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    SYSTEM AND METHOD FOR PRODUCING TARGET BIOLOGICAL SUBSTANCES
    1.
    发明公开
    SYSTEM AND METHOD FOR PRODUCING TARGET BIOLOGICAL SUBSTANCES 审中-公开

    公开(公告)号：EP3712612A1

    公开(公告)日：2020-09-23

    申请号：EP20174012.3

    申请日：2013-11-20

    申请人： Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Vilnius University

    发明人： ITALIANO, Joseph ,  MAZUTIS, Linas ,  THON, Jonathan N. ,  WEITZ, David A.

    IPC分类号： G01N33/48 ,  B01L3/00

    摘要： A biomimetic microfluidic system and a method are provided for producing target biological substances. The system comprises a first channel extending from a first input to a first output along a longitudinal dimension. The first channel is configured to receive at least one first biological composition at a first channel flow rate. The at least one first biological composition comprises a biological source material capable of producing target biological substances. The system further comprises a second channel substantially parallel to the first channel, extending from a second input to a second output along the longitudinal dimension. The second channel is configured to selectively receive at least one second biological composition at a second channel flow rate. The system further comprises a separation barrier between the first channel and the second channel. The separation barrier has a plurality of microchannels forming a fluid communication path between the first and second channels.

    CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS
    4.
    发明公开
    CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 有权
    芫荽粉，茉莉酸

    公开(公告)号：EP2714254A2

    公开(公告)日：2014-04-09

    申请号：EP12725967.9

    申请日：2012-05-22

    申请人： President and Fellows of Harvard College ,  BASF SE

    发明人： ROTEM, Assaf ,  WEITZ, David A. ,  ABATE, Adam R. ,  HOLTZE, Christian

    IPC分类号： B01F13/00 ,  B01F3/08

    CPC分类号： B01F3/0811 ,  B01F3/0807 ,  B01F13/0062 ,  B01F13/0084 ,  Y10T137/87571

    摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels, where a first fluid flows through one channel, a second fluid flows through two channels, and a third or carrying fluid flows through two more channels, such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

    摘要翻译： 本发明一般涉及乳液，更具体地说涉及双重和其它多重乳液。 本发明的某些方面通常涉及在微流体通道的共同连接处产生双重乳液和其它多重乳液。 在一些情况下，共同连接处的微流体通道可具有基本上相同的疏水性。 在一组实施例中，装置可以包括六个或更多个通道的公共接头，其中第一流体流过一个通道，第二流体流过两个通道，并且第三或承载流体流过两个以上通道，使得 包含在第二流体的第二液滴中的第一流体的第一液滴的双重乳液由携带流体包含，通过第六通道从公共接头流出。

    FLUID INJECTION
    5.
    发明公开
    FLUID INJECTION 审中-公开

    公开(公告)号：EP4019977A1

    公开(公告)日：2022-06-29

    申请号：EP21208171.5

    申请日：2010-06-25

    申请人： President and Fellows of Harvard College

    发明人： WEITZ, David A. ,  ABATE, Adam R. ,  HUNG, Tony ,  MARY, Pascaline

    IPC分类号： G01N35/10 ,  B01J19/00 ,  B01F25/314 ,  B01F33/3031

    摘要： Systems (200) and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet (220) contained within a fluidic channel (230), or a fluid may be injected into a fluidic channel to create a droplet (220). In some embodiments, electrodes (250) may be used to apply an electric field to one or more fluidic channels (230,240), e.g., proximate an intersection of at least two fluidic channels (230, 240). For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    FORMATION AND CONTROL OF FLUIDIC SPECIES
    6.
    发明公开
    FORMATION AND CONTROL OF FLUIDIC SPECIES 审中-公开

    公开(公告)号：EP3616781A1

    公开(公告)日：2020-03-04

    申请号：EP19196999.7

    申请日：2004-04-09

    申请人： President and Fellows of Harvard College

    发明人： LINK, Darren R. ,  WEITZ, David A. ,  MARQUEZ-SANCHEZ, Manuel ,  CHENG, Zhengdong

    IPC分类号： B01F13/00 ,  B01F5/06 ,  B01J2/04 ,  B05B7/06 ,  B05B5/025 ,  B05B5/03

    摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.