公开(公告)号：EP1364952A4

公开(公告)日：2005-03-30

申请号：EP02711424

申请日：2002-02-08

申请人： EISAI CO LTD

发明人： HIBI SHIGEKI ,  TAKAHASHI YOSHINORI ,  HOSHINO YORIHISA ,  KIKUCHI KOICHI ,  SOEJIMA MOTOHIRO ,  YOSHIUCHI TATSUYA ,  SHIN KOGYOKU ,  ONO MUTSUKO ,  SHIBATA HISASHI ,  INO MITSUHIRO ,  HIRAKAWA TETSUYA

IPC分类号： A61P1/14 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P15/08 ,  A61P15/10 ,  A61P15/12 ,  A61P17/14 ,  A61P19/10 ,  A61P21/00 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/20 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P27/00 ,  A61P27/06 ,  A61P29/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/04 ,  A61P37/08 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377

CPC分类号： C07D471/04 ,  C07D487/04

摘要： A novel compound having an excellent antagonistic effect on a corticotropin-releasing-factor receptor. It is a compound represented by the following formula or a salt thereof. (I) In the formula, R1 represents hydrogen, C¿1-6? alkyl, C1-6 alkoxy, etc.; R?2¿ represents halogeno, cyano, nitro, C¿1-10? alkyl, C2-10 alkenyl, C2-10 alkynyl, etc.; R?3¿ represents an optionally substituted C¿6-14? aromatic hydrocarbon group or an optionally substituted, 5- to 14-membered aromatic heterocyclic group; and X, Y, and Z each independently represents nitrogen or CR?4¿ (wherein R4 represents hydrogen, halogeno, cyano, nitro, optionally halogenated C¿1-6? alkyl, etc.), provided that at least two of X, Y, and Z represent CR?4¿.

公开(公告)号：EP1238979A4

公开(公告)日：2003-01-15

申请号：EP00983479

申请日：2000-12-13

申请人： EISAI CO LTD

发明人： HIBI SHIGEKI ,  HOSHINO YORIHISA ,  YOSHIUCHI TATSUYA ,  SHIN KOGYOKU ,  KIKUCHI KOUICHI ,  SOEJIMA MOTOHIRO ,  TABATA MUTSUKO ,  TAKAHASHI YOSHINORI ,  SHIBATA HISASHI ,  HIDA TAKAYUKI ,  HIRAKAWA TETSUYA ,  INO MITSUHIRO

IPC分类号： A61P1/04 ,  A61P1/08 ,  A61P1/10 ,  A61P1/12 ,  A61P1/14 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  C07D471/14 ,  C07D487/14 ,  C07D491/14 ,  A61K31/437 ,  A61K31/519 ,  C07D473/02 ,  C07D495/14

CPC分类号： C07D471/14 ,  C07D487/14 ,  C07D491/14

摘要： Compounds represented by general formula (I) are provided, which exhibit antagonism against corticotropin-releasing factor receptor, wherein A, B and C are each independently -(CR1R2)m- (wherein R?1 and R2¿ are each C¿1-6? alkyl or the like, and m is an integer of 1 to 4), -NR?3¿- (wherein R3 is hydrogen or the like), or the like; E and G are each independently a heteroatom such as nitrogen, -(CR6R7)p- (wherein R?6 and R7¿ are each hydrogen or the like, and p is an integer of 0 to 2), or the like; J is a carbon atom substituted with aryl or the like, or a nitrogen atom; K and L are each independently carbon or nitrogen; M is hydrogen, optionally substituted alkyl, or the like; and the partial structures ----- are each a single or double bond.

公开(公告)号：EP1057830A4

公开(公告)日：2001-09-19

申请号：EP99906524

申请日：1999-02-26

申请人： EISAI CO LTD

发明人： YAMADA KOJI ,  MIYAMOTO MITSUAKI ,  YOSHIUCHI TATSUYA ,  SATO KEIZO ,  SOEJIMA MOTOHIRO ,  SATO TAKASHI ,  KIKUCHI KOICHI ,  YOSHIMURA HIROYUKI ,  MORIYA KATSUHIRO ,  SAKUMA YOSHINORI ,  AKASOFU SHIGERU

IPC分类号： C07D513/04 ,  A61K31/54 ,  A61K31/645

CPC分类号： C07D513/04

摘要： Heterocycle-fused benzothiazine derivatives represented by general formula (I) and salts thereof or hydrates of the same which are efficacious in preventing and treating diseases in which histamine, leukotriene, etc. participate, wherein the ring Het represents an unsaturated heterocycle; R?1 and R2¿ are the same or different and each represents halogeno, optionally substituted alkyl, alkoxy, cyano, etc.; D represents optionally substituted lower alkylene, etc.; Q represents amino, carboxy, a heterocycle, etc.; and x is an integer of 1 or 2.

公开(公告)号：EP1510516A4

公开(公告)日：2005-11-02

申请号：EP03733170

申请日：2003-05-29

申请人： EISAI CO LTD

发明人： OHI NORIHITO ,  SATO NOBUAKI ,  SOEJIMA MOTOHIRO ,  DOKO TAKASHI ,  TERAUCHI TARO ,  NAOE YOSHIMITSU ,  MOTOKI TAKAFUMI

IPC分类号： A61K31/407 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/43 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61P21/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  A61K31/415 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/08 ,  C07D519/00

CPC分类号： A61K31/506 ,  A61K31/407 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/43 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： A novel compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula or a salt thereof. (I) In the formula, R1 represents -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb, and Rc each independently represents hydrogen, halogeno, hydroxy, optionally substituted C1-6 alkyl, etc.); Cy means a 5- or 6-membered aromatic heterocycle; and V's each independently means -L-X-Y [wherein L means a single bond, optionally substituted C1-6 alkylene, etc.; X means a single bond, -A- (wherein A represents NR2, O, CO, S, SO, or SO2), etc.; and Y means hydrogen, halogeno, nitro, etc.].

公开(公告)号：EP1389618A4

公开(公告)日：2005-07-20

申请号：EP02720608

申请日：2002-04-25

申请人： EISAI CO LTD

发明人： HIBI SHIGEKI ,  KIKUCHI KOICHI ,  HOSHINO YORIHISA ,  SOEJIMA MOTOHIRO ,  YOSHIUCHI TATSUYA ,  SHIN KOGYOKU ,  ONO MUTSUKO ,  TAKAHASHI YOSHINORI ,  SHIBATA HISASHI ,  INO MITSUHIRO ,  HIRAKAWA TETSUYA

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P15/00 ,  A61P19/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P37/08 ,  A61P43/00 ,  C07D471/04 ,  C07F5/02 ,  C07F7/22 ,  A61K31/437 ,  A61K31/444

CPC分类号： C07D471/04 ,  A61K31/437 ,  C07F5/025 ,  C07F7/2212

摘要： Compounds represented by the general formula (I), salts thereof, and hydrates of both: (I) wherein R1 is methoxy, ethyl, methylthio, or the like; R?2, R3 and R4¿ are each hydrogen, halogeno, or the like; R?5 and R6¿ are each a group represented by the general formula: -X5-X6-X7 (wherein X5 is a single bond or CO-; X6 is a single bond, -NR3a-, or the like; X?7 and R3a¿ are each hydrogen, C¿1-10? alkyl, or the like); and Ar is phenyl, pyridyl, or the like.

公开(公告)号：EP1380576A4

公开(公告)日：2005-02-16

申请号：EP02724612

申请日：2002-04-15

申请人： EISAI CO LTD

发明人： OINUMA HITOSHI ,  OHI NORIHITO ,  SATO NOBUAKI ,  SOEJIMA MOTOHIRO ,  SESHIMO HIDENORI ,  TERAUCHI TARO ,  DOKO TAKASHI ,  KOHMURA NAOHIRO

IPC分类号： A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D231/56 ,  A61K31/416 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04

CPC分类号： C07D231/56

摘要： A novel 1H-indazole compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula (I), a salt thereof, or a hydrate of either: (I) wherein R means C6-14 aromatic cyclic hydrocarbon group; R , R , and R each independently means hydrogen, halogeno, cyano, etc.; L means a single bond, C1-6 alkylene, etc.; X means a single bond, a group represented by -CO-NH- or -NH-CO-, etc.; and Y means C3-8 cycloalkyl, a C6-14 aromatic cyclic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, etc.