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24 条记录 (耗时 0.011 秒)

    INCREASING LIPID PRODUCTION IN OLEAGINOUS YEAST
    1.
    发明公开
    INCREASING LIPID PRODUCTION IN OLEAGINOUS YEAST 审中-公开

    公开(公告)号：EP3149153A4

    公开(公告)日：2017-11-29

    申请号：EP15800396

    申请日：2015-05-29

    申请人： NOVOGY INC

    发明人： TSAKRAKLIDES VASILIKI ,  BREVNOVA ELENA E

    IPC分类号： C12P7/64

    CPC分类号： C12P7/6463 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/20 ,  C12Y203/0102 ,  C12Y301/01003

    摘要： Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2) and increasing the activity of a type 2 diacylglycerol acyltransferase (i.e., DGA1). In some embodiments, the triacylglycerol content of a cell is also modified by decreasing the activity of a triacylglycerol lipase in the same cell. Also disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2), or by increasing the activity of a type 3 diacylglycerol acyltransferase (i.e., DGA3).

    MICROORGANISMS ENGINEERED TO USE UNCONVENTIONAL SOURCES OF PHOSPHORUS OR SULFUR
    6.
    发明公开
    MICROORGANISMS ENGINEERED TO USE UNCONVENTIONAL SOURCES OF PHOSPHORUS OR SULFUR 审中-公开
    磷素或使用非常规能源硫改造的微生物

    公开(公告)号：EP3039149A4

    公开(公告)日：2017-05-10

    申请号：EP14839721

    申请日：2014-08-27

    申请人： NOVOGY INC

    发明人： SHAW ARTHUR J ,  SOUTH COLIN R ,  VAN DIJKEN JOHANNES PIETER

    IPC分类号： C12P1/00 ,  C12N1/20

    CPC分类号： C12N9/0004 ,  C12P1/02 ,  C12P7/00 ,  C12Y120/01001

    摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical phosphorus or sulfur sources. Fermentation methods using the genetically engineered organisms are also described. The fermentation methods are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.

    摘要翻译： 公开的遗传改造的生物体，：如酵母和细菌，thathave代谢非典型磷或硫源的能力。 使用基因工程生物发酵方法被如此描述。 发酵方法可用于多种化合物，包括商品，精细化学品和药物的生物生产的工业过程健壮。

    REDUCING HORIZONTAL GENE TRANSFER OF FUNCTIONAL PROTEINS
    7.
    发明公开
    REDUCING HORIZONTAL GENE TRANSFER OF FUNCTIONAL PROTEINS 审中-公开
    REDUZIERUNG DES HORIZONTALEN GENTRANSFER VON FUNKELLELLEN PROTEINEN

    公开(公告)号：EP3114226A1

    公开(公告)日：2017-01-11

    申请号：EP15759140.5

    申请日：2015-03-03

    申请人： Novogy Inc.

    发明人： BREVNOVA, Elena, E. ,  GREENHAGEN, Emily, H. ,  SHAW, Arthur, J. ,  SOUTH, Colin, R.

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1055 ,  C12N15/52 ,  C12N15/65

    摘要： Disclosed are methods and compositions for reducing horizontal gene transfer of functional proteins. In some embodiments, the risk of horizontal gene transfer of a functional protein is reduced by separately encoding domains of a protein on at least two spatially distinct nucleic acid sequences, where each individual domain alone is non-functional, but co-expression of the encoded domains results in their association to form a functional protein.

    摘要翻译： 公开了减少功能蛋白水平基因转移的方法和组合物。 在一些实施方案中，通过在至少两个空间不同的核酸序列上单独编码蛋白质的结构域来降低功能性蛋白质的水平基因转移的风险，其中每个单独的结构域单独不是功能性的，而是编码的 结构域结合形成功能蛋白。