021-02-28

申请人： Blueallele, LLC

发明人： BALTES, Nicholas

IPC分类号： A61K48/00 ,  C12N15/10 ,  C12N15/67 ,  C12N15/68

公开(公告)号：EP2514758B2

公开(公告)日：2021-06-23

申请号：EP12174021.1

申请日：2005-03-15

发明人： Rossi, John J. ,  Behlke, Mark A. ,  Kim, Dongho

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12N15/11 ,  C12N15/68 ,  C12N15/63 ,  C12N15/113

公开(公告)号：EP3741859A1

公开(公告)日：2020-11-25

申请号：EP20171676.8

申请日：2013-02-15

申请人： CureVac AG

发明人： THEß, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

IPC分类号： C12N15/68 ,  A61K39/00 ,  A61K39/35 ,  C12N15/117 ,  A61P3/00 ,  A61P5/00 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  C12N15/63 ,  C12N15/67 ,  C12N15/85

摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein, particularly for the use in gene therapy. It also discloses its use for the preparation of a pharmaceutical composition, e.g. for use in gene therapy, particularly in the treatment of diseases which are in need of a treatment with a therapeutic peptide or protein, preferably as defined herein. The present invention further describes a method for increasing the expression of a peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.

公开(公告)号：EP3167059B1

公开(公告)日：2019-06-26

申请号：EP15738014.8

申请日：2015-07-06

申请人： BioNTech RNA Pharmaceuticals GmbH ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： EBERLE, Florian ,  SAHIN, Ugur ,  KUHN, Andreas ,  VALLAZZA, Britta ,  DIKEN, Mustafa

IPC分类号： C12N15/09 ,  C12N15/67 ,  C12N15/68

公开(公告)号：EP3404103A1

公开(公告)日：2018-11-21

申请号：EP18168859.9

申请日：2013-02-15

申请人： CureVac AG

发明人： THEß, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

IPC分类号： C12N15/68 ,  A61K39/00 ,  A61K39/35 ,  C12N15/117

CPC分类号： A61K39/0008 ,  A61K39/35 ,  A61K2039/53 ,  A61K2039/64 ,  C12N15/63 ,  C12N15/67 ,  C12N15/85

摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of allergies or autoimmune diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.