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1.发明授权AUSGEWAHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 有权AUSGEWAHLTE CGRP-ANTAGONISTEN，VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL
公开(公告)号：EP1732917B1
公开(公告)日：2009-07-29
申请号：EP05741783.4
申请日：2005-03-23
发明人： MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , DREYER, Alexander , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard , SANTAGOSTINO, Marco , PALEARI, Fabio
IPC分类号： C07D401/04 , C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D471/04 , C07D495/04
摘要： The invention relates to CGRP antagonists of general formula (I), in which A, X, D, E, G, M, Q and R1 to R3 are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and their salts as well as the hydrates of the salts, particularly their physiologically compatible salts having inorganic or organic acids, to medicaments containing these compounds, to their use, and to methods for the production thereof.
摘要翻译： 本发明涉及通式（I）的CGRP拮抗剂，其中A，X，D，E，G，M，Q和R 1至R 3如权利要求1中所定义，其互变异构体，异构体，非对映异构体，对映异构体，水合物 ，它们的混合物和它们的盐以及盐的水合物，特别是它们的具有无机酸或有机酸的生理上相容的盐，含有这些化合物的药物，它们的用途，以及它们的生产方法。
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2.发明授权NEUE ALKIN-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权新ALKIN CONNECTIONS MCH拮抗作用及药物含有它们的
公开(公告)号：EP1558578B1
公开(公告)日：2013-03-13
申请号：EP03809734.1
申请日：2003-10-25
发明人： MÜLLER, Stephan-Georg , STENKAMP, Dirk , ARNDT, Kirsten , ROTH, Gerald, Juergen , LOTZ, Ralf, Richard, Hermann , LEHMANN-LINTZ, Thorsten , LENTER, Martin , LUSTENBERGER, Philipp , RUDOLF, Klaus
IPC分类号： C07D213/30 , C07D401/12 , C07D405/06 , C07D401/06 , C07D213/40 , C07D401/10 , C07D213/38 , C07D401/14 , C07D213/55 , C07D213/56 , C07D213/61 , C07D213/53 , A61K31/4375 , A61P3/04 , C07D213/42 , C07D213/48 , C07D213/57 , C07D213/65
CPC分类号： C07D213/48 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/85 , C07D215/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D333/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/06 , C07D453/02 , C07D471/04 , C07D471/10 , C07D487/08 , C07D487/10 , C07D495/04
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3.发明公开(HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开（杂）与MCH拮抗作用和芳基化合物药物同这些链接
公开(公告)号：EP1943231A1
公开(公告)日：2008-07-16
申请号：EP06807530.8
申请日：2006-10-25
发明人： ROTH, Gerald Juergen , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , LUSTENBERGER, Philipp , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D237/08 , A61K31/501 , A61P3/04
CPC分类号： C07D237/08
摘要： The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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4.发明公开2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-YL-PIPERIDINE ALS CGRP-ANTAGONISTEN 有权2-氧代-1,2,4,5-四氢-1,3-苯并二氮杂-3-基 - 哌啶ALS CGRP拮抗剂
公开(公告)号：EP1863791A1
公开(公告)日：2007-12-12
申请号：EP06723571.3
申请日：2006-03-21
发明人： MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , SANTAGOSTINO, Marco , PALEARI, Fabio , DREYER, Alexander , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/04 , C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to novel CGRP antagonists of general formula (I), in which B, R1 and R2 are defined as cited in claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts, in addition to the hydrates of their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases. The invention also relates to medicaments containing said compounds, to their use and to a method for their production.
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公开(公告)号：EP1856070A1
公开(公告)日：2007-11-21
申请号：EP06708325.3
申请日：2006-02-16
IPC分类号： C07D265/18 , A61K31/536
CPC分类号： C07D265/18
摘要： The invention concerns the use of compounds of formula (I), wherein the radicals R1, R2 and R3 are such as defined in the description and the claims, for producing a drug for treating respiratory diseases as well as novel compounds of formula (I). The invention also concerns a method for producing said compounds, and pharmaceutical formulations containing them.
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6.发明公开
公开(公告)号：EP1747208A1
公开(公告)日：2007-01-31
申请号：EP05740022.8
申请日：2005-05-10
发明人： BOUYSSOU, Thierry , SCHNAPP, Andreas , LUSTENBERGER, Philipp , RUDOLF, Klaus , PIEPER, Michael, P. , GRAUERT, Matthias , BREITFELDER, Steffen , SPECK, Georg
IPC分类号： C07D265/36 , C07D471/08 , A61K31/538 , A61P11/00
CPC分类号： C07D265/36 , C07D471/08
摘要： The invention relates to the compounds of general formula (1), wherein the groups n, A, B, D, L, R1, R2, R3 and R4 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of respiratory diseases.
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7.发明公开AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 有权AUSGEWÄHLTECGRP-ANTAGONISTEN，VERFAHREN ZU德仁HERSTELLUNG SOWIE德仁VERWENDUNG ALS医药有限公司
公开(公告)号：EP1737842A1
公开(公告)日：2007-01-03
申请号：EP05731650.7
申请日：2005-04-09
发明人： MUELLER, Stephan Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/14 , C07D471/10 , C07D513/04 , C07D453/04 , C07D401/04 , C07D451/04 , C07D471/04 , C07D495/04 , C07D487/08 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04 , C07D451/04 , C07D453/02 , C07D487/04 , C07D487/08
摘要： The invention relates to the CGRP antagonists of general formula (I), wherein A, X and R1 to R3 are defined as in claim 1. The invention also relates to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and to the hydrates of said salts, especially their physiologically acceptable salts with inorganic or organic acids, to drugs comprising said compounds, to their use and to a method for producing the same.
摘要翻译： 本发明涉及通式（I）的CGRP拮抗剂，其中A，X和R 1 -R 3如权利要求1中所定义。本发明还涉及其互变异构体，非对映异构体，对映异构体，水合物，混合物和盐以及 所述盐的水合物，特别是其与无机酸或有机酸的生理学上可接受的盐，包含所述化合物的药物，它们的用途及其制备方法。
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8.发明公开
公开(公告)号：EP1737823A2
公开(公告)日：2007-01-03
申请号：EP05737015.7
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan, Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , ROTH, Gerald, Jürgen , RUDOLF, Klaus , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf, R., H.
IPC分类号： C07D213/00
CPC分类号： C07D213/30 , C07D213/38 , C07D213/74 , C07D213/75 , C07D401/06 , C07D401/10 , C07D401/12 , C07D409/10 , C07D409/14 , C07D451/06
摘要： The invention relates to individual alkyne compounds with an antagonistic action against the MCH-receptor. Said compounds are suitable for producing medicaments for the treatment of metabolic disorders and/or eating disorders, in particular adiposity and diabetes.
摘要翻译： 本发明涉及对MCH受体具有拮抗作用的单独的炔烃化合物。 所述化合物适用于生产用于治疗代谢紊乱和/或进食障碍，特别是肥胖症和糖尿病的药物。
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9.发明授权ARZNEINMITTELKOMBINATIONEN ENTHALTEND BENZOXAZINE ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 有权药制剂含组合苯并恶嗪呼吸系统疾病的治疗
公开(公告)号：EP1781298B1
公开(公告)日：2012-01-04
申请号：EP05739576.6
申请日：2005-04-18
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , PIEPER, Michael, P. , PAIRET, Michel
IPC分类号： A61K31/538 , A61P11/06 , A61K45/06
CPC分类号： A61K45/06 , A61K31/538 , A61K2300/00
摘要： The invention relates to novel pharmaceutical combinations containing at least one active ingredient (2) in addition to at least one, preferably one, compound of general formula (1) wherein the radicals R1, R2 and R3 have the designations cited in the patent claims and in the description. The invention also relates to a method for producing said combinations and to the use thereof as medicaments.
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10.发明授权NEUE AMID-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权牛奶维生素MIT-ANTAGONISTISCHER WIRKUNG UNDERE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL
公开(公告)号：EP1558567B1
公开(公告)日：2009-06-24
申请号：EP03778292.7
申请日：2003-10-28
发明人： STENKAMP, Dirk , MÜLLER, Stephan, Georg , ROTH, Gerald, Jürgen , LUSTENBERGER, Philipp , RUDOLF, Klaus , LEHMANN-LINTZ, Thorsten , ARNDT, Kirsten , LOTZ, Ralf, R., H. , LENTER, Martin , WIELAND, Heike-Andrea
IPC分类号： C07C233/29 , C07C235/24 , C07C237/04 , C07C255/60 , C07D207/08 , C07D207/20 , C07D209/08 , C07D211/62 , C07D213/30 , C07D213/56 , C07D295/08 , C07D295/12 , C07D307/42 , C07D333/16 , A61K31/16 , A61K31/33 , A61P3/00
CPC分类号： C07D213/30 , C07C233/29 , C07C235/24 , C07C237/04 , C07C255/60 , C07C275/32 , C07C2601/14 , C07D207/09 , C07D207/20 , C07D209/08 , C07D211/46 , C07D211/62 , C07D213/56 , C07D295/03 , C07D295/088 , C07D295/13 , C07D307/42 , C07D333/16
摘要： The invention relates to amide compounds of general formula (I), in which the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. The invention further relates to medicaments comprising at least one of said amides. Said medicaments are suitable for the treatment of metabolic disorders and/or eating disorders, in particular, obesity, bulimia, anorexia, hyperphagia, and diabetes as a result of the MCH receptor antagonism.
摘要翻译： 本发明涉及通式（I）的酰胺化合物，其中基团和残基A，B，b，W，X，Y，Z，R 1，R 2和R 3具有如下含义： 本发明还涉及包含至少一种所述酰胺的药物。 所述药物适合于作为MCH受体拮抗作用的结果来治疗代谢紊乱和/或进食障碍，特别是肥胖，食欲过剩，厌食，食欲过盛和糖尿病。
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