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公开(公告)号：EP3999136A1
公开(公告)日：2022-05-25
申请号：EP20740033.4
申请日：2020-07-17
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公开(公告)号：EP2117612B2
公开(公告)日：2018-11-21
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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公开(公告)号：EP2403544B1
公开(公告)日：2018-11-14
申请号：EP10706257.2
申请日：2010-03-03
发明人： BUJOLI, Bruno , BOULER, Jean-Michel , JANVIER, Pascal , KHAIROUN, Ibrahim , SCHNITZLER, Verena , MELLIER, Charlotte
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0
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公开(公告)号：EP2240214A2
公开(公告)日：2010-10-20
申请号：EP09701360.1
申请日：2009-01-06
发明人： LEGUEN, Hervé , CAVAGNA, Rémi , KHAIROUN, Ibrahim , VERRON, Elise , JANVIER, Pascal , GAUTHIER, Olivier , BOULER, Jean-Michel
CPC分类号： A61K47/02 , A61K9/0024 , A61K9/0063 , A61K9/19 , A61K31/00 , A61K31/167 , A61K31/445 , A61L24/0015 , A61L24/02 , A61L27/12 , A61L27/54 , A61L2300/402
摘要： The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.
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5.发明授权
公开(公告)号：EP2117612B1
公开(公告)日：2015-07-29
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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6.发明授权MACROPOROUS AND HIGHLY RESORBABLE APATITIC CALCIUM-PHOSPHATE CEMENT 有权MAKROPORÖSERUND HOCH RESORBIERBARER APATITISCHER钙钙磷酸盐
公开(公告)号：EP2054090B1
公开(公告)日：2015-10-07
申请号：EP07804808.9
申请日：2007-08-23
申请人： Graftys , UNIVERSITE DE NANTES
CPC分类号： A61L27/46 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0084 , A61L27/56 , A61L27/58 , A61L2430/02
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7.发明公开
公开(公告)号：EP2117612A1
公开(公告)日：2009-11-18
申请号：EP08716830.8
申请日：2008-02-13
发明人： BOULER, Jean-Michel , BUJOLI, Bruno , JANVIER, Pascal , KHAIROUN, Ibrahim , ARGENSON, Jean-Noël
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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8.发明公开
公开(公告)号：EP2054090A1
公开(公告)日：2009-05-06
申请号：EP07804808.9
申请日：2007-08-23
申请人： Graftys , UNIVERSITE DE NANTES
CPC分类号： A61L27/46 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0084 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.
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公开(公告)号：EP1480687B1
公开(公告)日：2009-02-11
申请号：EP03717407.5
申请日：2003-02-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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10.发明公开
公开(公告)号：EP1480687A1
公开(公告)日：2004-12-01
申请号：EP03717407.5
申请日：2003-02-18
申请人： Centre National de la Recherche Scientifique , Universite de Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BUJOLI, Bruno , JOSSE, Solen , GUICHEUX, Jérôme , JANVIER, Pascal , BOULER, Jean-Michel , DACULSI, Guy
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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