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公开(公告)号：EP1140903A1
公开(公告)日：2001-10-10
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140881A1
公开(公告)日：2001-10-10
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1817287B1
公开(公告)日：2010-02-10
申请号：EP05851607.1
申请日：2005-11-10
发明人： ARGADE, Ankush, B., Rigel Pharmaceuticals, Inc. , GOODSON, Theodore, Junior , HERRON, David, Kent , JOSEPH, Sajan , LEPORE, Salvatore, Donato , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D211/46 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/12 , C07D295/18 , C07D409/14 , C07D413/12 , C07D333/38 , C07D409/06 , A61K31/4427 , A61P7/00 , A61K31/381 , A61K31/44 , C07C271/16
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
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公开(公告)号：EP1140903B1
公开(公告)日：2004-08-04
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
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公开(公告)号：EP1019045A1
公开(公告)日：2000-07-19
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/16 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1483265B1
公开(公告)日：2006-11-22
申请号：EP03711146.5
申请日：2003-03-04
发明人： CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin , SULLIVAN, John Morris , BERRIDGE, Brian Raymond , RUEGG, Charles Edward
IPC分类号： C07D487/06 , A61P25/08
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：EP1140905B1
公开(公告)日：2003-05-14
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , KYLE,Jeffrey , Wiley,Michael
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
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公开(公告)号：EP1140905A1
公开(公告)日：2001-10-10
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan, Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
摘要： This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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9.发明公开
公开(公告)号：EP1015479A1
公开(公告)日：2000-07-05
申请号：EP98914651.9
申请日：1998-04-08
发明人： MENDEL, David
IPC分类号： C07K5/12 , C07K7/50 , G01N33/53 , G01N33/566 , C12Q1/00
CPC分类号： C07D285/00 , C07B2200/11 , C07D513/04 , C07K1/047 , C07K14/001 , C40B40/04 , C40B50/14
摘要： The present invention relates to a novel diverse library of peptidomimetic macrocyclic compounds, processes for the preparation thereof, and to apparatus providing a readily accessible source of individual members of the library. The apparatus can be used in assay kits and as a replaceable element in automated assay machines.
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公开(公告)号：EP1819693B1
公开(公告)日：2009-08-26
申请号：EP05851697.2
申请日：2005-11-15
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/00 , C07D409/00 , C07D401/12 , C07D409/12 , C07D213/75 , C07D409/14 , C07C271/16 , C07C235/64 , A61K31/4465 , A61K31/4436 , A61P7/02
CPC分类号： C07D213/75 , C07C235/64 , C07C237/06 , C07C271/16 , C07C275/10 , C07C275/16 , C07C275/26 , C07C275/28 , C07C275/30 , C07D211/22 , C07D211/46 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/215 , C07D401/12 , C07D409/12 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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