公开(公告)号：EP1250340A1

公开(公告)日：2002-10-23

申请号：EP00986242.6

申请日：2000-12-11

申请人： ELI LILLY AND COMPANY ,  Wang, Qiuping

发明人： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC分类号： C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D471/04

摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).

公开(公告)号：EP1224189A2

公开(公告)日：2002-07-24

申请号：EP00968314.5

申请日：2000-09-22

申请人： ELI LILLY AND COMPANY

发明人： BONJOUKLIAN, Rosanne ,  JOHNSON, Douglas, Webb ,  LANDER, Peter, Ambrose ,  LOHMAN, Mark, Christopher ,  PATEL, Vinod, Francis ,  VEPACHEDU, Sreenivasarao ,  XIE, Yongping

IPC分类号： C07D498/04 ,  C07D471/04 ,  A61K31/4741 ,  A61K31/4745 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

公开(公告)号：EP1224189B1

公开(公告)日：2006-01-25

申请号：EP00968314.5

申请日：2000-09-22

申请人： ELI LILLY AND COMPANY

发明人： BONJOUKLIAN, Rosanne ,  JOHNSON, Douglas, Webb ,  LANDER, Peter, Ambrose ,  LOHMAN, Mark, Christopher ,  PATEL, Vinod, Francis ,  VEPACHEDU, Sreenivasarao ,  XIE, Yongping

IPC分类号： C07D498/04 ,  C07D471/04 ,  A61K31/4741 ,  A61K31/4745 ,  A61P35/00 ,  C07D261/00 ,  C07D221/00 ,  C07D231/00 ,  C07D263/00

CPC分类号： C07D471/04

摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

公开(公告)号：EP1250340B1

公开(公告)日：2004-11-17

申请号：EP00986242.6

申请日：2000-12-11

申请人： ELI LILLY AND COMPANY

发明人： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC分类号： C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D471/04

摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).