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公开(公告)号：EP1463751A4
公开(公告)日：2005-03-23
申请号：EP02799966
申请日：2002-12-23
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P3/10 , A61P7/06 , A61P13/12 , A61P19/06 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/76 , C07K14/765 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/04 , C07K1/00 , A01N37/18 , C12N15/62 , C12P21/06 , G01N31/00
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
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公开(公告)号：EP1274720A4
公开(公告)日：2004-08-18
申请号：EP01932549
申请日：2001-04-12
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C07K1/00
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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公开(公告)号：EP2211888A4
公开(公告)日：2010-11-17
申请号：EP08843705
申请日：2008-10-30
发明人： ROSEN CRAIG A , BELL ADAM , MOORE PAUL A , SHI YANGGU , LAFLEUR DAVID , BOCK JASON B , LAIRD MICHAEL W , HASELTINE WILLIAM A , WOODS DOUGLAS B , SUBRAMANIAN MANI
CPC分类号： C07K14/58 , C07K14/765 , C07K2319/01
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公开(公告)号：EP1499353A4
公开(公告)日：2006-04-05
申请号：EP03728362
申请日：2003-04-10
发明人： ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： A61K39/395 , A61K31/7088 , A61K47/48 , A61K51/10 , A61P35/00 , A61P37/00 , C07K16/28 , C12N1/21 , C12N5/24 , C12N15/13 , C12N15/70 , C12Q1/68 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding antiTL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.
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5.发明公开NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPONGE VARIANT
公开(公告)号：EP1507793A4
公开(公告)日：2006-02-01
申请号：EP02786413
申请日：2002-10-16
发明人： YU GUO-LIANG , EBNER REINHARD , NI JIAN , ROSEN CRAIG A , LAIRD MICHAEL W , ULLRICH STEPHEN
CPC分类号： A61K51/08 , A61K38/00 , C07K14/525
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公开(公告)号：EP1228082A4
公开(公告)日：2005-11-16
申请号：EP00947553
申请日：2000-07-20
发明人： ROSEN CRAIG A , RUBEN STEVEN M , EBNER REINHARD , DUAN ROXANNE D , NI JIAN , SOPPET DANIEL R , MOORE PAUL A , SHI YANG-GU , LAFLEUR DAVID W , OLSEN HENRIK S , BIRSE CHARLES E , KOMATSOULIS GEORGES A
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K5/04 , C07K16/00
CPC分类号： C07H21/04 , C07K14/47 , C07K16/18 , C07K2317/622 , C07K2319/30
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公开(公告)号：EP1370651A4
公开(公告)日：2005-04-06
申请号：EP02714961
申请日：2002-02-21
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE , BAKER KEVIN P , FISCELLA MICHELE , MOORE PAUL A , WEI PING , DUAN D ROXANNE , SHI YANGGU , GUPTA RAM
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68 , C12N15/00 , A61K38/00 , C07K14/705 , C07K16/18 , C12N5/10 , G01N33/50
CPC分类号： C07K14/47
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公开(公告)号：EP1062236A4
公开(公告)日：2005-03-23
申请号：EP99911423
申请日：1999-03-11
发明人： RUBEN STEVEN M , FERRIE ANN M , ROSEN CRAIG A , FLORENCE CHARLES , YOUNG PAUL E , YU GUO-LIANG , NI JIAN
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P1/04 , A61P7/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C07K14/435 , C12N5/00 , C12N15/12 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
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公开(公告)号：EP1313761A4
公开(公告)日：2005-01-26
申请号：EP01904899
申请日：2001-01-17
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K48/00
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公开(公告)号：EP1325020A4
公开(公告)日：2004-12-15
申请号：EP01910321
申请日：2001-01-09
发明人： KOMATSOULIS GEORGE A , BAKER KEVIN P , ROSEN CRAIG A , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , NI JIAN , FISCELLA MICHELE , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H
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