公开(公告)号：EP2527360B1

公开(公告)日：2015-10-28

申请号：EP12162903.4

申请日：2008-06-04

申请人： Synergy Pharmaceuticals Inc.

发明人： Shailubhai, Kunwar ,  Jacob, Gary S.

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61K47/48 ,  A61P1/00

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

公开(公告)号：EP2561363A2

公开(公告)日：2013-02-27

申请号：EP11748712.4

申请日：2011-04-20

申请人： Memed Diagnostics, Ltd.

发明人： OVED, Kfir ,  EDEN, Eran

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  A61K45/06 ,  G01N33/569 ,  G01N33/56911 ,  G01N2333/4737 ,  G01N2333/914

摘要： The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one of more polypeptide determinant in which the alteration of the expression level indicates infection of the patient in a sample of the subject and determining a clinically significant alteration in the level of the one or more polypeptides in the sample, wherein the alteration indicates an infection in the subject. The methods provided herein are for distinguishing between bacterial infection, mixed infection and/or viral infection.

摘要翻译： 本发明提供了使用生物标记物检测感染的方法。

公开(公告)号：EP1971288B1

公开(公告)日：2013-02-13

申请号：EP06849026.7

申请日：2006-12-18

申请人： Neurotech USA, Inc.

发明人： KAUPER, Konrad ,  TAO, Weng ,  STABILA, Paul

IPC分类号： A61K38/18 ,  A61K35/44 ,  A61K9/00 ,  A61P27/02

CPC分类号： A61K38/57 ,  A61K9/0048 ,  A61K9/0051 ,  A61K38/185 ,  A61K38/2066 ,  A61K2035/128 ,  Y02A50/401 ,  A61K2300/00

摘要： The invention provides micronized encapsulated cell therapy devices that are capable of delivering a biologically active molecule to the eye. Also provided are methods of using the same to deliver biologically active molecules to the eye and to treat ophthalmic disorders in patients suffering there from.

公开(公告)号：EP2542230A2

公开(公告)日：2013-01-09

申请号：EP11751519.7

申请日：2011-03-07

申请人： President and Fellows of Harvard College ,  Brown University

发明人： MOONEY, David, J. ,  BORSELLI, Cristina ,  VANDENBURGH, Herman ,  SILVA, Eduardo ,  WANG, Lin ,  SHVARTSMAN, Dmitry ,  STORRIE, Hannah ,  LICHTMAN, Jeff

IPC分类号： A61K9/70 ,  A61K9/06 ,  A61K47/48 ,  A61K38/18 ,  A61P17/02 ,  A61P17/00

CPC分类号： A61K38/30 ,  A61K9/06 ,  A61K9/19 ,  A61K35/12 ,  A61K35/34 ,  A61K38/18 ,  A61K38/1866 ,  A61L27/20 ,  A61L27/3612 ,  A61L27/3826 ,  A61L27/3873 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2400/16 ,  A61L2430/32 ,  C08L2201/12 ,  A61K2300/00

摘要： An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.

摘要翻译： 改进的装置和方法用于肌肉组织的延伸修复和再生。 示例性装置包括（a）包含ECM组分的支架; （b）生长因子如VEGF和IGF的组合; 和（c）肌原细胞群体。 该装置的植入导致肌肉再生和长时间的修复。

公开(公告)号：EP2513144A1

公开(公告)日：2012-10-24

申请号：EP10798428.8

申请日：2010-12-16

申请人： Bosch, Philip

发明人： Bosch, Philip

IPC分类号： C07K16/24 ,  A61K39/395 ,  A61P13/10

CPC分类号： C07K16/241 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

摘要： The present invention relates to the use of adalimumab (Humira™), for the treatment of a pain and/or a lower urinary tract symptom(s) (LUTS) associated with interstitial cystitis and/or painful bladder syndrome and/or bladder pain syndrome.

公开(公告)号：EP2510351A1

公开(公告)日：2012-10-17

申请号：EP10836542.0

申请日：2010-12-07

申请人： Yale University

发明人： KOSER, Hur

IPC分类号： G01N33/49 ,  B03C1/32

CPC分类号： G01N15/1056 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/06 ,  B01L2300/0848 ,  B03C1/023 ,  B03C1/23 ,  B03C1/253 ,  B03C1/288 ,  B03C1/32 ,  B03C2201/18 ,  B03C2201/24 ,  B03C2201/26 ,  C12M47/04 ,  C12N13/00 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1081

摘要： A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.

摘要翻译： 描述了用于分离悬浮在生物相容性铁磁流体中的细胞样品的装置。 该装置包括具有样品入口，至少一个出口和在相同入口和至少一个出口之间的长度的微流体通道，其中样品可以被添加到样品入口并沿着微流体通道长度至少至少 一个出口。 该装置包括多个电极和用于向多个电极施加电流以产生沿着微流体通道长度的磁场图案的电源。 本发明还包括使用所述装置分离至少一种细胞类型的方法。

公开(公告)号：EP2159285B1

公开(公告)日：2012-09-26

申请号：EP09166658.6

申请日：2004-01-28

申请人： 454 Life Sciences Corporation

发明人： Leamon, John H. ,  Lohman, Kenton ,  Rothberg, Jonathan M. ,  Weiner, Michael P.

IPC分类号： C12N15/10 ,  C12Q1/68

CPC分类号： C12Q1/686 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0877 ,  C07H21/00 ,  C12N15/1075 ,  C12N15/1093 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6844 ,  C12Q1/6865 ,  C12Q1/6867 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6484 ,  G01R33/1269 ,  Y02P20/582 ,  Y10T436/143333 ,  C12Q2565/119 ,  C12Q2531/113 ,  C12Q2565/537 ,  C12Q2547/107 ,  C12Q2547/101 ,  C12Q2537/143 ,  C12Q2527/125 ,  C12Q2525/186 ,  C12Q2565/301 ,  C12Q2563/149 ,  C12Q2531/125 ,  C12Q2537/149 ,  C12Q2535/119

公开(公告)号：EP2449111A2

公开(公告)日：2012-05-09

申请号：EP10793701.3

申请日：2010-06-30

申请人： Performance Plants, Inc.

发明人： WAN, Jiangxin ,  HUANG, Yafan

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01H5/10 ,  C12N15/00 ,  C12N15/29 ,  C07K14/415

CPC分类号： C12N15/8273

摘要： The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means to increase expression level of a bHLH subgroup Ib gene expression or activity, wherein a desired phenotype such as increased heat tolerance relative to a wild type control plant following heat stress results in reduced flower abortion and increased yield. Included are plants produced by said methods. The invention also relates to nucleic acid sequences and constructs useful such methods and methods of generating and isolating plants having increased expression of a bHLH subgroup Ib expression or activity.

公开(公告)号：EP2414344A1

公开(公告)日：2012-02-08

申请号：EP10711971.1

申请日：2010-03-31

申请人： ArQule, Inc.

发明人： NAMDEV, Nivedita ,  TANDON, Manish ,  WANG, Jianqiang ,  DALTON, Audra ,  VENSEL, David ,  PALMA, Rocio ,  ASHWELL, Mark, A. ,  WESTLUND, Neil

IPC分类号： C07D401/04 ,  A61K31/435 ,  A61P35/00

CPC分类号： C07D401/04

摘要： The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的吲哚并吡啶酮化合物和合成这些化合物的方法。 本发明还涉及含有取代的吲哚并吡啶酮化合物的药物组合物以及通过将这些化合物或药物组合物给予有需要的个体来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：EP2408302A1

公开(公告)日：2012-01-25

申请号：EP10753836.5

申请日：2010-02-05

申请人： Aciex Therapeutics, Inc.

发明人： CHAPIN, Matthew, Jonathan ,  ABELSON, Mark, Barry ,  MINNO, George ,  NICE, Jackie ,  GOMES, Paul

IPC分类号： A01N43/40 ,  A61K31/445

CPC分类号： A61K31/4535 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/568

摘要： The present invention provides topical formulations of ketotifen that provide a comfortable formulation when instilled in the eye and are effective in the treatment and prevention of ocular allergy, particularly allergic conjunctivitis. The invention further provides methods of treating and preventing ocular allergy by in a subject in need of such treatment by topical application of the ketotifen formulations of the invention to the eye of a subject in need thereof.