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公开(公告)号：EP1957510A1
公开(公告)日：2008-08-20
申请号：EP06819838.1
申请日：2006-11-29
发明人： CHUN, Byoung-Kwon , CLARK, Jeremy , SARMA, Keshab , WANG, Peiyuan
IPC分类号： C07H19/06 , A61K31/7068 , A61P31/14
摘要： Compounds having the formula I wherein R1 is as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, and processes for making the compounds of formula I.
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公开(公告)号：EP2376088A2
公开(公告)日：2011-10-19
申请号：EP09795670.0
申请日：2009-12-23
申请人： Pharmasset, Inc.
IPC分类号： A61K31/7076
CPC分类号： C07H19/20
摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。
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3.发明公开PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 有权烷基取代的2-脱氧-2- FLUOR-D RIBOFURANOSYLPYRIMIDINEN及其衍生物-PURINEN的生产
公开(公告)号：EP1773856A2
公开(公告)日：2007-04-18
申请号：EP05775359.2
申请日：2005-07-21
申请人： Pharmasset, Inc.
发明人： WANG, Peiyuan , CHUN, Byoung-Kwon , SHI, Junxing , DU, Jinfa , STEC, Wojciech, Kolonia Wola Zaradzynski
CPC分类号： C07H19/173 , C07H19/073
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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4.发明公开COMPOUNDS WITH THE BICYCLO 4.2.1 NONANE SYSTEM FOR THE TREATMENT OF i FLAVIVIRIDAE /i INFECTIONS 审中-公开WITH THE二环4.2.1壬烷SYSTEM LINKS用于治疗黄病毒科我/ 1感染
公开(公告)号：EP1545545A2
公开(公告)日：2005-06-29
申请号：EP03767138.5
申请日：2003-08-01
申请人： Pharmasset, Inc.
发明人： WANG, Peiyuan , STUYVER, Lieven, J. , WATANABE, Kyoichi, A. , HASSAN, Abdalla , CHUN, Byoung-Known , HOLLECKER, Laurent
IPC分类号： A61K31/55 , A61P31/00 , C07D243/00 , C07D273/00
CPC分类号： C07H19/167 , A61K31/513 , A61K31/553 , A61K31/58 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K38/2066 , A61K38/21 , C07D487/16 , C07D498/22 , C07H9/06 , A61K2300/00
摘要： The disclosed invention is a bicyclo[4.2.1]nonane and its pharmaceutically acceptable salt or prodrug, and its composition and method of use to treat Flaviviridae (Hepacivirus, Flavivirus, and Pestivirus) infections on a host, including animals, and especially humans.
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5.发明公开N- [ (2 ' R) -2 ' -DEOXY-2 ' -FLUORO-2 ' -METHYL-P-PHENYL-5 ' -URIDYLYL]-L-ALANINE 1-METHYLETHYL ESTER AND PROCESS FOR ITS PRODUCTION 有权N个制造方法 - [（2'R）-2'-脱氧-2'-氟-2'-甲基 - 对 - 苯基-5“-URIDYLYL] -L-丙氨酸1-甲基乙基酯
公开(公告)号：EP2432792A1
公开(公告)日：2012-03-28
申请号：EP10721225.0
申请日：2010-05-20
申请人： Pharmasset, Inc.
发明人： ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , RACHAKONDA, Suguna , ZHANG, Hai-ren , CHUN, Byoung-kwon , WANG, Peiyuan
IPC分类号： C07H19/10 , C07H19/073 , A61K31/7072 , A61P31/14
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates of formula 4 and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
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6.发明授权PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 有权烷基取代的2-脱氧-2- FLUOR-D RIBOFURANOSYLPYRIMIDINEN及其衍生物-PURINEN的生产
公开(公告)号：EP1773856B1
公开(公告)日：2012-02-01
申请号：EP05775359.2
申请日：2005-07-21
申请人： Pharmasset, Inc.
发明人： WANG, Peiyuan , CHUN, Byoung-Kwon , SHI, Junxing , DU, Jinfa , STEC, Wojciech, Kolonia Wola Zaradzynski , CLARK, Jeremy
IPC分类号： C07B37/00
CPC分类号： C07H19/173 , C07H19/073
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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公开(公告)号：EP2203462A2
公开(公告)日：2010-07-07
申请号：EP08732818.3
申请日：2008-03-26
申请人： Pharmasset, Inc.
IPC分类号： C07H19/10 , C07H19/20 , C07H19/04 , C07H19/06 , A61K31/7064 , A61K31/7076 , A61K31/706 , A61P31/14
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing the compounds represented by formula I.
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8.发明公开PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 审中-公开制造'氟代-2'-烷基取代或以其他方式可选取代核糖基嘧啶和嘌呤及其衍生物
公开(公告)号：EP1809301A2
公开(公告)日：2007-07-25
申请号：EP05808357.7
申请日：2005-09-13
申请人： Pharmasset, Inc.
IPC分类号： A61K31/7072
摘要： The present invention provides (i) processes for preparing a 2'-deoxy-2'fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methyl-ss-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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