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公开(公告)号：EP3793559A1
公开(公告)日：2021-03-24
申请号：EP19725298.4
申请日：2019-05-10
发明人： MÜLLER, Steffen , SCHOHE-LOOP, Rudolf , ORTEGA, HERNANDEZ, Nuria , SÜSSMEIER, Frank , JIMENEZ NUNEZ, Eloisa , BRUMBY, Thomas , LINDNER, Niels , GERDES, Christoph , POOK, Elisabeth , BUCHMÜLLER, Anja , GAUGAZ, Fabienne, Zdenka , LANG, Dieter , ZIMMERMANN, Stefanie , EHRMANN, Alexander, Helmut, Michael , GERISCH, Michael , LEHMANN, Lutz , TIMMERMANN, Andreas , SCHÄFER, Martina , SCHMIDT, Georg , SCHLEMMER, Karl-Heinz , FOLLMANN, Markus , KERSTEN, Elisabeth , WANG, Vivian , GAO, Xiang , WANG, Yafeng
IPC分类号： A61K31/4985 , C07D487/04 , A61P27/02 , A61P7/00
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公开(公告)号：EP3452468A1
公开(公告)日：2019-03-13
申请号：EP17720501.0
申请日：2017-05-02
发明人： COLLIN-KRÖPELIN, Marie-Pierre , KOLKHOF, Peter , NEUBAUER, Thomas , FÜRSTNER, Chantal , POOK, Elisabeth , WITTWER, Matthias, Beat , LUSTIG, Klemens , BUCHMÜLLER, Anja , TINEL, Hanna , DRÖBNER, Karoline , MONDRITZKI, Thomas , SCHIRMER, Heiko , SCHMECK, Carsten , WASNAIRE, Pierre , CERMECKA, Hana , KRETSCHMER, Axel
IPC分类号： C07D403/06 , C07D403/14 , A61K31/4196 , A61P9/00 , A61P13/00
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公开(公告)号：EP3329920A3
公开(公告)日：2019-01-09
申请号：EP17208289.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
摘要： Die Erfindung betrifft Adrenorezeptor α2C Rezeptor Antagonisten zur Verwendung in einem Verfahren zur Behandlung und/oder Prophylaxe von Begleit- und/oder Folgeerkrankungen von Diabetes mellitus, diabetischen Herzerkrankungen, diabetischen koronaren Herzerkrankungen, diabetischen koronaren mikrovaskulären Herzerkrankungen, diabetischer Herzinsuffizienz, diabetischer Kardiomyopathie und Herzinfarkt, diabetischer Mikroangiopathie, diabetischer Retinopathie, diabetischer Neuropathie, diabetischer Nephropathie, diabetischer erektiler Dysfunktion, diabetischen Geschwüren an den Extremitäten, diabetischen Fußulzera, zur Förderung der diabetischen Wundheilung und zur Förderung der Wundheilung von diabetischen Fußulzera.
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公开(公告)号：EP3004084B1
公开(公告)日：2017-03-01
申请号：EP14727487.2
申请日：2014-05-30
发明人： ALLERHEILIGEN, Swen , BUCHMÜLLER, Anja , ENGEL, Karen , GERDES, Christoph , GERICKE, Kersten Matthias , GERISCH, Michael , HEITMEIER, Stefan , HILLISCH, Alexander , KINZEL, Tom , LIENAU, Philip , RIEDL, Bernd , RÖHRIG, Susanne , SCHMIDT, Martina Victoria , STRAßBURGER, Julia , TERSTEEGEN, Adrian
IPC分类号： C07D413/06 , C07D417/06 , C07D487/04 , C07D263/58 , A61K31/423 , A61P7/02
CPC分类号： C07D487/04 , A61K31/423 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/5377 , A61K31/5386 , C07D263/58 , C07D413/06 , C07D417/06
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公开(公告)号：EP3063150A1
公开(公告)日：2016-09-07
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D487/04 , A61K31/4188 , A61P7/02
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases. The oxopyridine derivatives inhibit factor XIa and plasma kallicrein.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及odemas以及眼科疾病的药物的用途 。
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公开(公告)号：EP3049390A1
公开(公告)日：2016-08-03
申请号：EP14771910.8
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert, Alan , SCHMIDT, Martina, Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D209/42 , A61P7/02 , A61K31/16 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , C07D209/42 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/04 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D487/04
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 除了使用所述衍生物生产用于治疗和/或预防疾病，特别是心血管疾病和/或围手术期严重失血的药物之外，本发明涉及取代的苯丙氨酸衍生物和其制备方法。
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7.发明公开
公开(公告)号：EP3004095A1
公开(公告)日：2016-04-13
申请号：EP14728514.2
申请日：2014-06-02
发明人： ALLERHEILIGEN, Swen , BUCHMÜLLER, Anja , ENGEL, Karen , GERDES, Christoph , GERICKE, Kersten Matthias , GERISCH, Michael , HEITMEIER, Stefan , HILLISCH, Alexander , KINZEL, Tom , LIENAU, Philip , RIEDL, Bernd , RÖHRIG, Susanne , SCHMIDT, Martina Victoria , STRASSBURGER, Julia , TERSTEEGEN, Adrian
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P19/10
CPC分类号： C07D471/04 , C07D519/00
摘要： The invention relates to substituted triazolopyridines and methods for the production thereof, as well as to the use thereof in the production of drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases.
摘要翻译： 本发明涉及取代的三唑并吡啶及其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞障碍的药物的用途。
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公开(公告)号：EP3004086A1
公开(公告)日：2016-04-13
申请号：EP14727212.4
申请日：2014-05-30
发明人： ALLERHEILIGEN, Swen , BUCHMÜLLER, Anja , ENGEL, Karen , GERDES, Christoph , GERICKE, Kersten Matthias , GERISCH, Michael , HEITMEIER, Stefan , HILLISCH, Alexander , KINZEL, Tom , LIENAU, Phlip , RIEDL, Bernd , RÖHRIG, Susanne , SCHMIDT, Martina Victoria , STRAßBURGER, Julia , TERSTEEGEN, Adrian
IPC分类号： C07D413/12 , C07D487/04 , A61K31/423 , A61P7/02
CPC分类号： C07D413/14 , C07D413/12 , C07D487/04
摘要： The invention relates to substituted benzoxazoles of formula (1) where R
1 stands for a group of formula, and a method for preparing same and their use in the production of drugs for the treatment and/or prevention of diseases, in particular cardiovascular diseases, preferably thrombotic or thromboembolic diseases.摘要翻译： 本发明涉及式（1）的取代的苯并恶唑类，其中R 1代表式的基团，其制备方法及其在制备用于治疗和/或预防疾病，特别是心血管疾病的药物中的用途， 优选血栓形成或血栓栓塞性疾病。
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公开(公告)号：EP2435428A1
公开(公告)日：2012-04-04
申请号：EP10721991.7
申请日：2010-05-14
发明人： HEIMBACH, Dirk , RÖHRIG, Susanne , CANCHO GRANDE, Yolanda , RESTER, Ulrich , BENDER, Eckhard , ZIMMERMANN, Katja , ZUBOV, Dmitry , BUCHMÜLLER, Anja , VON DEGENFELD, Georges , GERDES, Christoph , GNOTH, Mark, Jean , GERICKE, Kersten, Matthias , JESKE, Mario
IPC分类号： C07D413/06 , C07D417/06 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/34 , C07D401/06
CPC分类号： C07D211/34 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D401/06 , C07D417/06
摘要： The invention relates to novel substituted piperidines, to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and tumor diseases.
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公开(公告)号：EP2435405A1
公开(公告)日：2012-04-04
申请号：EP10721123.7
申请日：2010-05-18
发明人： HEIMBACH, Dirk , RÖHRIG, Susanne , CANCHO GRANDE, Yolanda , RESTER, Ulrich , BENDER, Eckhard , ZIMMERMANN, Katja , ZUBOV, Dmitry , BUCHMÜLLER, Anja , VON DEGENFELD, Georges , GERDES, Christoph , GNOTH, Mark, Jean , GERICKE, Kersten, Matthias , JESKE, Mario
IPC分类号： C07D211/18 , C07D401/06 , A61K31/451 , A61K31/4545 , A61P9/00 , A61P35/00
CPC分类号： C07D401/06 , C07D211/18
摘要： The invention relates to novel substituted piperidines, to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and tumor diseases.
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