MEDICAL IMPLANTS AND METHODS OF MAKING MEDICAL IMPLANTS
    1.
    发明公开
    MEDICAL IMPLANTS AND METHODS OF MAKING MEDICAL IMPLANTS 审中-公开
    的医学植入物及其制造方法的医学植入物

    公开(公告)号:EP2384206A2

    公开(公告)日:2011-11-09

    申请号:EP09805981.9

    申请日:2009-12-28

    IPC分类号: A61L31/08 A61L31/16 A61L31/10

    摘要: A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio- absorbable polymer and/ or pharmaceutical agent is deposited over the bioactive agent.

    METHOD FOR PRODUCING FILMS USING SUPERCRITICAL FLUID
    3.
    发明公开
    METHOD FOR PRODUCING FILMS USING SUPERCRITICAL FLUID 有权
    工艺生产具有超临界流体FILMS

    公开(公告)号:EP1507601A2

    公开(公告)日:2005-02-23

    申请号:EP03799811.9

    申请日:2003-05-27

    IPC分类号: B05D1/02 B05D1/06

    CPC分类号: B05D1/025 B05D5/083

    摘要: A method for forming a continuous film on a substrate surface that involves depositing particles onto a substrate surface and contacting the particle-deposited substrate surface with a supercritical fluid under conditions sufficient for forming a continuous film from the deposited particles. The particles may have a mean particle size of less 1 micron. The method may be performed by providing a pressure vessel that can contain a compressible fluid. A particle-deposited substrate is provided in the pressure vessel and the compressible fluid is maintained at a supercritical or sub-critical state sufficient for forming a film from the deposited particles. The Tg of particles may be reduced by subjecting the particles to the methods detailed in the present disclosure.