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    NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES
    2.
    发明公开
    NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES 有权
    NICHT-NATÜRLICHEAMINOSÄURENREPLIKATIONSABHÄNGIGEMIKROORGANISMEN UND IMPFSTOFFE

    公开(公告)号：EP2337846A4

    公开(公告)日：2012-08-08

    申请号：EP09817017

    申请日：2009-09-28

    申请人： AMBRX INC

    发明人： TIAN FENG ,  HEHLI BRAD

    IPC分类号： C12N1/36 ,  C12P21/00

    CPC分类号： C12N15/70 ,  A61K39/0258 ,  C12N1/36 ,  C12N9/93

    摘要： Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.

    摘要翻译： 包括制备疫苗的组合物和方法，包括通过使用非天然的，非天然的或非天然编码的氨基酸，使全生物疫苗具有有限的复制能力，从而提高疫苗的安全性和功效。

    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS
    5.
    发明公开
    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 有权
    HYBRID下HOUR-tRNA的电涡流动物细胞

    公开(公告)号：EP2061878A4

    公开(公告)日：2009-10-28

    申请号：EP07837971

    申请日：2007-09-07

    申请人： AMBRX INC

    发明人： TIAN FENG ,  NORMAN THEA ,  CHU STEPHANIE

    IPC分类号： C12N5/10 ,  C07H21/02 ,  C07H21/04 ,  C12N15/11 ,  C12P21/02

    CPC分类号： C12P21/02 ,  C12N9/93 ,  C12N15/11

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.

    METHODS AND COMPOSITIONS COMPRISING NON-NATURAL AMINO ACIDS
    10.
    发明公开
    METHODS AND COMPOSITIONS COMPRISING NON-NATURAL AMINO ACIDS 审中-公开
    方法和组合物非天然氨基酸

    公开(公告)号：EP1951890A4

    公开(公告)日：2009-06-24

    申请号：EP06837913

    申请日：2006-11-16

    申请人： AMBRX INC

    发明人： MIAO ZHENWEI ,  TIAN FENG ,  HAYS PUTNAM ANNA-MARIA A ,  BUECHLER YING

    IPC分类号： C12P21/06 ,  A61K38/00

    CPC分类号： G01N33/6812

    摘要： Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxy lamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.