公开(公告)号：EP3793559A1

公开(公告)日：2021-03-24

申请号：EP19725298.4

申请日：2019-05-10

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： MÜLLER, Steffen ,  SCHOHE-LOOP, Rudolf ,  ORTEGA, HERNANDEZ, Nuria ,  SÜSSMEIER, Frank ,  JIMENEZ NUNEZ, Eloisa ,  BRUMBY, Thomas ,  LINDNER, Niels ,  GERDES, Christoph ,  POOK, Elisabeth ,  BUCHMÜLLER, Anja ,  GAUGAZ, Fabienne, Zdenka ,  LANG, Dieter ,  ZIMMERMANN, Stefanie ,  EHRMANN, Alexander, Helmut, Michael ,  GERISCH, Michael ,  LEHMANN, Lutz ,  TIMMERMANN, Andreas ,  SCHÄFER, Martina ,  SCHMIDT, Georg ,  SCHLEMMER, Karl-Heinz ,  FOLLMANN, Markus ,  KERSTEN, Elisabeth ,  WANG, Vivian ,  GAO, Xiang ,  WANG, Yafeng

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P27/02 ,  A61P7/00

公开(公告)号：EP2773375B1

公开(公告)日：2017-02-08

申请号：EP12779063.2

申请日：2012-10-29

申请人： Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KRENZ, Ursula

IPC分类号： A61K47/65 ,  C07K5/02 ,  C07K5/068 ,  C07K5/09

CPC分类号： C07K5/0815 ,  A61K38/05 ,  A61K38/06 ,  A61K47/50 ,  A61K47/65 ,  C07K5/0215 ,  C07K5/06086

公开(公告)号：EP3083594A1

公开(公告)日：2016-10-26

申请号：EP14815662.3

申请日：2014-12-16

申请人： Bayer Pharma Aktiengesellschaft

发明人： BECKER-PELSTER, Eva Maria ,  BUCHGRABER, Philipp ,  BUCHMÜLLER, Anja ,  ENGEL, Karen ,  GNOTH, Mark Jean ,  HIMMEL, Herbert ,  KAST, Raimund ,  KLAR, Jürgen ,  KNORR, Andreas ,  LANG, Dieter ,  LINDNER, Niels ,  SCHMECK, Carsten ,  SCHOHE-LOOP, Rudolf ,  TINEL, Hanna ,  TRÜBEL, Hubert ,  WUNDER, Frank

IPC分类号： C07D401/14 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D401/12 ,  C07D403/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  A61K31/4468 ,  A61K31/4523 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07D211/10 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D211/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.

公开(公告)号：EP3075395A1

公开(公告)日：2016-10-05

申请号：EP15192265.5

申请日：2012-10-30

申请人： Bayer Pharma Aktiengesellschaft ,  Bayer Intellectual Property GmbH

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KÖLLNBERGER, Maria ,  WUNDER, Frank ,  REDLICH, Gordon ,  KNORR, Andreas ,  MARLEY, July ,  PRITCHARD, Iain

IPC分类号： A61K47/48 ,  A61K38/23 ,  A61P9/00 ,  A61P29/00 ,  A61P11/00

CPC分类号： C07K5/06017 ,  A61K9/007 ,  A61K38/22 ,  A61K45/06 ,  A61K47/60 ,  C07K5/02 ,  C07K5/06078 ,  C07K14/575

摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.

摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂合物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。

公开(公告)号：EP2773375A1

公开(公告)日：2014-09-10

申请号：EP12779063.2

申请日：2012-10-29

申请人： Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KRENZ, Ursula

IPC分类号： A61K47/48 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08

CPC分类号： C07K5/0815 ,  A61K38/05 ,  A61K38/06 ,  A61K47/50 ,  A61K47/65 ,  C07K5/0215 ,  C07K5/06086

摘要： The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.

公开(公告)号：EP3075395B1

公开(公告)日：2017-11-22

申请号：EP15192265.5

申请日：2012-10-30

申请人： Bayer Pharma Aktiengesellschaft ,  Bayer Intellectual Property GmbH

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KÖLLNBERGER, Maria ,  WUNDER, Frank ,  REDLICH, Gorden ,  KNORR, Andreas ,  MARLEY, July ,  PRITCHARD, Iain

IPC分类号： A61K47/59 ,  A61K38/22 ,  A61K9/00 ,  A61P9/00 ,  A61P29/00 ,  A61P11/00

CPC分类号： C07K5/06017 ,  A61K9/007 ,  A61K38/22 ,  A61K45/06 ,  A61K47/60 ,  C07K5/02 ,  C07K5/06078 ,  C07K14/575

摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.

公开(公告)号：EP2773376B1

公开(公告)日：2016-01-13

申请号：EP12783566.8

申请日：2012-10-30

申请人： Bayer Pharma Aktiengesellschaft ,  Bayer Intellectual Property GmbH

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KÖLLNBERGER, Maria ,  WUNDER, Frank ,  REDLICH, Gorden ,  KNORR, Andreas ,  MARLEY, July ,  PRITCHARD, Iain

IPC分类号： A61K47/48 ,  A61K38/22 ,  A61P9/00 ,  A61P29/00 ,  A61P11/00

CPC分类号： C07K5/06017 ,  A61K9/007 ,  A61K38/22 ,  A61K45/06 ,  A61K47/60 ,  C07K5/02 ,  C07K5/06078 ,  C07K14/575

摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.

摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂化物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。

公开(公告)号：EP2773376A1

公开(公告)日：2014-09-10

申请号：EP12783566.8

申请日：2012-10-30

申请人： Bayer Pharma Aktiengesellschaft ,  Bayer Intellectual Property GmbH

发明人： FLAMME, Ingo ,  KÖBBERLING, Johannes ,  LERCHEN, Hans-Georg ,  GRIEBENOW, Nils ,  SCHOHE-LOOP, Rudolf ,  WITTROCK, Sven ,  KÖLLNBERGER, Maria ,  WUNDER, Frank ,  REDLICH, Gorden ,  KNORR, Andreas ,  MARLEY, July ,  PRITCHARD, Iain

IPC分类号： A61K47/48 ,  A61K38/23 ,  A61P9/00 ,  A61P29/00 ,  A61P11/00

CPC分类号： C07K5/06017 ,  A61K9/007 ,  A61K38/22 ,  A61K45/06 ,  A61K47/60 ,  C07K5/02 ,  C07K5/06078 ,  C07K14/575

摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.

公开(公告)号：EP1339403A2

公开(公告)日：2003-09-03

申请号：EP01989448.4

申请日：2001-11-09

申请人： Bayer Aktiengesellschaft

发明人： KROLL, Werner ,  ROMBOUT, Ferdinand ,  WEBER, Horst ,  RODRIGUEZ, Maria-Luisa ,  SENNHENN, Bernd ,  SCHOHE-LOOP, Rudolf

IPC分类号： A61K31/35 ,  A61K31/425 ,  G01N33/94

CPC分类号： C07D417/12 ,  G01N33/94

摘要： The invention relates to a kit comprising a pharmaceutical composition that contains repinotan or a physiologically acceptable salt of repinotan, and to a means for determining the concentration of repinotan or its metabolites in body fluids. The invention further relates to novel pharmaceutical compositions that contain repinotan or a physiologically acceptable salt of repinotan, and to a method for producing the same.

摘要翻译： 本发明涉及一种试剂盒，其包含含有肾上腺素或生理上可接受的肾上腺素盐的药物组合物，并涉及测定体液中肾上腺素或其代谢物浓度的方法。 本发明进一步涉及新颖的药物组合物及其生产方法，所述药物组合物含有瑞宁辛（repinotan）或生理上可接受的瑞宁诺坦盐。