公开(公告)号：EP0637367A4

公开(公告)日：1995-08-16

申请号：EP93909177

申请日：1993-03-26

申请人： ABAY SA

发明人： CHATTERJEE BIKASH K ,  BUHL STEVEN N ,  YU CHI-SOU ,  TANG THUY N ,  SMITH GARY L ,  BHAYANI BHASKAR ,  ALVARADO ANTHONY ,  WONG SWEE

IPC分类号： F25D3/10 ,  A23L3/375 ,  A61J3/00 ,  A61J3/06 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42 ,  F17C7/04 ,  F24F3/16 ,  F25D13/06 ,  F25D25/02 ,  F26B13/30

CPC分类号： A23L3/375 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42

公开(公告)号：EP0626071A4

公开(公告)日：1995-01-25

申请号：EP93905829

申请日：1993-02-09

申请人： ABAY SA

发明人： BURD TAMMY L ,  SCHEMBRI CAROL T

IPC分类号： G01N33/48 ,  B04B5/00 ,  G01N21/07 ,  G01N33/49 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00 ,  B67D5/00

CPC分类号： G01N33/491 ,  G01N21/07 ,  G01N35/1002 ,  G01N2035/00495 ,  G01N2035/0405 ,  Y10T436/111666

公开(公告)号：EP0611323A4

公开(公告)日：1994-11-23

申请号：EP92923436

申请日：1992-10-27

申请人： ABAY SA

发明人： BRAYNIN BORIS ,  BURD TAMMY L ,  BUHL STEVEN N ,  SCHEMBRI CAROL T

IPC分类号： B04B5/02 ,  B01D17/038 ,  B01L3/00 ,  B01L3/14 ,  B04B5/04 ,  G01N1/10 ,  G01N1/28 ,  G01N21/07 ,  G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  B01D21/26

CPC分类号： B01L3/5021 ,  B01L3/502723 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0694 ,  B04B5/0407 ,  G01N21/07 ,  G01N33/491 ,  G01N2035/00237 ,  Y10T436/111666 ,  Y10T436/2575

摘要： An analytical rotor (10) for separating plasma from whole blood is made up of layers (12, 14) and (16) and has a blood application port (22) in layer (12) thereof. Blood introduced to the application port (22) is metered into a metering chamber (40) by capillary flow while the rotor (10) remains stationary. Excess blood passes into an overflow chamber (44) by capillary flow, either simultaneously with the flow to metering chamber (40) or later, after opening of vent passage connecting to overflow chamber (44). Subsequent rotation of the rotor (10) causes metered blood in the metering chamber (40) to flow into a separating chamber (60), typically retaining the separate plasma. A method of transferring a metered volume of fluid in rotor (10) is also disclosed.

公开(公告)号：EP3096784A4

公开(公告)日：2017-12-06

申请号：EP15740392

申请日：2015-01-21

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M ,  ROGERS ANDREW P ,  FORSYTH TIMOTHY P ,  WALKER JEREMY D ,  CUESICO CRISTINA R

IPC分类号： A61K39/02 ,  A61K38/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： G01N33/6854 ,  C07K14/195 ,  G01N33/56911 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the Anaplasma Outer Membrane Protein proteins. The invention also provides devices, methods, and kits comprising the populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens and the diagnosis of anaplasmosis. Methods of identifying the particular Anaplasma species infecting a subject using the peptide populations of the invention are also disclosed.

公开(公告)号：EP3126835A4

公开(公告)日：2017-10-11

申请号：EP15772535

申请日：2015-04-03

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  WALKER JEREMY D ,  ARON KENNETH P ,  BLEILE DENNIS M ,  CUESICO CRISTINA R ,  FORSYTH TIMOTHY P

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/12 ,  A61K39/38 ,  C12Q1/04 ,  G01N33/569

CPC分类号： G01N33/56911 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides methods, kits, compositions, and devices useful for detection of antibodies that bind to Ehrlichia antigens and/or for differentiation of certain Ehrlichia species from others. In particular, the invention provides methods and kits useful for identifying species of Ehrlichia using populations of isolated peptides.

公开(公告)号：EP2567339A4

公开(公告)日：2013-10-23

申请号：EP11778441

申请日：2011-05-06

申请人： ABAY SA

发明人： KAZMIERCZAK STEVE C

IPC分类号： G06F19/00

CPC分类号： G06Q50/22 ,  G16H10/40 ,  G16H50/70

摘要： Methods for determining the validity or accuracy of a clinical test result are provided. The methods entail obtaining patient analyte concentration data for two or more analytes with a concentration relationship; calculating a likelihood distribution for the concentration relationship between the two or more analytes; obtaining a clinical test result comprising measured concentration values for the two or more analytes; and determining the validity or accuracy of the clinical test result based on whether the clinical test result falls within the boundaries of the likelihood distribution. Analyte pairs that can be analyzed by the methods of the invention include albumin/calcium, sodium/chloride, BUN/creatinine, AST/ALT, total protein/albumin, potassium/total CO2, calcium/phosphorus, calcium/magnesium, potassium/creatinine, magnesium/potassium, Anion gap/potassium, sodium/potassium, chloride/potassium, magnesium/phosphate, ALT/GGT, ALT/ALP, CK/LDH and chloride/total CO2.

公开(公告)号：EP2906950A4

公开(公告)日：2016-05-25

申请号：EP13844762

申请日：2013-10-11

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M ,  FORSYTH TIMOTHY P ,  WALKER JEREMY D ,  CUESICO CRISTINA R

IPC分类号： G01N33/68 ,  C07K14/29 ,  C07K17/14 ,  G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54306 ,  C07K14/29 ,  C07K17/14 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions and mixtures comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic and/or granulocytic ehrlichiosis.

公开(公告)号：EP2583100A4

公开(公告)日：2013-11-06

申请号：EP11796504

申请日：2011-06-17

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P

IPC分类号： G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N35/00

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0806 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0409 ,  G01N33/558 ,  G01N33/581 ,  G01N33/587 ,  G01N35/00069

摘要： The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.

摘要翻译： 本发明提供了用于检测样品中的目标分析物的分析物检测系统。 特别地，本发明提供了一种转子或盘形式的检测系统，其利用离心力将样品移动通过检测系统。 还公开了使用转子检测系统来检测样品尤其是生物样品中的分析物的方法以及包括转子检测系统的套件。

公开(公告)号：EP1556688A4

公开(公告)日：2011-10-26

申请号：EP03809123

申请日：2003-10-17

申请人： ABAY SA

发明人： OSTOICH VLADIMIR E ,  ARON KENNETH ,  BLEILE DENNIS M

IPC分类号： G06F19/00 ,  C12Q1/00 ,  G01N31/00

CPC分类号： G16H10/40

摘要： Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteristics of a sample. These values are used in combination with reference data stored in a data module to generate a probability that the sample tested is a short sample, a long sample, or an acceptable sample. This probability and/or the status of the sample as a short sample, a long sample, or an acceptable sample are output to a user.

公开(公告)号：EP0641389A4

公开(公告)日：1996-11-20

申请号：EP92918083

申请日：1992-08-12

申请人： ABAY SA

发明人： BUHL STEVEN N ,  BOGART TERRI ,  BURD TAMMY ,  BHAYANI BHASKAR ,  SKIELLER CHRISTIAN ,  YU CHI-SOU ,  TANG THUY N ,  OSTOICH VLADIMIR E ,  HUC BRANKO ,  SCHEMBRI CAROL T

IPC分类号： C12Q1/32 ,  A61K9/16 ,  C12Q1/42 ,  G01N1/10 ,  G01N9/30 ,  G01N21/78 ,  G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/58 ,  G01N33/68 ,  G01N35/00 ,  B01D33/15 ,  B29B9/00

CPC分类号： G01N33/52 ,  A61K9/1694 ,  C12Q1/42 ,  G01N33/491 ,  G01N33/50 ,  G01N33/585 ,  G01N33/68 ,  Y10S436/805 ,  Y10S436/808 ,  Y10T436/10 ,  Y10T436/111666

摘要： The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also provided are diluents which are conveniently used in such analyzers.