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    DISPENSING PREPARATION DEVICE, DISPENSING DEVICE, AND DISPENSING PREPARATION METHOD
    1.
    发明公开
    DISPENSING PREPARATION DEVICE, DISPENSING DEVICE, AND DISPENSING PREPARATION METHOD 审中-公开

    公开(公告)号：EP4556551A1

    公开(公告)日：2025-05-21

    申请号：EP23839593.3

    申请日：2023-07-10

    Applicant: Cyfuse Biomedical K. K.

    Inventor： KISHII, Yasuto ,  TOKUNAGA, Norihiko

    IPC: C12M1/02 ,  C12M1/26

    Abstract: A dispensing preparation apparatus capable of stirring cell suspension so as not to damage cells is desired. It is solved by the dispensing preparation apparatus including a reservoir configured to accommodate cell suspension, the reservoir having an opening, a discharge tip portion of a pipette repeatedly entering and exiting through the opening, the pipette discharging the cell suspension to a cell accommodating portion, a tank configured to accommodate the cell suspension, a pipe connecting the tank and the reservoir, the pipe configured to allow the cell suspension to flow inside from the tank to the reservoir by a pump unit, a turntable configured to rotate the tank about a rotation axis perpendicular to a bottom surface of the tank, and a controller configured to control rotation of the turntable, the pipe arranged such that an opening at one end of the pipe contacts an inner wall of the reservoir and an opening at another end of the pipe is spaced apart from an inner wall of the tank.

    QUALITY EVALUATION METHOD FOR SPHEROID INCLUDING HEPATOCYTES
    2.
    发明公开
    QUALITY EVALUATION METHOD FOR SPHEROID INCLUDING HEPATOCYTES 审中-公开

    公开(公告)号：EP4428812A1

    公开(公告)日：2024-09-11

    申请号：EP24158147.9

    申请日：2024-02-16

    Applicant: SCREEN Holdings Co., Ltd. ,  Cyfuse Biomedical K. K.

    Inventor： HASEBE, Ryo ,  MAEKAWA, Toshihiko ,  INOUE, Ayu

    IPC: G06T7/00

    CPC classification number: G06T7/0012 ,  G06T2207/1010120130101 ,  G06T2207/2008120130101 ,  G06T2207/3002420130101 ,  G06T2207/3005620130101

    Abstract: According to this evaluation method, first, spheroids obtained by three-dimensional culture of multiple kinds of liver-derived cells are imaged by optical coherence photography (image acquisition step), a localization region is extracted from the photographic image (region extraction step), the localization region is analyzed (analysis step), and the condition of the spheroid is evaluated (evaluation step). The analysis step includes a first calculation step (S41) of calculating the area of the entire spheroid in the photographic image, a second calculation step (S42) of calculating the area of the localization region, a third calculation step (S43) of calculating the ratio of the localization region on the basis of the two areas, and a fourth calculation step (S44) of calculating an evaluation parameter on the basis of the ratio. With the use of this evaluation parameter, there is provided an evaluation method that makes it possible to noninvasively observe a localization region of a spheroid used in a bio 3D printer and evaluate the condition of the spheroid without processing cells by staining or the like.

    CELL TRAY AND DEVICE, METHOD AND SYSTEM FOR PRODUCING CELL STRUCTURE
    4.
    发明公开
    CELL TRAY AND DEVICE, METHOD AND SYSTEM FOR PRODUCING CELL STRUCTURE 有权
    电池汽车设备，方法和系统用于单元结构生产

    公开(公告)号：EP3091067A1

    公开(公告)日：2016-11-09

    申请号：EP15845301.9

    申请日：2015-09-25

    Applicant: Cyfuse Biomedical K. K.

    Inventor： KUCHIISHI Koji ,  TAMURA Tadashi

    IPC: C12M1/00 ,  C12N5/07 ,  C12N11/02

    CPC classification number: C12N5/0062 ,  C12M21/08 ,  C12M23/12 ,  C12M25/00 ,  C12M33/04 ,  C12M33/06 ,  C12M41/46 ,  C12N5/00 ,  C12N11/00

    Abstract: Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole. Also provided is a system for producing a cell structure, said system comprising: a determination part that examines the characteristics of cell aggregates; a fractionation part that classifies the cell aggregates depending on the results of the examination by the determination part; a discharge part that disposes the cell aggregates in a cell tray depending on the results of the classification by the fractionation part; a puncture part that pass through a plurality of cell aggregates disposed in the cell tray; and a holding part that aligns and holds a plurality of puncture parts passing through a plurality of cell aggregates.

    CELL STRUCTURE PRODUCTION DEVICE
    10.
    发明公开
    CELL STRUCTURE PRODUCTION DEVICE 审中-公开

    公开(公告)号：EP3514225A1

    公开(公告)日：2019-07-24

    申请号：EP17911399.8

    申请日：2017-10-30

    Applicant: Cyfuse Biomedical K. K.

    Inventor： KISHII Yasuto ,  TOKUNAGA Norihiko

    IPC: C12M3/00

    Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.

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