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    USE OF A MIR172 MOLECULE FOR DECREASING INFLAMMATION
    2.
    发明公开
    USE OF A MIR172 MOLECULE FOR DECREASING INFLAMMATION 审中-公开
    VERWENDUNG EINES MIR172-MOLEKÜLSZUR LINDERUNG VONENTZÜNDUNGEN

    公开(公告)号：EP3035941A1

    公开(公告)日：2016-06-29

    申请号：EP14766010.4

    申请日：2014-08-13

    申请人： Instytut Biochemii i Biofizyki PAN ,  Uniwersytet Im. Adama Mickiewicza W Poznaniu

    发明人： LUKASIK, Anna ,  ZIELENKIEWICZ, Piotr ,  SZWEYKOWSKA-KULINSKA, Zofia ,  PACZEK, Leszek ,  NOWACZYK, Maria

    IPC分类号： A61K31/7088 ,  C12N15/113

    CPC分类号： C12N15/113 ,  C12N2310/141

    摘要： An exemplary embodiment relates to a method of using a plant-derived miR172 molecule or its synthetic equivalent, selected from amongst miR172a or miR172b, for decreasing inflammatory processes in an organism, a method of decreasing B and T lymphocyte proliferation, as well as a method of reducing protein FAN (Factor Associated with Neutral Sphingomyelinase Activation) level. Exemplary embodiments provide a novel therapeutic method based on miRNA molecules, which through the interaction with mRNA encoding FAN protein, negatively regulate its expression and decrease the inflammatory response of the organism.

    摘要翻译： 示例性实施方案涉及使用植物来源的miR172分子或其选自miR172a或miR172b的合成等价物以减少生物体内炎症过程的方法，降低B和T淋巴细胞增殖的方法，以及方法 的降低蛋白质FAN（与中性鞘磷脂酶激活相关的因子）水平。 示例性实施方案提供了基于miRNA分子的新型治疗方法，其通过与编码FAN蛋白的mRNA的相互作用负调节其表达并降低生物体的炎症反应。

    A recombinant DNA molecule, vector, plant cell and plant expression cassette producing large amounts of functionally active cysteine synthase and use thereof
    3.
    发明公开
    A recombinant DNA molecule, vector, plant cell and plant expression cassette producing large amounts of functionally active cysteine synthase and use thereof 审中-公开
    一种重组DNA分子，载体，植物细胞和植物表达盒，其产生大量的功能活性半胱氨酸合酶的，以及它们的使用

    公开(公告)号：EP2395088A1

    公开(公告)日：2011-12-14

    申请号：EP10179712.4

    申请日：2010-09-24

    申请人： Instytut Biochemii I Biofizyki Pan

    发明人： Liszewska, Frantz ,  Wawrzynska, Anna ,  Sirko, Agnieszka

    IPC分类号： C12N15/82 ,  C12N9/10

    CPC分类号： C12N15/8253 ,  C12N9/1085

    摘要： The present invention provides the means and the methods for obtaining plant materials producing large amounts of functionally active cysteine synthase (EC 2.5.1.47) that rely on an environment-friendly and health-safe enzyme production process for synthesis of L-cysteine and L-cystine, therefore suitably accounting among the c-GMP standards for production of the aforementioned compounds, namely of non-human and non-animal origin. Described is a recombinant DNA molecule comprising a nucleic acid molecule encoding a protein having cysteine synthase activity, wherein the said nucleic acid molecule is operably linked to regulatory elements allowing the expression of the nucleic acid molecule in plant cells. The present invention also provides a vector harboring the plant expression cassette comprising the said recombinant DNA molecule, as well as plant cells, plant tissues and plants transformed therewith. The present invention further describes the use of the aforementioned recombinant DNA molecule and vector in plant cell culture, plant tissue culture, and plant breeding; further presented are examples of the use of the said plant cells, plant tissues, plants, as well as the extracts from these plant raw materials for biosynthetic production of L-cysteine and/or L-cystine compounds being valuables in a broad range of applications, such as for production of additives or ingredients used in agroindustrial, cosmetic and pharmaceutic processes.

    摘要翻译： 本发明提供了一种方式，并获得规划教材生产功能性活性半胱氨酸合酶的大量方法（EC 2.5.1.47）做依靠，为L-半胱氨酸的合成环境友好和健康安全的酶制剂生产过程L- 胱氨酸，故适当的c GMP标准中占生产上述化合物的，即非人类和非动物来源。 描述了包含编码具有蛋白半胱氨酸合酶活性的核酸分子，所述worin所述核酸分子可操作地连接至允许在植物细胞中的核酸分子的表达的调控元件的重组DNA分子。 因此，本发明提供了一个载体携带植物表达盒包含所述重组DNA分子，以及规划细胞，植物组织，并用转化的有植物。 本发明还描述了使用在植物细胞培养物，植物组织培养物，和植物育种前述重组DNA分子和载体; 进一步呈现是利用所述植物细胞，植物组织，植物，以及从合成提取物规划原料生物合成生产L-半胱氨酸和/或L-胱氨酸化合物是贵重物品在宽范围的应用中的示例 ，：如用于生产农工业，化妆品和药用过程中使用的添加剂或成分。