公开(公告)号：EP1185948B1

公开(公告)日：2006-03-01

申请号：EP99948226.8

申请日：1999-09-14

申请人： Lion bioscience AG

发明人： GRASS, George M. ,  LEESMAN, Glen, D. ,  NORRIS, Daniel, A. ,  SINKO, Patrick, J. ,  WEHRLI, John, E.

IPC分类号： G06F19/00 ,  C12Q1/00

CPC分类号： C40B30/02 ,  C40B50/02 ,  Y02A90/26

摘要： The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data. The PK tool of the invention may be provided as a computer system, as an article of manufacture in the form of a computer-readable medium, or a computer program product and the like. Subsystems and individual components of the PK tool also can be utilized and adapted in a variety of disparate applications for predicting the fate of an administered compound. The PK tool and methods of the invention can be used to screen and design compound libraries, select and design drugs, as well as predict drug efficacy in mammals from in vitro and/or in vivo data of one or more compounds of interest. The PK tool and methods of the invention also finds use in selecting, designing, and preparing drug compounds, and multi-compound drugs and drug formulations (i.e., drug delivery system) for preparation of medicaments for use in treating mammalian disorders.

公开(公告)号：EP1364312A2

公开(公告)日：2003-11-26

申请号：EP01974337.6

申请日：2001-10-16

申请人： LION bioscience AG

发明人： CROFT, David ,  RICHTER, Stefan

IPC分类号： G06F17/30

CPC分类号： G06F17/3089

摘要： A method and apparatus is provided for creating links between otherwise unlinked databases. The process for creating these links may be initiated by selecting text in a source database where it would be desirable to have a link originate. Thereafter, searching at least one target database for information related to the selected text. Associating address information for each related information block with the selected text in the source database to create a link.

公开(公告)号：EP1358611A2

公开(公告)日：2003-11-05

申请号：EP01956015.0

申请日：2001-07-30

申请人： LION bioscience AG

发明人： GRASS, George, M. ,  LEESMAN, Glen, D. ,  NORRIS, Daniel ,  SINKO, Patrick ,  ATHWAL, Jehangir ,  SAGE, Carleton ,  BREMER, Troy ,  HOLME, Kevin

IPC分类号： G06F19/00

CPC分类号： G06F19/704 ,  G06F19/3418 ,  G06F19/707 ,  G16H50/50

摘要： A method for developing a predictive model of a chemical compound property. The method includes obtaining at least one descriptor from structural data for each of a plurality of compounds. At least one chemical compound property is obtained for each of the plurality of compounds. The predictive model is developed by mapping the at least one descriptor to the chemical compound property. The chemical compound property may be an ADME property. The ADME property may be absorption. The chemical compound property may also be a toxicity property.

公开(公告)号：EP1317542A2

公开(公告)日：2003-06-11

申请号：EP01982261.8

申请日：2001-09-07

申请人： LION Bioscience AG

发明人： CASARI, Georg ,  HÖFER, Michael ,  JACKSON, David ,  KRANZ, Harald ,  OTTE, Kerstin ,  REMMEL, Bettina ,  SUCKOW, Jörg

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  G01N33/68 ,  C07K16/28 ,  C12Q1/68 ,  C12N15/11 ,  A61K48/00 ,  A61K39/395 ,  A61K31/7088

CPC分类号： C07K14/70567 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to a novel nuclear receptor called 'L66' or also FXR-β a homologue of the FXR-α, a prototypical type 2 nuclear receptor. The invention also relates to the isolated nucleic acid sequence of L66 and the isolated protein thereof. The invention further relates to processes for isolating and/or producing the nucleic acid or the protein as well as methods of use of the receptor L66.

摘要翻译： 本发明涉及称为'L66'的新型核受体或FXR-α（原型2型核受体）的同系物FXR-β。 本发明还涉及L66的分离的核酸序列及其分离的蛋白质。 本发明还涉及用于分离和/或生产核酸或蛋白质的方法以及受体L66的使用方法。

公开(公告)号：EP1218739A4

公开(公告)日：2003-06-04

申请号：EP00952407

申请日：2000-08-02

申请人： LION BIOSCIENCE AG

发明人： FOROOD BEHROUZ ,  FLATT BRENTON T ,  CHASSAING CHRISTOPHE ,  KATRITZKY ALAN K

IPC分类号： C07D213/74 ,  C07D213/75

CPC分类号： C07D213/74

公开(公告)号：EP1218384A4

公开(公告)日：2002-11-20

申请号：EP00952360

申请日：2000-08-01

申请人： LION BIOSCIENCE AG

发明人： LANG HENGYUAN ,  PEI YAZHONG

IPC分类号： C07D487/04 ,  C07D487/14

CPC分类号： C07D487/04

公开(公告)号：EP1236798A2

公开(公告)日：2002-09-04

申请号：EP01112165.4

申请日：2001-05-17

申请人： LION Bioscience AG

发明人： Höfer, Michael, Dr. ,  Hofmann, Martin, Dr. ,  Kaiser, Carmen, Dr. ,  Kranz, Harald, Dr. ,  Löbbert, Ralf, Dr. ,  Schlüter, Thomas, Dr.

IPC分类号： C12N15/10 ,  C07K14/47 ,  C12N5/10

CPC分类号： C12N15/1093 ,  C07K14/47 ,  C12N15/1096 ,  C12N15/66

摘要： Beschrieben wird ein Verfahren zur Herstellung einer Genbibliothek, vorzugsweise einer cDNA-Genbibliothek, und eine durch dieses Verfahren erhältliche Genbibliothek.

摘要翻译： 基因文库（A）包含编码参与氨基酸合成，细胞/能量代谢，脂肪酸/磷脂代谢，嘌呤/嘧啶/核苷/核苷酸的合成或分解的DNA基因序列（或其部分），DNA复制/ 转录/翻译，或是转运/结合蛋白。 包含（A）的转化体也包括独立权利要求。

公开(公告)号：EP1221671A2

公开(公告)日：2002-07-10

申请号：EP01104070.6

申请日：2001-02-20

申请人： LION Bioscience AG

发明人： O'Donoghne, Séan ,  Fries, Karsten

IPC分类号： G06F19/00

CPC分类号： G06F19/26 ,  G06F19/28

摘要： The present invention for the first time provides for a method for organizing and depicting one or more biological elements stemming from one or more databases and one or more data sets whereby at least a first feature element is determined from each of said data sets, a graphical representation is made for displaying the biological elements corresponding to said data sets and a display of a basic environment element is enhanced by locating at least one of said graphical representations of said biological elements on the display depending on the information contained in the feature element.

摘要翻译： 本发明首次提供了一种用于组织和描绘源自一个或多个数据库和一个或多个数据集的一个或多个生物元件的方法，由此至少第一特征元素从每个所述数据集确定，图形 用于显示对应于所述数据集的生物元素的表示，并且通过根据包含在特征元素中的信息将所述生物元素的所述图形表示中的至少一个定位在显示器上来增强基本环境元素的显示。

公开(公告)号：EP1198571A2

公开(公告)日：2002-04-24

申请号：EP00958230.5

申请日：2000-08-07

申请人： LION Bioscience AG

发明人： KILGER, Christian ,  MOTZ, Michael ,  LÖSER, Eva ,  KÖGL, Manfred

IPC分类号： C12N15/31 ,  C12N15/54 ,  C12N15/10 ,  C12N15/62 ,  C12N15/81 ,  C12N9/12 ,  C12N1/19 ,  C07K14/195 ,  C07K16/18 ,  C07K16/40 ,  C12P19/34 ,  C12Q1/68

CPC分类号： C12N9/1252 ,  C07K14/195 ,  C07K2319/00

摘要： The invention relates to a recombinant chimeric protein comprising a) a first domain with a nucleic acid synthesis activity and b) an interaction mediating sequence, whereby said interaction mediating sequence can form a complex through the nucleic acid synthesis activity and a slide bracketing protein. Said complex is different from the complex formed through the nucleic acid synthesis activity and/or the slide tying protein with their natural interaction partner(s).

公开(公告)号：EP1221671A3

公开(公告)日：2006-03-29

申请号：EP01104070.6

申请日：2001-02-20

申请人： LION bioscience AG

发明人： O'Donoghue, Séan ,  Fries, Karsten

IPC分类号： G06F19/00

CPC分类号： G06F19/26 ,  G06F19/28

摘要： The present invention for the first time provides for a method for organizing and depicting one or more biological elements stemming from one or more databases and one or more data sets whereby at least a first feature element is determined from each of said data sets, a graphical representation is made for displaying the biological elements corresponding to said data sets and a display of a basic environment element is enhanced by locating at least one of said graphical representations of said biological elements on the display depending on the information contained in the feature element.