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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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2.发明公开COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE 有权化合物中，用于口服胰高血糖素样肽的方法和制剂（GLP）-1相关或黑皮质素4受体（MC4）AGONISTSCHEN肽
公开(公告)号：EP1658285A1
公开(公告)日：2006-05-24
申请号：EP04779447.4
申请日：2004-08-18
发明人： JUNGHEIM, Louis, Nickolaus , MCGILL, John, McNeill, III , THRASHER, Kenneth, Jeff , HERR, Robert, Jason , VALLURI, Muralikrishna
IPC分类号： C07D413/04 , A61K47/22
CPC分类号： C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
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公开(公告)号：EP1392702A1
公开(公告)日：2004-03-03
申请号：EP02728409.0
申请日：2002-03-28
IPC分类号： C07D498/14 , A61K31/435 , A61P35/00
CPC分类号： C07D498/14
摘要： The present invention relates to a compound of Formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1392701A1
公开(公告)日：2004-03-03
申请号：EP02723331.1
申请日：2002-03-27
发明人： COHEN, Jeffrey, Daniel , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , THRASHER, Kenneth, Jeff
IPC分类号： C07D498/14 , A61K31/435
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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5.发明授权COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE 有权化合物中，用于口服胰高血糖素样肽的方法和制剂（GLP）-1相关或黑皮质素4受体（MC4）AGONISTSCHEN肽
公开(公告)号：EP1658285B1
公开(公告)日：2007-05-02
申请号：EP04779447.4
申请日：2004-08-18
发明人： JUNGHEIM, Louis, Nickolaus , MCGILL, John, McNeill, III , THRASHER, Kenneth, Jeff , HERR, Robert, Jason , VALLURI, Muralikrishna
IPC分类号： C07D413/04 , A61K47/22
CPC分类号： C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
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6.发明授权COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE 有权化合物中，用于口服胰高血糖素样肽（GLP）的方法和制剂-1相关或AM黑皮质素4受体（MC4）的激动剂ACTING PEPTIDE
公开(公告)号：EP1658273B1
公开(公告)日：2007-01-03
申请号：EP04779446.6
申请日：2004-08-18
发明人： HERR, Robert, Jason , JUNGHEIM, Louis, Nickolaus , MCGILL, John, McNeill, III , THRASHER, Kenneth, Jeff , VALLURI, Muralikrishna
IPC分类号： C07D233/54 , C07D261/08 , C07D263/32 , C07D249/06 , C07D249/08 , C07D271/06 , C07D277/24 , C07D285/12 , A61K47/22
CPC分类号： C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
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公开(公告)号：EP1326851B1
公开(公告)日：2004-06-30
申请号：EP01979233.2
申请日：2001-10-09
发明人： DODGE, Jeffrey, Alan , EVERS, Britta , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , RUEHTER, Gerd , THRASHER, Kenneth, Jeff
IPC分类号： C07D275/06 , C07D417/12 , C07D275/02 , C07D209/54 , C07D207/38 , C07D409/04 , A61K31/425 , A61P5/06 , C07K5/06
CPC分类号： C07K5/06191 , A61K38/00 , C07K5/06026
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
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8.发明公开COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE 有权化合物中，用于口服胰高血糖素样肽（GLP）的方法和制剂-1相关或AM黑皮质素4受体（MC4）的激动剂ACTING PEPTIDE
公开(公告)号：EP1658273A1
公开(公告)日：2006-05-24
申请号：EP04779446.6
申请日：2004-08-18
发明人： HERR, Robert, Jason , JUNGHEIM, Louis, Nickolaus , MCGILL, John, McNeill, III , THRASHER, Kenneth, Jeff , VALLURI, Muralikrishna
IPC分类号： C07D233/54 , C07D261/08 , C07D263/32 , C07D249/06 , C07D249/08 , C07D271/06 , C07D277/24 , C07D285/12 , A61K47/22
CPC分类号： C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
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公开(公告)号：EP1638944A1
公开(公告)日：2006-03-29
申请号：EP04752574.6
申请日：2004-06-03
发明人： AMEGADZIE, Albert, Kudzovi , GARDINIER, Kevin, Matthew , HEMBRE, Erik, James , HIPSKIND, Philip, Arthur , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , SAVIN, Kenneth, Allen , THRASHER, Kenneth, Jeff , BOYD, Steven, A.
IPC分类号： C07D233/90 , C07D249/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/06 , C07D417/06
CPC分类号： C07D401/04 , C07D249/04 , C07D249/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/06 , C07D417/12 , C07D487/04
摘要： The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.
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公开(公告)号：EP1121125A1
公开(公告)日：2001-08-08
申请号：EP99954711.0
申请日：1999-10-01
CPC分类号： A61K31/381 , A61K31/38 , A61K31/40 , A61K31/445 , A61K2300/00
摘要： Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of structure (I) in combination with compounds of formula (II) where X, Y, R, R', R?6, R7, and R8¿ are as defined herein.
摘要翻译： 描述了使用结构式（I）化合物与式（II）化合物组合的式（II）化合物抑制与雌激素剥夺综合征相关的各种医学病症（包括骨质疏松症和高脂血症）的制剂和应用，其中X，Y，R，R' R 6，R 7和R 8如本文所定义。
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