公开(公告)号：EP1479670A4

公开(公告)日：2006-03-08

申请号：EP03703358

申请日：2003-02-21

申请人： EISAI CO LTD

发明人： OHI NORIHITO ,  SATO NOBUAKI ,  KOHMURA NAOHIRO

IPC分类号： C07D231/56 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/55 ,  A61P1/08 ,  A61P9/10 ,  A61P13/02 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/36 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P39/00 ,  A61P43/00 ,  C07D231/54 ,  C07D401/12 ,  C07D405/12 ,  C07D487/06

CPC分类号： A61K31/55 ,  A61K31/416 ,  A61K31/4439 ,  C07D231/54 ,  C07D401/12 ,  C07D405/12 ,  C07D487/06

摘要： It is intended to provide novel fused ring indazole compounds having an excellent JNK inhibitory effect. More specifically, compounds represented by the following general formula, salts thereof or hydrates of the same are provided: (I) wherein Z11 and Z12 independently represent each carbonyl, methylene, etc.; ---- represents a double or single bond; R1a represents hydrogen, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered heteroaryl group; and R2a, R2b and R2c independently represent each (1) hydrogen, (2) halogeno, (3) nitro, etc.

公开(公告)号：EP1510516A4

公开(公告)日：2005-11-02

申请号：EP03733170

申请日：2003-05-29

申请人： EISAI CO LTD

发明人： OHI NORIHITO ,  SATO NOBUAKI ,  SOEJIMA MOTOHIRO ,  DOKO TAKASHI ,  TERAUCHI TARO ,  NAOE YOSHIMITSU ,  MOTOKI TAKAFUMI

IPC分类号： A61K31/407 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/43 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61P21/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  A61K31/415 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/08 ,  C07D519/00

CPC分类号： A61K31/506 ,  A61K31/407 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/43 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： A novel compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula or a salt thereof. (I) In the formula, R1 represents -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb, and Rc each independently represents hydrogen, halogeno, hydroxy, optionally substituted C1-6 alkyl, etc.); Cy means a 5- or 6-membered aromatic heterocycle; and V's each independently means -L-X-Y [wherein L means a single bond, optionally substituted C1-6 alkylene, etc.; X means a single bond, -A- (wherein A represents NR2, O, CO, S, SO, or SO2), etc.; and Y means hydrogen, halogeno, nitro, etc.].

公开(公告)号：EP1380576A4

公开(公告)日：2005-02-16

申请号：EP02724612

申请日：2002-04-15

申请人： EISAI CO LTD

发明人： OINUMA HITOSHI ,  OHI NORIHITO ,  SATO NOBUAKI ,  SOEJIMA MOTOHIRO ,  SESHIMO HIDENORI ,  TERAUCHI TARO ,  DOKO TAKASHI ,  KOHMURA NAOHIRO

IPC分类号： A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D231/56 ,  A61K31/416 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04

CPC分类号： C07D231/56

摘要： A novel 1H-indazole compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula (I), a salt thereof, or a hydrate of either: (I) wherein R means C6-14 aromatic cyclic hydrocarbon group; R , R , and R each independently means hydrogen, halogeno, cyano, etc.; L means a single bond, C1-6 alkylene, etc.; X means a single bond, a group represented by -CO-NH- or -NH-CO-, etc.; and Y means C3-8 cycloalkyl, a C6-14 aromatic cyclic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, etc.