公开(公告)号：EP2680821B1

公开(公告)日：2018-08-01

申请号：EP12719451.2

申请日：2012-03-03

申请人： Wroclawskie Centrum Badan EIT + SP Z O.O.

发明人： GUBERNATOR, Jerzy ,  KOZUBEK, Arkadiusz ,  PADUSZYNSKI, Piotr ,  LIPKA, Dominik

IPC分类号： A61K31/704 ,  A61K31/375 ,  A61K31/519 ,  A61K9/127 ,  A61K45/06

CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K31/375 ,  A61K31/519 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The subject of the present invention is a liposomal formulation containing an anti-tumour compound characterised in that it contains the active compound encapsulated in liposome vesicles forming a composition of lipid components in the ratio of 1 part by mass of the active compound per 5 parts by mass of the lipid components, preferably 1 part by mass of the active compound per 5 parts by mass of the lipid components as well as a vitamin or a derivative thereof, a method of producing it as well as composition containing the said formulation.

公开(公告)号：EP3158340B1

公开(公告)日：2017-12-13

申请号：EP15750109.9

申请日：2015-06-12

申请人： Wroclawskie Centrum Badan EIT + Sp. z o.o.

发明人： MARCINKOWSKA, Ewa ,  MARCHWICKA, Aleksandra ,  RADOM, Filip ,  MATUSIEWICZ, Marta ,  JAKIMOWICZ, Piotr ,  JELEN, Filip ,  MAZUREK, Maciej

IPC分类号： C07K16/28 ,  G01N33/574

CPC分类号： G01N33/57426 ,  G01N33/56972 ,  G01N33/57492 ,  G01N2800/52

公开(公告)号：EP3242865A1

公开(公告)日：2017-11-15

申请号：EP15830900.5

申请日：2015-12-10

申请人： Wroclawskie Centrum Badan Eit+ SP. Z O.O.

发明人： SOBOTA, Piotr ,  PETRUS, Rafal ,  BYKOWSKI, Dominik, Jerzy

IPC分类号： C07C67/03

CPC分类号： C07C67/03 ,  C08J11/24 ,  C08J2367/04 ,  C07C69/68

摘要： The object of the invention is a method of preparing esters of lactic and lactylatic acid in alcoholysis reaction of aliphatic polyester. In particular, the invention relates to a method of preparing ethyl lactate with simultaneous preparation of lactyllactate. Developed technology will be used in synthesis process of ethyl lactate and other esters of lactic acid that have versatile application in many industrial sectors.

公开(公告)号：EP3207125A1

公开(公告)日：2017-08-23

申请号：EP15798556.5

申请日：2015-10-13

申请人： Wroclawskie Centrum Badan EIT + SP Z O.O.

发明人： MARYCZ, Krzysztof ,  SMIESZEK, Agnieszka

IPC分类号： C12N5/074 ,  A61K31/155 ,  C12N5/0789

CPC分类号： C12N5/0607 ,  A61K31/155 ,  C12N5/0647 ,  C12N2501/105 ,  C12N2501/999

摘要： The object of the present invention is a preparation for pluripotent very small embryonic/epiblast-like stem cells (VSELs) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood, characterised in that it contains metformin, and the usage of metformin for pluripotent very small embryonic/epiblast-like stem cells (VSEL) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood and for use in treatment or prevention of conditions associated with reduced regenerative potential or premature senescence of cells.

摘要翻译： 本发明的目的是从骨髓到外周血的多能非常小的胚胎/上胚层样干细胞（VSEL）和造血干/祖细胞（HSPC）CD34 +动员的制备，其特征在于它含有二甲双胍， 使用二甲双胍从骨髓到外周血的多能非常小的胚胎/上胚层样干细胞（VSEL）和造血干/祖细胞（HSPC）CD34 +动员，并用于治疗或预防与降低的再生潜能或早产相关的病症 细胞衰老。

公开(公告)号：EP3058094B1

公开(公告)日：2018-01-17

申请号：EP14810038.1

申请日：2014-10-15

申请人： Wroclawskie Centrum Badan EIT + Sp. z o.o.

发明人： PULA, Bartosz ,  OLBROMSKI, Mateusz ,  AMBICKA, Aleksandra ,  GOMULKIEWICZ, Agnieszka ,  RYS, Janusz ,  PODHORSKA-OKOLÓW, Marzena ,  SIEW, Hwa, Ong ,  DZIEGIEL, Piotr

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The invention relates to a method for detection of decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines in breast cancer patients, according to which the evaluation of PIP gene expression is performed with the use of real-time PCR method on the isolated total RNA in the sample of tissue material taken from patient from primary tumour of ductal breast cancer, wherein the statistically significant lower expression of PIP mRNA indicates decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines. The invention provides a prediction test, which enables rapid classification of patients in terms of their responsiveness for adjuvant chemotherapy and thus the undertaking of appropriate therapeutic intervention.

公开(公告)号：EP3041510A1

公开(公告)日：2016-07-13

申请号：EP14762112.2

申请日：2014-07-25

申请人： Wroclawskie Centrum Badan EIT + SP Z O.O.

发明人： FRACKOWIAK, Renata ,  POSADOWSKA, Urszula ,  WILK, Kazimiera ,  GAMIAN, Andrzej

IPC分类号： A61K47/34 ,  A61K41/00 ,  A61K9/107

摘要： The subject of the present invention are nanocarriers of the polymer micelle type based on block copolymers, made using thin film hydration and meant for use in w pharmaceutical formulations as active ingredient carriers, i.e. for photosensitizers used in the photodynamic therapy of tumours, a method of making them and their use.

公开(公告)号：EP3003362A1

公开(公告)日：2016-04-13

申请号：EP14738894.6

申请日：2014-06-04

申请人： Wroclawskie Centrum Badan EIT + Sp. z o.o.

发明人： GOZDZIEWICZ, Tomasz ,  LUKASIEWICZ, Jolanta ,  LUGOWSKI, Czeslaw

IPC分类号： A61K39/02 ,  C08B37/00

CPC分类号： A61K47/4823 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/0275 ,  A61K39/0283 ,  A61K39/39 ,  A61K47/61 ,  A61K2039/55572 ,  A61K2039/6037 ,  C07K16/1228 ,  C07K16/1232 ,  C07K16/1235 ,  C07K2317/76 ,  C08B37/00 ,  Y02A50/476

摘要： The subject of the present invention is an isolated antigen being an immunogenic form of the common enterobacterial antigen (ECA) of Gram-negative bacteria of the family Enterobacteriaceae: ECA combined with lipopolysaccharide (ECALPS); a glycoconjugate of inactivated form of this antigen with a protein, as well as compositions and vaccines containing such an antigen/glycoconjugate designed for the prevention and treatment infections caused by Gram-negative bacteria.

公开(公告)号：EP2705048A1

公开(公告)日：2014-03-12

申请号：EP12730029.1

申请日：2012-05-06

申请人： Wroclawskie Centrum Badan EIT + Sp. z o.o.

发明人： PIETKIEWICZ, Jadwiga ,  SZYDELKO, Agnieszka ,  DZIERZBA, Katarzyna ,  DANIELEWICZ, Regina ,  STANISZEWSKA, Magdalena ,  BARTYS, Arkadiusz ,  GAMIAN, Andrzej

IPC分类号： C07K1/14 ,  C07K14/765

CPC分类号： C07K14/765 ,  G01N21/49 ,  Y10T428/2982

摘要： The subject of the present invention is a pure monomeric bovine serum albumin, a method of producing it characterised by the use column chromatography in resin and a method of identifying it using dynamic light scattering.

摘要翻译： 本发明的主题是纯单体牛血清白蛋白，其特征在于使用树脂中的柱色谱法和使用动态光散射来鉴定其的方法。

公开(公告)号：EP3017004A2

公开(公告)日：2016-05-11

申请号：EP14752956.4

申请日：2014-06-30

申请人： Wroclawskie Centrum Badan Eit+ SP. Z O.O.

发明人： MERGO, Pawel ,  GIL, Malgorzata ,  PEDZISZ, Janusz ,  SKORUPSKI, Krzysztof ,  CZYZEWSKA, Lidia

IPC分类号： C08L33/10 ,  C08F120/14 ,  G02B1/04 ,  C08J5/18

CPC分类号： G02B1/045 ,  C08F120/14 ,  C08F220/14 ,  C08L33/12

摘要： The present invention relates to a polymer composition for the production of microstructured optical fibres comprised of methyl methacrylate as a monomer, benzoyl peroxide as a polymerization initiator and thioglycolic acid as a chain transfer agent. The present invention also provides a method for producing microstructured fibres based on a polymer composition and for using the polymer composition for the production of microstructured optical fibres.

摘要翻译： 本发明涉及用于生产由甲基丙烯酸甲酯作为单体，过氧化苯甲酰作为聚合引发剂和巯基乙酸作为链转移剂的微结构光纤的聚合物组合物。 本发明还提供了一种基于聚合物组合物生产微结构纤维的方法以及用于生产微结构光纤的聚合物组合物。

公开(公告)号：EP2834034A1

公开(公告)日：2015-02-11

申请号：EP13724023.0

申请日：2013-03-22

申请人： Wroclawskie Centrum Badan EIT + SP Z O.O.

发明人： ANTONCZAK, Arkadiusz ,  KOCON, Dariusz ,  NOWAK, Maciej ,  KOZIOL, Pawel ,  KACZMAREK, Pawel ,  WAZ, Adam ,  ABRAMSKI, Krzysztof

IPC分类号： B23K26/00 ,  B23K26/04 ,  B23K26/08 ,  B41M5/24 ,  B44C1/22

CPC分类号： B23K26/0066 ,  B23K26/0006 ,  B23K26/046 ,  B23K26/082 ,  B23K2203/50 ,  B41M5/24 ,  B41M5/262 ,  B44C1/228

摘要： The present invention relates to a system for color marking of the metals by means of laser comprising the laser (L) generating a laser beam (W), which is directed by an electronically controlled element correcting the divergence of the beam (V) followed by galvo mirrors of the scanner or the plotter (X) and (Y) changing the angle of the beam or shifting the beam in the plotter system and then through the optics (F) on the marked surface (S) at a distance (D) from the optics (F) characterized in that it comprises a control unit (U) to read a signal proportional to the power (2) read by means of the head of the power meter (P), into which a part of the laser beam is preferably directed from an uncoupling mirror (M), which is arranged in the path of the laser beam between the galvo mirrors of the scanner (X) (Y) and the surface (S), preferably in front of or behind the optics (F), and to read a signal proportional to the distance (1) of the distance sensor (DS), and to send the signals controlling a deflection of the beam (3) and (4) and its divergence (5) in the galvo mirrors of the scanner (Y) and (X), and to send the power control signal (6) of the laser (L), wherein the unit is controlled by a control device, preferably a computer (C), and a method for color marking of the metals using this system.