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公开(公告)号：EP3038641A2
公开(公告)日：2016-07-06
申请号：EP14789449.7
申请日：2014-10-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , SCHEUER, Werner , GEORGES, Guy
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。
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公开(公告)号：EP2809682B1
公开(公告)日：2020-04-08
申请号：EP13705405.2
申请日：2013-01-24
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公开(公告)号：EP3143048B1
公开(公告)日：2019-08-28
申请号：EP15721719.1
申请日：2015-05-12
发明人： BOSSENMAIER, Birgit , GERG, Michael , KRONER, Frank , NIEDERFELLNER, Gerhard , SCHRAEML, Michael , PEESS, Carmen , BUICK, Richard
IPC分类号： C07K16/32 , C07K16/34 , A61K39/395 , A61P35/00
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4.发明授权METHOD FOR THE SELECTION AND PRODUCTION OF TAILOR-MADE, SELECTIVE AND MULTI-SPECIFIC THERAPEUTIC MOLECULES COMPRISING AT LEAST TWO DIFFERENT TARGETING ENTITIES AND USES THEREOF 有权用于选择和生产包含至少两种不同靶向实体的定制产物，选择性和多特异性治疗性分子的方法及其用途
公开(公告)号：EP2867255B1
公开(公告)日：2017-07-19
申请号：EP13734693.8
申请日：2013-06-25
发明人： HEINDL, Dieter , HUELSMANN, Peter, Michael , KALUZA, Brigitte , KOPETZKI, Erhard , NIEDERFELLNER, Gerhard , TIEFENTHALER, Georg
IPC分类号： C07K16/00 , C07K16/46 , A61K39/395
CPC分类号： C07K16/00 , C07K16/32 , C07K16/468 , C12Q1/26 , C12Q1/58 , C12Q1/66 , G01N33/53 , G01N33/563
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公开(公告)号：EP3038641B1
公开(公告)日：2019-04-17
申请号：EP14789449.7
申请日：2014-10-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , GEORGES, Guy
IPC分类号： C07K14/21 , A61K38/00 , A61K39/395 , C07K16/30 , A61K47/68 , A61K38/16 , C07K16/12 , A61K39/00 , C07K16/40 , A61K31/337
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公开(公告)号：EP2655413B1
公开(公告)日：2019-01-16
申请号：EP11802941.2
申请日：2011-12-21
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公开(公告)号：EP3356417A1
公开(公告)日：2018-08-08
申请号：EP16775650.1
申请日：2016-09-29
发明人： BACAC, Marina , FAUTI, Tanja , FREIMOSER-GRUNDSCHOBER, Anne , IMHOF-JUNG, Sabine , KLEIN, Christian , KLOSTERMANN, Stefan , MOLHOJ, Michael , NIEDERFELLNER, Gerhard , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , UMAÑA, Pablo
CPC分类号： C07K16/28 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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8.发明授权
公开(公告)号：EP2917243B1
公开(公告)日：2018-03-14
申请号：EP13811131.5
申请日：2013-11-06
发明人： BOSSENMAIER, Birgit , CASAGOLDA VALLRIBERA, David , GEORGES, Guy , GERG, Michael , NIEDERFELLNER, Gerhard , SCHOLZ, Christian , SCHRAEML, Michael
IPC分类号： C07K16/32 , C07K14/195 , C07K14/705 , A61K47/68
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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公开(公告)号：EP3478722A1
公开(公告)日：2019-05-08
申请号：EP17742382.9
申请日：2017-06-30
发明人： KLEIN, Christian , SUSTMANN, Claudio , NIEDERFELLNER, Gerhard , GEIGER, Martina , ENDRES, Stefan , KOBOLD, Sebastian
IPC分类号： C07K16/28 , C07K16/30 , C07K14/71 , C12N5/0783 , A61P35/00
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10.发明授权ANTI-HER3/HER4 ANTIGEN BINDING PROTEINS BINDING TO THE BETA-HAIRPIN OF HER3 AND THE BETA-HAIRPIN OF HER4 有权抗-HER3 / HER4抗原结合蛋白与HER3的β发夹结合以及HER4的β半乳糖苷酶
公开(公告)号：EP2917242B1
公开(公告)日：2018-05-16
申请号：EP13789759.1
申请日：2013-11-06
发明人： BOSSENMAIER, Birgit , GEORGES, Guy , GERG, Michael , NIEDERFELLNER, Gerhard , SCHOLZ, Christian , SCHRAEML, Michael
IPC分类号： C07K16/32 , A61K39/395 , A61P35/00 , A61K39/00
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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