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    PROCESS FOR PRODUCING FARNESYLATED DIBENZODIAZEPINONE BY FERMENTATION
    3.
    发明公开
    PROCESS FOR PRODUCING FARNESYLATED DIBENZODIAZEPINONE BY FERMENTATION 审中-公开
    PROCEDURE发酵生产法尼基DIBENZODIAZEPINON的

    公开(公告)号：EP2013329A1

    公开(公告)日：2009-01-14

    申请号：EP07719556.8

    申请日：2007-04-16

    申请人： Thallion Pharmaceuticals Inc.

    发明人： PIRAEE, Mahmood ,  YEBOAH, Faustinus

    IPC分类号： C12N1/20 ,  B01D1/00 ,  B01D15/02 ,  B01D21/26 ,  B01D61/14 ,  C12P17/10

    CPC分类号： C12P17/10 ,  B01D15/00 ,  B01D61/145 ,  C07D243/38 ,  C12N1/20 ,  C12P17/12 ,  C12R1/29

    摘要： The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a Micromonospora species capable of producing a farnesylated dibenzodiazepinone at a high yield rate is provided, together with culture media for culturing microorganisms, and fermentation conditions for production of the farnesylated dibenzodiazepinone of the concentrate.

    POLYENE POLYKETIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS A PHARMACEUTICAL
    9.
    发明授权
    POLYENE POLYKETIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS A PHARMACEUTICAL 有权
    POLYENPOLYKETIDE，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS PHARMAZEUTIKUM

    公开(公告)号：EP1585752B1

    公开(公告)日：2007-11-21

    申请号：EP04703730.4

    申请日：2004-01-21

    申请人： Thallion Pharmaceuticals Inc.

    发明人： BACHMANN, Brian, O. ,  MCALPINE, James, B. ,  ZAZOPOULOS, Emmanuel ,  FARNET, Chris, M.

    IPC分类号： C07H15/203 ,  C07H15/26 ,  C07H15/10 ,  C07C229/30 ,  C07C237/16 ,  C12P19/44 ,  A61K31/7032 ,  A61P31/00

    CPC分类号： C07H15/203 ,  C07C215/24 ,  C07C225/14 ,  C07C235/28 ,  C07C237/16 ,  C07C279/22 ,  C07C305/14 ,  C07C2601/10 ,  C07C2601/14 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  C12P7/42 ,  C12P11/00 ,  C12P13/001 ,  C12P13/02 ,  C12P19/44 ,  C12R1/465 ,  Y10S435/886

    摘要： This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.

    摘要翻译： 本发明涉及新一类多烯聚酮化合物，其药学上可接受的盐和衍生物，以及获得化合物的方法。 获得这些化合物的一种方法是通过培养新的链霉菌链霉菌菌株; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及用于生产这些化合物的新型链霉菌Streptomyces aizunensis菌株，使用这些化合物及其药学上可接受的盐和衍生物作为药物，特别是其作为真菌细胞生长和癌细胞生长抑制剂的用途。 本发明还涉及包含这些新型聚酮化合物或其药学上可接受的盐或衍生物的药物组合物。 最后，本发明涉及参与这些新型聚酮化合物的生物合成的新型多核苷酸序列及其编码的蛋白质。