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公开(公告)号：EP1140881A1
公开(公告)日：2001-10-10
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140903A1
公开(公告)日：2001-10-10
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140903B1
公开(公告)日：2004-08-04
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
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公开(公告)号：EP1349832A2
公开(公告)日：2003-10-08
申请号：EP01986459.4
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott , SMITH, Edward, C R
IPC分类号： C07D209/00 , A61K31/40 , A61P29/00
CPC分类号： C07D209/60
摘要： A novel class of benz[f]indole compounds see structure (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
摘要翻译： 公开了一类新型的苯并[f]吲哚化合物，参见结构（I），同时还公开了用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号：EP1311501A1
公开(公告)日：2003-05-21
申请号：EP01961622.6
申请日：2001-08-06
发明人： BEIGHT, Douglas, Wade , MASTERS, JOHN, Joseph , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D403/14 , A61K31/4015 , A61P7/02 , A61P9/10
CPC分类号： C07D401/14 , C07D403/12
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositionsthereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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6.发明公开
公开(公告)号：EP1181276A1
公开(公告)日：2002-02-27
申请号：EP00930084.9
申请日：2000-05-08
发明人： BEIGHT, Douglas, Wade , BUBEN, John, Andrew , MORIN, John, Michael, Junior , SALL, Daniel, Jon , SAWYER, Jason, Scott
IPC分类号： C07D209/22 , A61K31/535 , A61P29/00
CPC分类号： A61K31/5377 , C07D209/24 , Y02A50/401
摘要： The compound, ((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
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公开(公告)号：EP1019045A1
公开(公告)日：2000-07-19
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/16 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP0994712A1
公开(公告)日：2000-04-26
申请号：EP98933301.8
申请日：1998-07-08
发明人： JOHNSON, Douglas, Webb , MORIN, John, Michael, Jr. , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore
IPC分类号： A61K31/535 , A61K31/495 , A61K31/47 , A61K31/445 , A61K31/44 , A61K31/40 , A61K31/38 , A61K31/34 , A61K31/16 , A61K31/165
CPC分类号： A61K31/495 , A61K31/165 , A61K31/4045 , A61K31/4439 , A61K31/4453 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55
摘要： This invention provides methods for treating diseases and disorders associated with an excess of neutrophil mediated oxidant production.
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公开(公告)号：EP2491032A1
公开(公告)日：2012-08-29
申请号：EP10774072.2
申请日：2010-10-20
发明人： BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , EGGEN, MariJean , HENRY, Kenneth, James, Junior , JOHNS, Deidre, Michelle , PARTHASARATHY, Saravanan , PEI, Huaxing , REMPALA, Mark, Edward , SAWYER, Jason, Scott
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
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公开(公告)号：EP2155734A2
公开(公告)日：2010-02-24
申请号：EP08747731.1
申请日：2008-05-07
发明人： BROOKS, Harold, Burns , CRICH, Joyce, Z , HENRY, James, Robert , HU, Hong , JIANG, Delu , LI, Hong-yu , MCMILLEN, William, Thomas , SAWYER, Jason, Scott , SLATER, Melissa, Kate , WANG, Yan
IPC分类号： C07D409/14 , A61K31/506 , A61P35/00
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译： 本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。
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