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公开(公告)号：EP2673358A4
公开(公告)日：2014-12-03
申请号：EP12744365
申请日：2012-02-07
发明人： YU JUNYING , VODYANYK MAKSYM A
CPC分类号： C12N5/0647 , A61K35/28 , C12N2501/60 , C12N2501/999 , C12N2506/02 , C12N2506/45 , C12N2510/00
摘要： The invention generally regards methods for providing hematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
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2.发明公开A COMPENDIUM OF READY-BUILT STEM CELL MODELS FOR INTERROGATION OF BIOLOGICAL RESPONSE 有权KOMPENDIUM AUS FERTIG GEBAUTEN STAMMZELLMODELLEN ZUR ABFRAGE BIOLOGISCHER REAKENEN
公开(公告)号：EP2582793A4
公开(公告)日：2014-05-14
申请号：EP11796365
申请日：2011-06-15
CPC分类号： G01N33/5023 , G01N33/5014 , G01N33/5041 , G01N33/5073
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公开(公告)号：EP2558569A4
公开(公告)日：2014-03-05
申请号：EP11769522
申请日：2011-04-13
IPC分类号： C12N5/0735 , C12N5/071
CPC分类号： C12N15/85 , A61K35/407 , C12N5/067 , C12N2501/12 , C12N2501/237 , C12N2501/60 , C12N2506/02 , C12N2506/45 , G01N33/5067
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公开(公告)号：EP2591093A4
公开(公告)日：2014-01-08
申请号：EP11804353
申请日：2011-07-07
发明人： YU JUNYING , VODYANYK MAKSYM A
CPC分类号： C12N15/85 , C12N5/069 , C12N5/0692 , C12N2501/40 , C12N2506/02 , C12N2506/45 , G01N33/5064 , G01N2500/10
摘要： The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
摘要翻译： 本发明通常涉及从多种细胞来源例如多能干细胞提供内皮细胞和内皮细胞前体的方法。 还提供包括所提供的内皮细胞的治疗组合物和使用它们用于治疗受试者的方法。
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公开(公告)号：EP2694644A4
公开(公告)日：2014-12-17
申请号：EP12764571
申请日：2012-03-30
发明人： MEYER NATHAN , STANKEWICZ CASEY , RAJESH DEEPIKA , GEORGE MATTHEW
CPC分类号： C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
摘要翻译： 提供了多能干细胞分化的方法和组成。 例如，在某些方面，包括在基本上不含生长因子如FGF和TGFβ的培养基中用于神经分化的引发干细胞的方法。 作为优点，神经细胞可以具有改善的一致性和纯度。
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公开(公告)号：EP2601289A4
公开(公告)日：2014-01-22
申请号：EP11815273
申请日：2011-08-03
IPC分类号： C12N5/074 , C12N5/0781 , C12N5/10 , C12N15/33
CPC分类号： C12N5/0696 , C12N15/63 , C12N15/85 , C12N2501/06 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2510/00 , C12N2510/04 , C12N2710/16243 , C12N2800/108
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公开(公告)号：EP2490701A4
公开(公告)日：2013-09-25
申请号：EP10828771
申请日：2010-10-19
IPC分类号： A61K35/12 , A61K38/18 , A61P9/00 , A61P9/04 , C12N5/0735
CPC分类号： C12N5/0657 , A61K48/00 , C07H21/04 , C07K14/475 , C07K14/50 , C12N5/0606 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/48 , C12N2501/70 , C12N2501/727 , C12N2506/02 , C12N2506/45 , C12N2509/00 , C12N2510/00
摘要： Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.
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公开(公告)号：EP2496689A4
公开(公告)日：2013-06-12
申请号：EP10829086
申请日：2010-11-04
发明人： YU JUNYING
CPC分类号： C12N5/0696 , A61K35/545 , C12N2501/10 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/60 , C12N2501/70 , C12N2510/00 , C12N2533/52
摘要： Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.
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公开(公告)号：EP2582792A4
公开(公告)日：2013-12-18
申请号：EP11796584
申请日：2011-06-20
发明人： MEYER NATHAN , SWANSON BRAD , FIENE STEVE
CPC分类号： C12N5/0657 , C12N2500/00 , C12N2501/999
摘要： Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.
摘要翻译： 提供了维持心肌细胞的方法和组成。 例如，在某些方面，包括在基本上不含血清或含有透析血清的培养基中培养心肌细胞以保持长期纯度的方法。 在另外的方面，可以提供用于调节心肌细胞的方法。
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10.发明公开GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD 有权从小周外周血中诱导多潜能干细胞的制备
公开(公告)号：EP2582794A4
公开(公告)日：2013-12-11
申请号：EP11796290
申请日：2011-06-14
发明人： MACK AMANDA
IPC分类号： C12N5/0789 , C07K14/475 , C12N5/02 , C12N5/074
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/98 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/15 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2501/998 , C12N2506/11 , C12N2510/00
摘要： Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
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