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公开(公告)号：EP2908841A4
公开(公告)日：2016-05-25
申请号：EP13847205
申请日：2013-10-21
申请人： SCYNEXIS INC
发明人： LI KEQUIANG , PEEL MICHAEL ROBERT
CPC分类号： A61K38/21 , A61K38/00 , A61K38/13 , C07C229/48 , C07C271/24 , C07C317/14 , C07C321/28 , C07K7/645 , A61K2300/00
摘要： Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
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公开(公告)号：EP2663322A2
公开(公告)日：2013-11-20
申请号：EP12734728.4
申请日：2012-01-12
申请人： Scynexis, Inc.
CPC分类号： A61K38/13 , A61K38/14 , C12Q1/707 , C12Q2600/106 , C12Q2600/156 , Y02A50/463
摘要： Methods of predicting the response in a patient infected with hepatitis C virus (HCV) to a treatment regime involving the use of a cyclophilin-binding compound are described which provide for improvements in treatments, pharmaceutical compositions, dosing regimen, assays, kits, and other aspects of the art.
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公开(公告)号：EP2023918B1
公开(公告)日：2011-03-23
申请号：EP07795039.2
申请日：2007-05-18
申请人： Scynexis, Inc.
IPC分类号： A61K31/4025 , A61K31/4178 , A61K31/4453 , A61K31/496 , A61K31/5355 , A61K45/06 , A61K31/395 , A61P27/02
CPC分类号： A61K31/395 , A61K31/4025 , A61K31/4178 , A61K31/4453 , A61K31/496 , A61K31/5355 , A61K45/06
摘要： Provided herein are methods for treatment of ocular diseases. The methods comprise administering a compound of general Formula (I): wherein R1, R2, R3, R4 and Ak are as defined in the specification.
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4.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION 审中-公开方法和药物组合物用于治疗和预防丙型肝炎感染
公开(公告)号：EP1933859A2
公开(公告)日：2008-06-25
申请号：EP06816231.2
申请日：2006-10-02
申请人： Scynexis, Inc.
IPC分类号： A61K38/13
CPC分类号： A61K38/13 , A61K38/21 , A61K2300/00
摘要： This invention relates to cyclosporin derivatives of general formula (I): wherein A, B, R1, R2 and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus.
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公开(公告)号：EP1450925A1
公开(公告)日：2004-09-01
申请号：EP02804426.1
申请日：2002-11-19
申请人： Scynexis, Inc.
IPC分类号： B01D15/08
CPC分类号： B01D15/247 , G01N30/82 , G01N30/8668
摘要： The invention relates to methods of separating compounds of interest from mixtures using high performance liquid chromatography (HPLC). An initial separation of a sample of a mixture is performed to predict a retention time and elution time for the compound of interest on a preparative scale HPLC column and, optionally, to verify that an expected compound of interest is present in the mixture. Preparative scale HPLC is then used to separate and collect at least a portion of the compound from the mixture using the predicted elution time of the compound.
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公开(公告)号：EP3247711B1
公开(公告)日：2022-03-09
申请号：EP16703009.7
申请日：2016-01-14
发明人： ZHANG, Yi
IPC分类号： C07D405/14 , A61K31/4439 , A61P31/10
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公开(公告)号：EP3735226A1
公开(公告)日：2020-11-11
申请号：EP18834263.8
申请日：2018-12-21
申请人： Scynexis, Inc.
发明人： MOTHERAM, Rajeshwar
IPC分类号： A61K9/127 , A61K31/4196
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公开(公告)号：EP3609539A1
公开(公告)日：2020-02-19
申请号：EP18720489.6
申请日：2018-04-04
申请人： Scynexis, Inc.
IPC分类号： A61K45/06 , A61K31/4196 , A61K31/4439 , A61P31/10
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公开(公告)号：EP3247711A1
公开(公告)日：2017-11-29
申请号：EP16703009.7
申请日：2016-01-14
申请人： Scynexis, Inc.
发明人： ZHANG, Yi
IPC分类号： C07D405/14 , A61K31/4439 , A61P31/10
CPC分类号： C07J71/0005 , C07C59/265 , C07D405/14
摘要： SCY-078 is a glucan synthase inhibitor with antimicrobial activity. Novel salts and polymorph forms of SCY-078 are disclosed herein. The disclosure also relates to pharmaceutical compositions, methods of use, and methods of preparing the novel salts and polymorphs of SCY-078.
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公开(公告)号：EP2509615A1
公开(公告)日：2012-10-17
申请号：EP10796120.3
申请日：2010-12-09
申请人： Scynexis, Inc.
发明人： LI, Kequiang , PEEL, Michael Robert
摘要： Compounds are disclosed of general formula (I) wherein A, B, R
1 and R
2 are as defined in the description, and their use as pharmaceuticals.
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