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1.发明授权TISSUE PLASMINOGEN ACTIVATOR HAVING ZYMOGENIC OR FIBRIN SPECIFIC PROPERTIES 失效组织型纤溶酶原激活剂或属性的纤维蛋白酶原。
公开(公告)号：EP0457758B1
公开(公告)日：1995-06-28
申请号：EP89909997.2
申请日：1989-08-29
申请人： GENENTECH, INC.
发明人： ANDERSON, Stephen , BENNETT, William, F. , BOTSTEIN, David , HIGGINS, Deborah, L. , PAONI, Nicholas, F. , ZOLLER, Mark
CPC分类号： C12N9/6456 , A61K38/00
摘要： Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation of reformation in mammals.
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2.发明公开TISSUE PLASMINOGEN ACTIVATOR GLYCOSYLATION VARIANTS WITH IMPROVED THERAPEUTIC PROPERTIES 失效组织纤溶酶原具有改善治疗效果的偏差。
公开(公告)号：EP0643772A1
公开(公告)日：1995-03-22
申请号：EP93914240.0
申请日：1993-05-28
申请人： GENENTECH, INC.
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
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公开(公告)号：EP0830143B1
公开(公告)日：2003-03-05
申请号：EP96913814.8
申请日：1996-04-17
申请人： GENENTECH, INC.
发明人： FERRARA, Napoleone , KING, Kathleen , LUIS, Elizabeth, A. , MATHER, Jennie, P. , PAONI, Nicholas, F.
IPC分类号： A61K39/395 , A61K38/17 , C12N5/12 , C07K4/12
CPC分类号： C07K16/244 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K38/08 , A61K2300/00
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
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4.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和诊断方法和治疗疾病的为其血管生成的作用
公开(公告)号：EP1309620A2
公开(公告)日：2003-05-14
申请号：EP01957073.8
申请日：2001-06-20
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
CPC分类号： C07K14/47
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1212417A2
公开(公告)日：2002-06-12
申请号：EP00939307.5
申请日：2000-05-17
申请人： Genentech Inc.
发明人： ASKENAZI, Avi J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KUO, Sophia, S. , MARK, Malanie, R. , MARSTERS, Scot, A. , PAONI, Nicholas, F. , PITTI, Robert, M. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , C07K14/52 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/11 , C12N15/86
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/475 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP0618964A1
公开(公告)日：1994-10-12
申请号：EP93901389.0
申请日：1992-12-14
申请人： GENENTECH, INC.
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： L'invention concerne des variantes bioactives d'activateurs tissulaires du plasminogène. L'invention concerne notamment des variantes en position 276 présentant une spécificité accrue vis-à-vis de la fibrine.
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7.发明授权PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485B1
公开(公告)日：2010-02-17
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
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8.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和方法血管生成相关的疾病的诊断和治疗
公开(公告)号：EP1309685A2
公开(公告)日：2003-05-14
申请号：EP01951036.1
申请日：2001-07-09
申请人： Genentech, Inc. , Baker, Kevin P. , Ferrara, Napoleone , Gerber, Hanspeter , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth J. , Marsters, Scot A. , Pan, James , Paoni, Nicholas F. , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Williams, P. Mickey , Wood, William I.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
IPC分类号： C12N15/12 , C07K14/475 , C07K16/22 , A61K38/00
CPC分类号： C07K14/515
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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9.发明授权THE COMBINATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR, FOR TREATING CONGESTIVE HEART FAILURE 失效生长激素和胰岛素样生长因子 - 我可用于治疗充血性心脏衰竭的组合
公开(公告)号：EP0755265B1
公开(公告)日：2001-11-07
申请号：EP95914882.6
申请日：1995-03-30
申请人： GENENTECH, INC.
CPC分类号： A61K38/30 , A61K38/27 , A61K2300/00
摘要： Methods of enhancing myocardial contractility and cardiac performance in a mammal with congestive heart failure are disclosed. In a first method a mammal with congestive heart failure is treated by administering to the mammal an effective amount of a combination of growth hormone (GH) and insulin-like growth factor (IGF-I). A second method comprises administering to the mammal an effective amount of a combination of GH and IGF-I in the presence of an ACE inhibitor. This method results in enhancement of myocardial contractility and cardiac performance above the level achieved with ACE inhibition alone. Preferably the mammal is a human.
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10.发明公开PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485A2
公开(公告)日：2001-09-26
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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