REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR
    1.
    发明公开
    REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR 有权
    REPLIKATIONSDEFIZIENTER ADENOVIRALER TNF VEKTOR

    公开(公告)号:EP1294918A2

    公开(公告)日:2003-03-26

    申请号:EP01950575.9

    申请日:2001-06-27

    申请人: GENVEC, INC.

    摘要: An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.

    ADENOVIRAL VECTOR-BASED VACCINES
    3.
    发明公开
    ADENOVIRAL VECTOR-BASED VACCINES 有权
    腺病毒载体,为基础的疫苗

    公开(公告)号:EP1649028A2

    公开(公告)日:2006-04-26

    申请号:EP04779179.3

    申请日:2004-07-26

    申请人: GENVEC, INC.

    IPC分类号: C12N15/861 A61K39/235

    摘要: The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80 % or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

    REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR
    4.
    发明授权
    REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR 有权
    复制缺陷的腺病毒TNF载体

    公开(公告)号:EP1294918B1

    公开(公告)日:2005-10-12

    申请号:EP01950575.9

    申请日:2001-06-27

    申请人: GenVec, Inc.

    摘要: An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.