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公开(公告)号：EP1545625A2
公开(公告)日：2005-06-29
申请号：EP03736977.4
申请日：2003-06-06
发明人： MCCORMICK, Alison A., , SMITH, Mark L., , PALMER, Kenneth E., , LINDBO, John A., , NGUYEN, Long V., , POGUE, Gregory P.,
IPC分类号： A61K48/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/55516 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/4748 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2760/16122 , C12N2760/18022 , C12N2770/00022 , C12N2770/00023
摘要： Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
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公开(公告)号：EP1539360A1
公开(公告)日：2005-06-15
申请号：EP03734445.4
申请日：2003-06-05
CPC分类号： B04B1/02 , B04B5/0407 , B04B11/06 , B04B15/06 , B04B15/08
摘要： A centrifuge (10) is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge (10) includes a rotatable centrifuge bowl (12) having a radially outer wall (16) inclined outwardly so that during centrifugation liquid in the bowl (12) climbs the outer wall (16). The centrifuge bowl (12) is contained in a vacuum sealed housing (14) so that a material of interest contained in the bowl (12) including said liquid can be subjected to a vacuum. A system for automated cleaning of the centrifuge (10) is also provided.
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公开(公告)号：EP1096021A3
公开(公告)日：2004-03-10
申请号：EP01102344.7
申请日：1998-02-04
IPC分类号： C12P17/00
CPC分类号： A61K31/787 , A61K31/00 , C12P17/00
摘要： Enzymatically tyrosinose produced melanins are described that are useful in the treatment of HIV infection. The melanins are optionally modified to contain chemical moieties such as halogens, sulfates, or sulfonyl groups. Additionally, the enzymatically synthesized melanins may be modified, or further modified, by chemical oxidation.
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4.发明公开TRAINABLE ADAPTIVE FOCUSED REPLICATOR NETWORK FOR ANALYZING DATA 有权训练的，适应性强的重点REPLIKATORNETZWERK数据分析
公开(公告)号：EP1212727A2
公开(公告)日：2002-06-12
申请号：EP00952231.9
申请日：2000-07-25
发明人： MALYJ, Wasyl
IPC分类号： G06N1/00
CPC分类号： G06K9/6232 , G06F19/22 , G06T9/008 , Y10S707/99933
摘要： Electronic data is classified using adaptive focused replicator network (AFRNs). AFRNs are sets of array elements, each array element being trainable in order to replicate a predetermined sub-group of data. Unknown data is inputted into each and every array element in an AFRN array and then replicated by each element array. A comparison is made for each array element to determine the accuracy of each replication. If only one array element successfully replicates the unknown data, then the unknown data is classified in accordance with the corresponding predetermined sub-group of data.
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5.发明公开METHOD OF CORRELATING SEQUENCE FUNCTION BY TRANSFECTING A NUCLEIC ACID SEQUENCE OF A DONOR ORGANISM INTO A PLANT HOST IN AN ANTI-SENSE OR POSITIVE SENSE ORIENTATION 审中-公开方法用于测试序列的功能通过转染核序列从供体生物体的植物，HOST感测或积极意义取向
公开(公告)号：EP1196557A1
公开(公告)日：2002-04-17
申请号：EP00953673.1
申请日：2000-07-21
CPC分类号： C12N15/1079 , C07K14/415 , C12N15/8203 , C12N15/8242 , C12N15/8243 , C12N15/825 , C12N15/8257 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to a method for correlating the function of a host organism derived nucleic acid sequence by a transient expression of the nucleic acid sequence in an antisense or positive sense orientation in a plant host.
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6.发明公开METHOD FOR CONFERRING HERBICIDE, PEST, OR DISEASE RESISTANCE IN PLANT HOSTS 审中-公开方法用于放置除草剂，抗虫或抗病ON菜农
公开(公告)号：EP1196556A2
公开(公告)日：2002-04-17
申请号：EP00948964.2
申请日：2000-07-21
CPC分类号： C12N15/8283 , A01H1/04 , A01H5/12 , C12N9/0004 , C12N9/1092 , C12N15/1034 , C12N15/1079 , C12N15/8274 , C12Q1/68
摘要： The present invention relates to a method for conferring herbicide, pest, and disease resistance in plant hosts. Specifically, the present invention employs transient viral expression vectors to express proteins or enzymes conferring resistance in plant hosts. In addition, expressing a library of nucleotide sequence variants in a sense or antisense orientation in a plant host may be used to determine the targets of a herbicide or pathogen and to determine new herbicides or pathogens.
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7.发明授权
公开(公告)号：EP1263779B1
公开(公告)日：2004-12-15
申请号：EP00973516.8
申请日：2000-10-13
发明人： REINL, Stephen, J. , TURPEN, Thomas, H. , McCormick, Alison A. , Tusé, Daniel , Lindbo, John A.
CPC分类号： C12N15/8258 , A61K2039/505 , C07K16/00 , C07K2317/13 , C07K2317/622
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公开(公告)号：EP1013771B1
公开(公告)日：2004-10-06
申请号：EP99124650.5
申请日：1989-02-24
发明人： Grill, Lawrence K. , Erwin, Robert L. , Berliner, David L. , Hubbard, Ernest T.,Jr. , Turpen, Thomas H.
CPC分类号： C12N15/8257 , C07K14/005 , C12N9/0071 , C12N9/1074 , C12N9/6459 , C12N15/8203 , C12N15/8258 , C12N15/86 , C12N2770/32622 , C12N2770/32722 , C12N2830/002 , C12N2830/55 , C12Y114/18001 , C12Y302/01031 , C12Y304/21069
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9.发明公开FLEXIBLE PROCESSING APPARATUS FOR ISOLATING AND PURIFYING VIRUSES, SOLUBLE PROTEINS AND PEPTIDES FROM PLANT SOURCES 审中-公开柔性加工设备进行隔离清理病毒，可溶性蛋白质和多肽从植物来源
公开(公告)号：EP1453608A2
公开(公告)日：2004-09-08
申请号：EP02770552.4
申请日：2002-10-02
CPC分类号： C12N15/8258 , C07K14/415 , C07K16/00 , C07K2317/13 , C07K2319/00 , C12N7/00 , C12N15/8203 , C12N15/8242 , C12N15/8257 , C12N2710/00051 , C12N2750/14151
摘要： A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible automated apparatus provides an efficient apparatus for isolating viruses, proteins and peptides of interest with little waste material. The automated apparatus for isolating viruses, proteins and peptides of interest includes a grinding apparatus (22) for homogenizing a plant to produce a green juice, a means for adjusting the pH of and heating the green juice, a means for separating the target species, either virus or protein/peptide, from other components of the green juice by one or more cycles of centrifugation, resuspension, and ultrafiltration, and finally purifying virus particles by such procedure as PEG-precipitation or purifying proteins and peptides by such procedures as chromatography and/or salt precipitation.
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10.发明公开
公开(公告)号：EP1358322A2
公开(公告)日：2003-11-05
申请号：EP02741635.3
申请日：2002-02-01
IPC分类号： C12N15/10
CPC分类号： C12N15/102 , C12N15/1027
摘要： We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective amount of enzymes having strand cleavage activity, 3' to 5' exonuclease activity, and polymerase activity, and allowing sufficient time for the percentage of complementarity to be increased within the heteroduplex. Not all heteroduplex polynucleotide will necessarily have all mismatches resolved to complementary. The resulting polynucleotide is optionally ligated. Several variant polynucleotide result. At sites where either of the opposite strands has templated recoding in the other strand, the resulting percent complementarity of the heteroduplex polynucleotide sequence is increased. The parent polynucleotides need not be cleaved into fragments prior to annealing heterologous strands. Therefore, no reassembly is required.
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