-
公开(公告)号：EP1392283A4
公开(公告)日：2004-10-20
申请号：EP02731803
申请日：2002-05-16
申请人： CYTOVIA INC , SHIRE BIOCHEM INC
发明人： CAI SUI XIONG , ZHANG HONG , KEMNITZER WILLIAM E , JIANG SONGCHUN , DREWE JOHN A , STORER RICHARD
IPC分类号： A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D335/06 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04 , A61P35/00 , C07D215/16 , C07D215/20 , C07D311/04 , C07D335/04
CPC分类号： C07D335/06 , A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
-
2.发明公开SUBSTITUTED 1-BENZOYL-3-CYANO-PYRROLO 1,2-A| QUINOLINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开SUBSTITUIERTE1苯甲酰基-3-CYANOPYRROLO¬1,2-A | CHINO亚麻及其类似物的半胱氨酸蛋白酶激活因子和细胞凋亡INDUCTORS
公开(公告)号：EP1578424A4
公开(公告)日：2007-08-08
申请号：EP03813401
申请日：2003-12-12
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN A , JIANG SUNGCHUN , KASIBHATLA SHAILAJA , KUEMMERLE JARED DANIEL , SIRISOMA NILANTHA SUDATH , ZHANG HAN-ZHONG
IPC分类号： C07D471/04 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/4985 , C07D471/06 , C07D471/14 , C07D487/04 , C07D487/06 , C07D487/12
CPC分类号： C07D471/04 , A61K31/4745 , A61K31/496 , A61K31/4985 , C07D471/14 , C07D487/04
-
3.发明公开NOVEL FLUORESCENCE DYES AND THEIR APPLICATIONS FOR WHOLE CELL FLUORESCENCE SCREENING ASSAYS FOR CASPASES, PEPTIDASES, PROTEASES AND OTHER ENZYMES AND THE USE THEREOF 有权新的荧光染料及其在FLUORESZENSNACHWEISVERFAHREN应用的所有单元格FOR胱天蛋白酶，肽酶，蛋白酶和其他酶及其用途
公开(公告)号：EP1100520A4
公开(公告)日：2002-07-17
申请号：EP99935751
申请日：1999-07-21
申请人： CYTOVIA INC
发明人： ZHANG HAN-ZHONG , CAI SUI XIONG , DREWE JOHN A , YANG WU
IPC分类号： C07D311/82 , C07D493/10 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/06 , A61K38/00 , A61K38/04 , A61K38/08 , C07D309/00 , C07D311/78 , C12N9/48 , C12N9/50 , C12Q1/37 , G01N33/53
CPC分类号： C07D493/10 , C07D311/82 , C07K5/06191 , C07K5/0827 , C07K5/1027 , C07K7/06 , Y10T436/142222
摘要： The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzymes assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.
-
4.发明公开SUBSTITUTED 4-ARYL-CHROMENE AS ACTIVATOR OF CASPASES AND INDUCER OF APOPTOSIS AND AS ANTIVASCULAR AGENT AND THE USE THEREOF 审中-公开取代的4-芳基 - 色烯ALS胱天蛋白酶激活剂，细胞凋亡INDUCTOR和抗血管AGENTS AND USE
公开(公告)号：EP2049101A4
公开(公告)日：2010-09-15
申请号：EP07810283
申请日：2007-07-06
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN A , KASIBHATLA SHAILAJA , KEMNITZER WILLIAM E , TSENG BEN Y , LABRECQUE DENIS , BLAIS CHARLES , GOURDEAU HENRIETTE
IPC分类号： A61K31/353 , C07D311/58
CPC分类号： C07D405/12 , C07D311/58
-
5.发明公开SUBSTITUTED 3-ARYL-5-ARYL- 1,2,4 -OXADIAZOLES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开取代的3-芳基-5-芳基-1,2,4-恶二唑及其类似物作为与细胞凋亡胱天蛋白酶的活化剂的电感器和它们的用途
公开(公告)号：EP1406632A4
公开(公告)日：2009-11-04
申请号：EP02753336
申请日：2002-06-10
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , ZHANG HAN-ZHONG , DREWE JOHN A , REDDY P SANJEEVA , KASIBHATLA SHAILAJA , KUEMMERLE JARED DANIEL , OLLIS KRISTIN P
IPC分类号： C07D487/04 , A61K31/335 , A61K31/38 , A61K31/395 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/54 , A61P1/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , A61K31/415 , A61K31/4166 , A61K31/424 , A61K31/495 , A61K31/538 , A61K31/541 , A61K31/5415
CPC分类号： C07D413/14 , A61K31/335 , A61K31/38 , A61K31/395 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04
-
6.发明公开3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开3-芳基-6-芳基 - 7H- [1,2,4]三唑并[3,4-b] [1,3,4]噻二嗪和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
公开(公告)号：EP2046336A4
公开(公告)日：2010-12-15
申请号：EP07796912
申请日：2007-07-18
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN A , ZHANG HAN-ZHONG , KASIBHATLA SHAILAJA , CLAASSEN GISELA , SIRISOMA NILANTHA SUDATH , KEMNITZER WILLIAM EDWARD
IPC分类号： A61K31/53 , A61K31/5365 , A61K31/542
CPC分类号： A61K31/53 , A61K31/542 , C07D487/04 , C07D513/04
-
7.发明公开SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开取代的2-芳基-4- ARYLAMINOPYRIMIDINE AND ANALOG如胱天蛋白酶和细胞凋亡诱导的活化剂，其使用
公开(公告)号：EP1351691A4
公开(公告)日：2005-06-22
申请号：EP01990048
申请日：2001-12-12
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN A , NGUYEN BAO , REDDY P SANJEEVA , PERVIN AZRA
IPC分类号： A61K31/50 , A61K31/505 , A61K31/53 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D417/14
CPC分类号： C07D239/42 , A61K31/50 , A61K31/505 , A61K31/53 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D417/14
-
8.发明公开NOVEL FLUORESCENT REPORTER MOLECULES AND THEIR APPLICATIONS INCLUDING ASSAYS FOR CASPASES 审中-公开荧光显示MOLOKÜLE和应用，包括CASPASEDOSIERUNG
公开(公告)号：EP1026988A4
公开(公告)日：2005-03-30
申请号：EP98953317
申请日：1998-10-09
申请人： CYTOVIA INC
发明人： WEBER ECKARD , CAI SUI XIONG , KEANA JOHN F W , DREWE JOHN A , ZHANG HAN-ZHONG
IPC分类号： G01N33/50 , C07K1/13 , C07K5/06 , C07K5/062 , C07K5/083 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/113 , C12P17/06 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N15/10 , G01N15/14 , G01N33/15 , G01N33/533 , G01N33/574 , A61B8/00 , C12Q1/00 , C12Q1/37 , G01N33/48 , G01N33/58
CPC分类号： C07K5/06026 , C07K5/06052 , C07K5/0806 , C07K5/0808 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C12Q1/68 , G01N15/1456 , G01N33/533 , G01N2015/1006 , G01N2015/1488 , Y02P20/55
摘要： The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.
-
公开(公告)号：EP1033910A4
公开(公告)日：2004-11-24
申请号：EP98952166
申请日：1998-10-09
申请人： CYTOVIA INC
发明人： KEANA JOHN F W , CAI SUI XIONG , GUASTELLA JOHN , YANG WU , DREWE JOHN A
IPC分类号： C12N1/04 , A61K38/00 , A61P3/10 , A61P7/06 , A61P9/04 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , C07C237/12 , C07C237/22 , C07C271/22 , C07C323/59 , C07C323/60 , C07D233/54 , C07D277/16 , C07K5/06 , C12N5/00 , A01N1/02 , A61K38/05 , C12N5/02
CPC分类号： C07D233/64 , A61K38/00 , C07C237/22 , C07C271/22 , C07C323/60 , C07D277/16 , C07K5/06191 , C12N2810/40
-
10.发明公开DERIVATIVES OF GAMBOGIC ACID AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开藤黄酸和半胱氨酸蛋白酶的类似物作为资产盖茨衍生物和手段释放细胞凋亡
公开(公告)号：EP1562598A4
公开(公告)日：2010-02-03
申请号：EP03748924
申请日：2003-07-01
申请人： CYTOVIA INC
发明人： TSENG BEN , SIRISOMA NILANTHA SUDATH , CAI SUI XIONG , ZHANG HAN-ZHONG , KASIBHATLA SHAILAJA , OLLIS KRISTIN P , DREWE JOHN A
IPC分类号： A61K31/45 , A61K31/497 , A61P31/12 , A61P35/00 , A61P37/06 , C07D493/20 , C12N5/02
CPC分类号： A61K31/00 , C07D493/20
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.012 秒)
