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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP1326851B1
公开(公告)日：2004-06-30
申请号：EP01979233.2
申请日：2001-10-09
发明人： DODGE, Jeffrey, Alan , EVERS, Britta , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , RUEHTER, Gerd , THRASHER, Kenneth, Jeff
IPC分类号： C07D275/06 , C07D417/12 , C07D275/02 , C07D209/54 , C07D207/38 , C07D409/04 , A61K31/425 , A61P5/06 , C07K5/06
CPC分类号： C07K5/06191 , A61K38/00 , C07K5/06026
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
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公开(公告)号：EP0729468A1
公开(公告)日：1996-09-04
申请号：EP95901928.0
申请日：1994-11-16
发明人： CHO, Sung-Yong, Stephen , CROWELL, Thomas, Alan , GITTER, Bruce, Donald , HIPSKIND, Philip, Arthur , HOWBERT, James, Jeffry , KRUSHINSKI, Joseph, Herman, Jr. , LOBB, Karen, Lynn , MUEHL, Brian, Stephen , NIXON, James, Arthur
IPC分类号： C07D295 , A61K31 , A61P1 , A61P9 , A61P11 , A61P13 , A61P17 , A61P19 , A61P25 , A61P29 , A61P43 , C07C211 , C07C217 , C07C233 , C07C271 , C07D209 , C07D211 , C07D223 , C07D233 , C07D333 , C07D401 , C07D403 , C07D409 , C07D413
CPC分类号： C07D401/12 , C07C233/44 , C07C233/78 , C07C271/20 , C07D209/14 , C07D209/16 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14
摘要： This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.
摘要翻译： 本发明提供了一系列新的非肽基化合物，它们可用于治疗或预防与过量的速激肽有关的生理疾病。 本发明还提供了治疗这些生理疾病的方法以及使用这些新化合物的药物制剂。
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公开(公告)号：EP1501809A1
公开(公告)日：2005-02-02
申请号：EP03723929.0
申请日：2003-04-22
发明人： AMEGADZIE, Albert, Kudzovi , GARDINIER, Kevin, Matthew , HEMBRE, Erik, James , HONG, Jian, Eric , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , REMICK, David, Michael , ROBERTSON, Michael, Alan , SAVIN, Kenneth, Allen
IPC分类号： C07D249/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/5025 , A61K31/505 , A61K31/5377
CPC分类号： C07D401/04 , C07D249/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04
摘要： This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents indpendently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)
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公开(公告)号：EP1392701A1
公开(公告)日：2004-03-03
申请号：EP02723331.1
申请日：2002-03-27
发明人： COHEN, Jeffrey, Daniel , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , THRASHER, Kenneth, Jeff
IPC分类号： C07D498/14 , A61K31/435
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1501809B1
公开(公告)日：2008-01-16
申请号：EP03723929.0
申请日：2003-04-22
发明人： AMEGADZIE, Albert, Kudzovi , GARDINIER, Kevin, Matthew , HEMBRE, Erik, James , HONG, Jian, Eric , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , REMICK, David, Michael , ROBERTSON, Michael, Alan , SAVIN, Kenneth, Allen
IPC分类号： C07D249/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/5025 , A61K31/505 , A61K31/5377
CPC分类号： C07D401/04 , C07D249/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04
摘要： This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents indpendently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)
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公开(公告)号：EP1638944A1
公开(公告)日：2006-03-29
申请号：EP04752574.6
申请日：2004-06-03
发明人： AMEGADZIE, Albert, Kudzovi , GARDINIER, Kevin, Matthew , HEMBRE, Erik, James , HIPSKIND, Philip, Arthur , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , SAVIN, Kenneth, Allen , THRASHER, Kenneth, Jeff , BOYD, Steven, A.
IPC分类号： C07D233/90 , C07D249/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/06 , C07D417/06
CPC分类号： C07D401/04 , C07D249/04 , C07D249/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/06 , C07D417/12 , C07D487/04
摘要： The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.
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公开(公告)号：EP1121125A1
公开(公告)日：2001-08-08
申请号：EP99954711.0
申请日：1999-10-01
CPC分类号： A61K31/381 , A61K31/38 , A61K31/40 , A61K31/445 , A61K2300/00
摘要： Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of structure (I) in combination with compounds of formula (II) where X, Y, R, R', R?6, R7, and R8¿ are as defined herein.
摘要翻译： 描述了使用结构式（I）化合物与式（II）化合物组合的式（II）化合物抑制与雌激素剥夺综合征相关的各种医学病症（包括骨质疏松症和高脂血症）的制剂和应用，其中X，Y，R，R' R 6，R 7和R 8如本文所定义。
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公开(公告)号：EP1501808A1
公开(公告)日：2005-02-02
申请号：EP03721561.3
申请日：2003-04-22
发明人： AMEGADZIE, Albert, Kudzovi , GARDINIER, Kevin, Matthew , HEMBRE, Erik, James , HONG, Jian, Eric , JUNGHEIM, Louis, Nickolaus , MUEHL, Brian, Stephen , REMICK, David, Michael , ROBERTSON, Michael, Alan , SAVIN, Kenneth, Allen
IPC分类号： C07D249/06 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D413/06 , C07D413/14 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4523 , A61K31/496 , A61K31/497 , A61K31/501
CPC分类号： C07D249/06 , C07D249/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/14
摘要： The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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