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1.发明公开THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO Ý3,2,1-IJ¨QUINOLINE COMPOUNDS 有权THERAPEUTIC的取代的HYDROPYRIDO [3,2,1-IJ]喹啉化合物
公开(公告)号：EP2294069A1
公开(公告)日：2011-03-16
申请号：EP09743667.9
申请日：2009-05-07
申请人： Allergan, Inc. , Sinha, Santosh C. , Bhat, Smita , Chow, Ken , Beard, Richard L. , Donello, John E. , Garst, Michael E.
发明人： SINHA, Santosh, C. , BHAT, Smita , CHOW, Ken , BEARD, Richard, L. , DONELLO, John, E. , GARST, Michael, E.
IPC分类号： C07D471/04 , C07D471/06 , C07D471/16 , A61P27/00 , A61P9/00 , A61K31/4745
CPC分类号： C07D471/06 , C07D471/04 , C07D471/16
摘要： Disclosed herein are compounds represented by the structural formula (I): therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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2.发明公开HETEROCYCLYL SUBSTITUTED FUSED CARBOCYLES USEFUL IN THE TREATMENT OF CONDITIONS SUCH AS GLAUCOMA AND PAIN 审中-公开FOR患青光眼和PAIN SUITABLE杂环基 - 取代的稠CARBO CYCLEN于治疗
公开(公告)号：EP2188262A1
公开(公告)日：2010-05-26
申请号：EP08797859.9
申请日：2008-08-14
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh, C. , BHAT, Smita, S. , HEIDELBAUGH, Todd, M. , GIL, Daniel, W. , CHOW, Ken , GARST, Michael, E.
IPC分类号： C07D233/50 , C07D263/28 , C07D277/18 , A61K31/4168
CPC分类号： C07D233/44 , C07D233/50 , C07D263/28 , C07D277/18
摘要： Disclosed herein is a compound having a structure (I), compositions, methods, and medicaments related thereto are also disclosed.
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3.发明公开ALKYNE AND ALKENE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE-1 RECEPTOR MODULATORS 审中-公开炔和烯衍生物ALS鞘氨醇-1-磷酸（S1P）受体调节剂
公开(公告)号：EP2646405A1
公开(公告)日：2013-10-09
申请号：EP11794320.9
申请日：2011-11-28
申请人： Allergan, Inc.
发明人： SINHA, Santosh, C. , BHAT, Smita, S. , CORPUZ, Evelyn, G. , CHOW, Ken , FANG, Wenkui, K. , IM, Wha, Bin
IPC分类号： C07C43/23 , C07C229/14 , C07F9/38 , A61K31/085 , A61K31/197 , A61K31/662 , A61P27/02
CPC分类号： C07C229/14 , C07C43/23 , C07F9/3808 , C07F9/3834 , C07F9/65515 , C07F9/655345
摘要： The present invention relates to novel alkyne and alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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4.发明公开
公开(公告)号：EP2240468A1
公开(公告)日：2010-10-20
申请号：EP09702233.9
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D233/48 , A61P25/00
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了可用作亚型选择性α2肾上腺素能激动剂的定义明确的杂环化合物。 如此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节有关的多种病症。
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公开(公告)号：EP2160386A1
公开(公告)日：2010-03-10
申请号：EP08755996.9
申请日：2008-05-21
申请人： ALLERGAN, INC.
IPC分类号： C07D401/06 , A61K31/4725 , A61P29/00
CPC分类号： C07D401/06
摘要： Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物还公开了与其相关的治疗方法，组合物和药物。
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6.发明授权METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS USING IMIDAZOLINE DERIVATIVES 有权使用咪唑啉衍生物治疗α肾上腺素能调节的方法
公开(公告)号：EP2303264B1
公开(公告)日：2018-04-04
申请号：EP09763343.2
申请日：2009-06-05
申请人： ALLERGAN, INC.
发明人： FANG, Wenkui, K. , NGUYEN, Phong, X. , CHOW, Ken , HEIDELBAUGH, Todd, M. , GOMEZ, Dario, G. , GARST, Michael, E. , SINHA, Santosh, C. , Daniel W. Gil , John E. Donello
IPC分类号： A61K31/4168 , A61P9/12
CPC分类号： A61K31/4168
摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.
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7.发明授权
公开(公告)号：EP2249834B1
公开(公告)日：2015-05-13
申请号：EP09702616.5
申请日：2009-01-15
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： A61K31/4439 , A61K31/497 , A61P29/00
CPC分类号： A61K31/4439 , A61K31/497
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8.发明授权
公开(公告)号：EP2240468B1
公开(公告)日：2013-10-16
申请号：EP09702233.9
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D233/48 , A61P25/00
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2190835B1
公开(公告)日：2012-10-03
申请号：EP08797844.1
申请日：2008-08-14
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh, C. , BHAT, Smita, S. , HEIDELBAUGH, Todd, M. , GIL, Daniel, W. , CHOW, Ken , GARST, Michael, E.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/435 , A61P29/00
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2303264A1
公开(公告)日：2011-04-06
申请号：EP09763343.2
申请日：2009-06-05
申请人： Allergan, Inc.
发明人： FANG, Wenkui, K. , NGUYEN, Phong, X. , CHOW, Ken , HEIDELBAUGH, Todd, M. , GOMEZ, Dario, G. , GARST, Michael, E. , SINHA, Santosh, C.
IPC分类号： A61K31/4168 , A61P9/12
CPC分类号： A61K31/4168
摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.
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