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1.发明公开
公开(公告)号：EP1401806A1
公开(公告)日：2004-03-31
申请号：EP02729196.2
申请日：2002-05-24
Applicant: ELI LILLY AND COMPANY
Inventor： CORBETT, Thomas, Hughes , GROSSMAN, Cora, Sue , LOBB, Karen, Lynn , SHIH, Chuan , HIPSKIND, Philip, Arthur , LIN, Ho-Shen
IPC: C07C311/51 , C07C321/28 , C07D213/34 , C07D215/12 , C07D307/38 , C07D333/18 , C07D521/00 , A61K31/18 , A61K31/63 , A61P35/00
CPC classification number: C07D307/38 , A61K31/18 , C07C311/51 , C07C323/67 , C07D213/34 , C07D215/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/18
Abstract: The present invention provides antitumor compounds of the formula(I), and antitumor methods.
Abstract translation: 本发明提供了式（I）的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号：EP1720861A2
公开(公告)日：2006-11-15
申请号：EP05723430.4
申请日：2005-02-22
Applicant: ELI LILLY AND COMPANY
Inventor： BEAVERS, Lisa, Selsam , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , JESUDASON, Cynthia, Darshini , LINDSLEY, Craig, William , LOBB, Karen, Lynn , PICKARD, Richard, Todd
IPC: C07D403/00
CPC classification number: C07D295/125 , C07D207/09 , C07D295/02 , C07D295/096 , C07D295/155 , C07D295/192 , C07D487/04
Abstract: The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity and other histamine H3 receptor -related diseases.
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公开(公告)号：EP1003723A1
公开(公告)日：2000-05-31
申请号：EP98938395.5
申请日：1998-08-06
Applicant: ELI LILLY AND COMPANY
Inventor： FRITZ, James, Erwin , HIPSKIND, Philip, Arthur , KALDOR, Stephen, Warren , LOBB, Karen, Lynn , NIXON, James, Arthur
IPC: C07D215/16
CPC classification number: C07D401/12 , C07D209/14 , C07D413/12 , C07D417/12
Abstract: This invention provides a series of substituted propanamines useful as tachykinin receptor antagonists. This invention also provides methods employing these substituted propanamines as well as pharmaceutical formulations comprising these compounds.
Abstract translation: 本发明提供了一系列可用作速激肽受体拮抗剂的取代丙胺。 本发明还提供了使用这些取代的丙胺的方法以及包含这些化合物的药物制剂。
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4.发明授权BENZOYLSULFONAMIDES AND SULFONYLBENZAMIDINES FOR USE AS ANTITUMOUR AGENTS 有权BENZOYLSULFONAMIDE和SULFONYLBENZAMIDINE用作抗肿瘤药
公开(公告)号：EP1401806B1
公开(公告)日：2006-08-09
申请号：EP02729196.2
申请日：2002-05-24
Applicant: ELI LILLY AND COMPANY
Inventor： CORBETT, Thomas, Hughes , GROSSMAN, Cora, Sue , LOBB, Karen, Lynn , SHIH, Chuan , HIPSKIND, Philip, Arthur , LIN, Ho-Shen
IPC: C07C311/51 , C07C321/28 , C07D213/34 , C07D215/12 , C07D307/38 , C07D333/18 , C07D521/00 , A61K31/18 , A61K31/63 , A61P35/00
CPC classification number: C07D307/38 , A61K31/18 , C07C311/51 , C07C323/67 , C07D213/34 , C07D215/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/18
Abstract: The present invention provides antitumor compounds of the formula(I), and antitumor methods.
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公开(公告)号：EP1442030A1
公开(公告)日：2004-08-04
申请号：EP02802117.8
申请日：2002-10-15
Applicant: ELI LILLY AND COMPANY
Inventor： DE DIOS, Alfonso,Lilly, S. A. , GROSSMAN, Cora, Sue , HIPSKIND, Philip, Arthur , LIN, Ho-Shen , LOBB, Karen, Lynn , LOPEZ DE URALDE GARMENDIA, Beatriz,Lilly, S. A. , LOPEZ, Jose, Eduardo , MADER, Mary, Margaret , RICHETT, Michael, Enrico , SHIH, Chaun
IPC: C07D277/36 , C07D333/34 , A61K31/38 , A61K31/425 , A61P25/00
CPC classification number: C07D277/36 , C07D333/34 , C07D333/38
Abstract: The present invention provides antineoplastic compounds of the formula (I).
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Patent Agency Ranking
公开(公告)号：EP0729468A1
公开(公告)日：1996-09-04
申请号：EP95901928.0
申请日：1994-11-16
Applicant: ELI LILLY AND COMPANY
Inventor： CHO, Sung-Yong, Stephen , CROWELL, Thomas, Alan , GITTER, Bruce, Donald , HIPSKIND, Philip, Arthur , HOWBERT, James, Jeffry , KRUSHINSKI, Joseph, Herman, Jr. , LOBB, Karen, Lynn , MUEHL, Brian, Stephen , NIXON, James, Arthur
IPC: C07D295 , A61K31 , A61P1 , A61P9 , A61P11 , A61P13 , A61P17 , A61P19 , A61P25 , A61P29 , A61P43 , C07C211 , C07C217 , C07C233 , C07C271 , C07D209 , C07D211 , C07D223 , C07D233 , C07D333 , C07D401 , C07D403 , C07D409 , C07D413
CPC classification number: C07D401/12 , C07C233/44 , C07C233/78 , C07C271/20 , C07D209/14 , C07D209/16 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14
Abstract: This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.
Abstract translation: 本发明提供了一系列新的非肽基化合物，它们可用于治疗或预防与过量的速激肽有关的生理疾病。 本发明还提供了治疗这些生理疾病的方法以及使用这些新化合物的药物制剂。
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公开(公告)号：EP2358698A1
公开(公告)日：2011-08-24
申请号：EP09752059.7
申请日：2009-11-05
Applicant: Eli Lilly and Company
Inventor： BASTIAN, Jolie, Anne , CLAY, Julia, Marie , COHEN, Jeffrey, Daniel , HIPSKIND, Philip, Arthur , LOBB, Karen, Lynn , SALL, Daniel, Jon , WILSON (NEE TAKAKUWA), Takako , THOMPSON, Michelle, Lee
IPC: C07D401/04 , A61K31/501 , C07D401/14 , C07D417/14
CPC classification number: C07D401/04 , C07D401/14 , C07D417/14
Abstract: The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R
1 or N; R
1 is hydrogen, fluoro or cyano; R
2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R
3 is methyl or trifluoromethyl; R
4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R
5 is trifluoromethyl or methylsulfonyl; R
6 is hydrogen or methyl; and R
7 , R
8 , R
9 , R
10 and R
11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that al least two of R
7 , R
8 , R
9 , R
10 and R
11 are hydrogen useful in the treatment of cancer.-
公开(公告)号：EP1442030B1
公开(公告)日：2006-08-30
申请号：EP02802117.8
申请日：2002-10-15
Applicant: ELI LILLY AND COMPANY
Inventor： DE DIOS, Alfonso, Lilly, S. A. , GROSSMAN, Cora, Sue , HIPSKIND, Philip, Arthur , LIN, Ho-Shen , LOBB, Karen, Lynn , LOPEZ DE URALDE GARMENDIA, Beatriz, Lilly, S. A. , LOPEZ, Jose, Eduardo , MADER, Mary, Margaret , RICHETT, Michael, Enrico , SHIH, Chaun
IPC: C07D277/36 , C07D333/34 , A61K31/38 , A61K31/425 , A61P25/00
CPC classification number: C07D277/36 , C07D333/34 , C07D333/38
Abstract: The present invention provides antineoplastic compounds of the formula (I).
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9.发明公开NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES 审中-公开非咪唑阿魏酸亚苄基维生素ALS组胺素H3抗抑郁药，HERSTELLUNG UND PHARMAZEUTISCHE VERWENDUNGEN
公开(公告)号：EP1379493A2
公开(公告)日：2004-01-14
申请号：EP02723329.5
申请日：2002-03-21
Applicant: Eli Lilly and Company
Inventor： BEAVERS, Lisa, Selsam , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , LINDSLEY, Craig, William , LOBB, Karen, Lynn , NIXON, James, Arthur , PICKARD, Richard, Todd , SCHAUS, John, Mehnert , TAKAKUWA, Takako , WATSON, Brian, Morgan
IPC: C07C217/58 , A61K31/395 , A61K31/131 , A61P3/00 , A61P25/00 , C07D295/08 , C07D295/12 , C07C217/20 , C07C311/05 , C07C311/13 , C07C311/18 , C07C237/08 , C07D295/14 , C07C217/74 , C07C271/34 , C07C323/62 , C07C271/24 , C07C233/73 , C07C237/32 , C07C311/17 , C07C409/12
CPC classification number: C07D207/27 , C07B2200/07 , C07C217/20 , C07C217/58 , C07C217/74 , C07C233/73 , C07C237/08 , C07C237/32 , C07C271/24 , C07C271/34 , C07C311/05 , C07C311/09 , C07C311/11 , C07C311/18 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D207/09 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/26 , C07D213/38 , C07D215/20 , C07D217/06 , C07D217/08 , C07D217/24 , C07D231/04 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/14 , C07D241/44 , C07D243/08 , C07D249/08 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/15 , C07D307/12 , C07D307/14 , C07D307/46 , C07D333/34 , C07D401/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D487/04
Abstract: The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereofwhich have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat obesity and other histamine H3 receptor -related diseases.
Abstract translation: 本发明公开了具有选择性组胺-H 3受体拮抗剂活性的式（I）的新型取代芳基烷基胺化合物或其药学上可接受的盐以及其制备方法。 在另一个实施方案中，本发明公开了包含这种环胺的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法。
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公开(公告)号：EP2358698B1
公开(公告)日：2012-09-05
申请号：EP09752059.7
申请日：2009-11-05
Applicant: Eli Lilly and Company
Inventor： BASTIAN, Jolie, Anne , CLAY, Julia, Marie , COHEN, Jeffrey, Daniel , HIPSKIND, Philip, Arthur , LOBB, Karen, Lynn , SALL, Daniel, Jon , WILSON (NEE TAKAKUWA), Takako , THOMPSON, Michelle, Lee
IPC: C07D401/04 , A61K31/501 , C07D401/14 , C07D417/14
CPC classification number: C07D401/04 , C07D401/14 , C07D417/14
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