公开(公告)号：EP1210418B1

公开(公告)日：2010-08-18

申请号：EP00916675.2

申请日：2000-03-30

申请人： Genentech, Inc.

发明人： ASHKENAZI, Avi, J ,  BAKER, Kevin P. ,  BOTSTEIN, David ,  DESNOYERS, Luc ,  EATON, Dan,L. ,  FERRARA, Napoleone ,  GERBER, Hanspeter ,  GERRITSEN, Mary,E ,  GODDARD, Audrey ,  GODOWSKI, PaulJ. ,  GRIMALDI, Christipher, J ,  GURNEY, Austin, L. ,  KLJAVIN, Ivar,J. ,  NAPIER,Mary, A ,  PAN, James ,  PAONI, Nicholas F. ,  ROY, Margaret,Ann ,  STEWART, Timothy, A ,  TUMAS, Daniel ,  WATANABE, Colin, K ,  WILLIAMS, P.,Mickey ,  WOOD, William, I ,  ZHANG, Zemin ,  FONG, Sherman

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/705 ,  C12N15/62 ,  C07K16/18 ,  G01N33/53 ,  A61K38/17 ,  A61K31/7088

CPC分类号： A61K38/17 ,  C07K14/005 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N2710/16222

公开(公告)号：EP1169448B1

公开(公告)日：2013-05-08

申请号：EP00923254.7

申请日：2000-04-12

申请人： Genentech, Inc.

发明人： GODDARD, Audrey ,  PAN, James ,  YAN, Minhong

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K16/28 ,  A61K38/17

CPC分类号： C12N15/10 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/4705 ,  C07K14/70578 ,  C12N2799/026 ,  C12Q1/686 ,  C12Q2531/113 ,  C12Q2521/331

公开(公告)号：EP1135496B1

公开(公告)日：2010-12-22

申请号：EP99973036.9

申请日：1999-11-03

申请人： Genentech, Inc.

发明人： ADAMS, Sean ,  PAN, James

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N5/10 ,  C12N1/19 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  A61K38/17 ,  G01N33/53

CPC分类号： C07K14/47 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

公开(公告)号：EP1309685A2

公开(公告)日：2003-05-14

申请号：EP01951036.1

申请日：2001-07-09

申请人： Genentech, Inc. ,  Baker, Kevin P. ,  Ferrara, Napoleone ,  Gerber, Hanspeter ,  Gerritsen, Mary E. ,  Goddard, Audrey ,  Godowski, Paul J. ,  Gurney, Austin L. ,  Hillan, Kenneth J. ,  Marsters, Scot A. ,  Pan, James ,  Paoni, Nicholas F. ,  Stephan, Jean-Philippe F. ,  Watanabe, Colin K. ,  Williams, P. Mickey ,  Wood, William I.

发明人： BAKER, Kevin, P. ,  FERRARA, Napoleone ,  GERBER, Hanspeter ,  GERRITSEN, Mary, E. ,  GODDARD, Audrey ,  GODOWSKI, Paul, J. ,  GURNEY, Austin, L. ,  HILLAN, Kenneth, J. ,  MARSTERS, Scot, A. ,  PAN, James ,  PAONI, Nicholas, F. ,  STEPHAN, Jean-Philippe, F. ,  WATANABE, Colin, K. ,  WILLIAMS, P., Mickey ,  WOOD, William, I. ,  YE, Weilan

IPC分类号： C12N15/12 ,  C07K14/475 ,  C07K16/22 ,  A61K38/00

CPC分类号： C07K14/515

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1263948A2

公开(公告)日：2002-12-11

申请号：EP00907314.9

申请日：2000-02-18

申请人： Genentech, Inc.

发明人： ASZKENAZI, Avi J. ,  BAKER, Kevin P. ,  BOTSTEIN, David ,  DESNOYERS, Luc ,  EATON, Dan L. ,  FERRARA, Napoleone ,  FILVAROFF, Ellen ,  FONG, Sherman ,  GAO, Wei-Qiang ,  GERBER, Hanspeter ,  GERRITSEN, Mary E. ,  GODDARD, Audrey ,  GODOWSKI, Paul J. ,  GRIMALDI, Christopher G. ,  GURNEY, Austin L. ,  HILLAN, Kenneth J. ,  KLJAVIN, Ivar J. ,  KUO, Sophia S. ,  NAPIER, Mary A. ,  PAN, James ,  PAONI, Nicholas F. ,  ROY, Margaret Ann ,  SHELTON, David L. ,  STEWART, Timothy A. ,  TUMAS, Daniel ,  WILLIAMS, P. Mickey ,  WOOD, William I.

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C07K14/47 ,  C07K14/705 ,  C07K19/00 ,  C07K16/18 ,  C07K16/28 ,  G01N33/68 ,  G01N33/543 ,  A61K47/48 ,  A61K51/08 ,  A61K38/17

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C12N2799/026 ,  C12N2799/027

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：EP1135496A2

公开(公告)日：2001-09-26

申请号：EP99973036.9

申请日：1999-11-03

申请人： Genentech, Inc.

发明人： ADAMS, Sean ,  PAN, James

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N5/10 ,  C12N1/19 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  A61K38/17 ,  G01N33/53

CPC分类号： C07K14/47 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCPs”）具有同源性的新多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。

公开(公告)号：EP1169442B1

公开(公告)日：2006-06-07

申请号：EP00917717.1

申请日：2000-03-01

申请人： GENENTECH, INC.

发明人： DESNOYERS, Luc ,  EATON, Dan, L. ,  GODDARD, Audrey ,  GODOWSKI, Paul, J. ,  GURNEY, Austin, L. ,  PAN, James ,  STEWART, Timothy, A. ,  WATANABE, Colin, K. ,  WOOD, William, I. ,  ZHANG, Zemin

IPC分类号： C12N15/12 ,  C12N15/52 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/40

CPC分类号： C07K14/70578 ,  C07K14/47 ,  C07K2319/00

公开(公告)号：EP1402260A2

公开(公告)日：2004-03-31

申请号：EP02731246.1

申请日：2002-04-03

申请人： Genentech, Inc.

发明人： GODDARD, Audrey ,  PAN, James ,  WOOD, William, I.

IPC分类号： G01N33/53 ,  C12N15/00 ,  C12N5/00 ,  C07K14/00 ,  C07K16/46 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K14/47 ,  G01N33/6893 ,  G01N2800/02

摘要： The present invention is directed to novel polypeptides NS4 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating body weight disorders (e.g, obesity, cachexia or anorexia) are provided.

公开(公告)号：EP1210418A1

公开(公告)日：2002-06-05

申请号：EP00916675.2

申请日：2000-03-30

申请人： Genentech Inc.

发明人： ASHKENAZI, Avi, J ,  BAKER, Kevin P. ,  BOTSTEIN, David ,  DESNOYERS, Luc ,  EATON, Dan,L. ,  FERRARA, Napoleone ,  GERBER, Hanspeter ,  GERRITSEN, Mary,E ,  GODDARD, Audrey ,  GODOWSKI, PaulJ. ,  GRIMALDI, Christipher, J ,  GURNEY, Austin, L. ,  KLJAVIN, Ivar,J. ,  NAPIER,Mary, A ,  PAN, James ,  PAONI, Nicholas F. ,  ROY, Margaret,Ann ,  STEWART, Timothy, A ,  TUMAS, Daniel ,  WATANABE, Colin, K ,  WILLIAMS, P.,Mickey ,  WOOD, William, I ,  ZHANG, Zemin

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/05 ,  C12N15/62 ,  C07K16/18 ,  G01N33/53 ,  A61K38/17

CPC分类号： A61K38/17 ,  C07K14/005 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N2710/16222

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1141285A2

公开(公告)日：2001-10-10

申请号：EP99962992.6

申请日：1999-12-01

申请人： Genentech, Inc.

发明人： BOTSTEIN, David ,  DESNOYERS, Luc ,  FERRARA, Napoleone ,  FONG, Sherman ,  GAO, Wei-Qiang ,  GODDARD, Audrey ,  GURNEY, Austin, L. ,  PAN, James ,  ROY, Margaret, Ann ,  STEWART, Timothy, A. ,  TUMAS, Daniel ,  WATANABE, Colin, K. ,  WOOD, William, I.

IPC分类号： C12N15/12 ,  C12N9/02 ,  C07K14/47 ,  C07K14/705 ,  C12N15/62 ,  C07K16/18

CPC分类号： C12N9/001 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.