公开(公告)号：EP1472285A2

公开(公告)日：2004-11-03

申请号：EP02720804.0

申请日：2002-01-15

申请人： Incyte Genomics, Inc.

发明人： PANZER, Scott, R. ,  LINCOLN, Stephen, E. ,  ALTUS, Christina, M. ,  DUFOUR, Gerard, E. ,  JACKSON, Jennifer, L. ,  JONES, Anissa, Lee ,  DAM, Tam, C. ,  LIU, Tommy, F. ,  HARRIS, Bernard ,  FLORES, Vincent ,  DAFFO, Abel ,  MARWAHA, Rakesh ,  CHEN, Alice, J. ,  CHANG, Simon, C. ,  GERSTIN, Edward, H., Jr. ,  PERALTA, Careyna, H. ,  DAVID, Marie, H. ,  LEWIS, Samantha, A.

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/50 ,  C12N15/12 ,  C12Q1/68 ,  C12N5/10 ,  A01K67/027

CPC分类号： C07K16/18 ,  A01K2217/05 ,  C07K14/47

摘要： The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

公开(公告)号：EP1356032A2

公开(公告)日：2003-10-29

申请号：EP01955908.7

申请日：2001-07-20

申请人： Incyte Genomics, Inc. ,  Thornton, Michael

发明人： YUE, Henry ,  KHAN, Farrah, A. ,  GURURAJAN, Rajagopal ,  HAFALIA, April, J., A. ,  CHAWLA, Narinder K. ,  ARVIZU, Chandra S. ,  RAMKUMAR, Jayalaxmi ,  GANDHI, Ameena, R. ,  POLICKY, Jennifer, L. ,  BAUGHN, Mariah, R. ,  TRIBOULEY, Catherine, M. ,  BANDMAN, Olga ,  NGUYEN, Danniel, B. ,  LU, Yan ,  BURFORD, Neil ,  LAL, Preeti ,  DING, Li ,  YAO, Monique, G. ,  ELLIOTT, Vicki, S. ,  RECIPON, Shirley, A. ,  KEARNEY, Liam ,  LU, Dyung, Aina, M. ,  GREENWALD, Sara, R. ,  TANG, Y., Tom ,  XU, Yuming ,  WALSH, Roderick, T. ,  GIETZEN, Kimberly, J. ,  YANG, Junming ,  JACKSON, Jennifer, L. ,  THORNTON, Michael

IPC分类号： C12N15/00 ,  C12N15/54 ,  C07K16/40 ,  C12N15/63 ,  C12N9/12 ,  A61K38/45 ,  C12Q1/48 ,  C12Q1/68

CPC分类号： C12N9/1205

摘要： The invention provides human human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associatedd withd abberant expression of PKIN.

摘要翻译： 本发明提供了鉴定和编码PKIN的人类人类激酶（PKIN）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与PKIN异常表达相关的疾病的方法。

公开(公告)号：EP1349935A2

公开(公告)日：2003-10-08

申请号：EP02709031.5

申请日：2002-01-09

申请人： Incyte Genomics, Inc.

发明人： PANZER, Scott, R. ,  LINCOLN, Stephen, E. ,  ALTUS, Christina, M. ,  DUFOUR, Gerard, E. ,  JACKSON, Jennifer, L. ,  JONES, Anissa, L. ,  DAM, Tam, C. ,  LIU, Tommy, F. ,  HARRIS, Bernard ,  FLORES, Vincent ,  DAFFO, Abel ,  MARWAHA, Rakesh ,  CHEN, Alice, J. ,  CHANG, Simon, C. ,  GERSTIN, Edward, H., Jr. ,  PERALTA, Careyna, H. ,  DAVID, Marie, H. ,  LEWIS, Samantha, A.

IPC分类号： C12N15/12 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  G01N33/50

CPC分类号： C07K16/18 ,  A01K2217/05 ,  C07K14/47

摘要： The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

公开(公告)号：EP1521824A2

公开(公告)日：2005-04-13

申请号：EP02728471.0

申请日：2002-03-14

申请人： Incyte Genomics, Inc.

发明人： JACKSON, Jennifer, L. ,  BAUGHN, Mariah, R. ,  SWARNAKAR, Anita ,  YUE, Henry ,  ELLIOTT, Vicki, S. ,  BURFORD, Neil ,  DING, Li ,  TANG, Y., Tom ,  LEE, Soo, Yeun ,  AZIMZAI, Yalda ,  CHAWLA, Narinder, K. ,  GIETZEN, Kimberly, J. ,  GRIFFIN, Jennifer, A. ,  LAL, Preeti, G. ,  YANG, Junming ,  BOROWSKY, Mark, L. ,  RICHARDSON, Thomas, W. ,  YUE, Huibin ,  BECHA, Shanya ,  FORSYTHE, Ian J. ,  JONES, Karen Anne ,  WARREN, Bridget A. ,  THANGAVELU, Kavitha ,  HONCHELL, Cynthia D. ,  JOLLEY, Helen E. ,  HAFALIA, April J.A. ,  RING, Huijun Z.

IPC分类号： C12N9/10 ,  C12N15/54 ,  C12N15/70 ,  C12N15/79 ,  A61K38/45

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00

摘要： The invention provides human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.

公开(公告)号：EP1265918A1

公开(公告)日：2002-12-18

申请号：EP01918776.4

申请日：2001-03-15

申请人： Incyte Genomics, Inc.

发明人： TANG, Y., Tom ,  JACKSON, Jennifer, L. ,  BAUGHN, Mariah, R. ,  Yue , Henry

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N5/10 ,  C12Q1/68 ,  A01K67/027 ,  C07K16/18 ,  A61K38/17 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The invention provides human immune response proteins (HIRP) and polynucleotides which identify and encode HIRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of HIRP.

公开(公告)号：EP1497319A2

公开(公告)日：2005-01-19

申请号：EP02766901.9

申请日：2002-05-01

申请人： Incyte Genomics, Inc.

发明人： YUE, Henry ,  LEE, Ernestine, A. ,  DUGGAN, Brendan, M. ,  THANGAVELU, Kavitha ,  HONCHELL, Cynthia, D. ,  DING, Li ,  JACKSON, Jennifer, L. ,  BAUGHN, Mariah, R. ,  KALLICK, Deborah, A. ,  LEE, Sally ,  WARREN, Bridget, A. ,  XU, Yuming ,  TRAN, Uyen, K. ,  LAL, Preeti, G. ,  THORNTON, Michael ,  HAFALIA, April, J.A. ,  YAO, Monique, G. ,  NGUYEN, Danniel, B. ,  GANDHI, Ameena, R. ,  KHAN, Farrah A. ,  CHAWLA, Narinder K. ,  GRIFFIN, Jennifer A. ,  CHINN, Anna M. ,  ELLIOTT, Vicki S. ,  RAMKUMAR, Jayalaxmi ,  ARVIZU, Chandra S. ,  FORSYTHE, Ian J.

IPC分类号： C07K14/00

CPC分类号： C07K14/78 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

摘要： The invention provides human cell adhesion and extracellular matrix proteins (CADEM) and polynucleotides which identify and encode CADECM. The invention also provides expression vectors, host cells, antibodies, agonists and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.

公开(公告)号：EP1387889A2

公开(公告)日：2004-02-11

申请号：EP02756071.3

申请日：2002-01-16

申请人： Incyte Genomics, Inc.

发明人： LEE, Ernestine, A. ,  CHAWLA, Narinder, K. ,  BAUGHN, Mariah, R. ,  ISON, Craig, H. ,  GURURAJAN, Rajagopal ,  ARVIZU, Chandra ,  YAO, Monique, G. ,  JACKSON, Jennifer, L. ,  TANG, Tom, Y. ,  YUE, Henry ,  TRAN, Bao ,  DING, Li ,  LU, Dyung, Aina, M. ,  LAL, Preeti, G. ,  WARREN, Bridget, A.

IPC分类号： C12N15/54

CPC分类号： C12N9/12 ,  A01K2217/05 ,  C12N9/16

摘要： The invention provides human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. The invention also provides expression vector, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.

摘要翻译： 本发明提供了识别和编码KPP的人类激酶和磷酸酶（KPP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与KPP异常表达相关的病症的方法。

公开(公告)号：EP1339834A2

公开(公告)日：2003-09-03

申请号：EP01986129.3

申请日：2001-12-04

申请人： Incyte Genomics, Inc.

发明人： TANG, Y., Tom ,  GRIFFIN, Jennifer, A. ,  YUE, Henry ,  LEE, Ernestine, A. ,  BAUGHN, Mariah, R. ,  DUGGAN, Brendan, M. ,  CHAWLA, Narinder, K. ,  LEE, Sally ,  RAMKUMAR, Jayalaxmi ,  WARREN, Bridget, A. ,  GANDHI, Ameena, R. ,  LU, Dyung, Aina, M. ,  LU, Yan ,  YAO, Monique, G. ,  DING, Li ,  TRIBOULEY, Catherine, M. ,  SANJANWALA, Madhu, M. ,  ARVIZU, Chandra ,  JACKSON, Jennifer, L.

IPC分类号： C12N9/00

CPC分类号： C12N9/88 ,  A01K2217/05

摘要： The invention provides human enzymes (NZMS) and polynucleotides which identify and encode NZMS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NZMS.

公开(公告)号：EP1419249A2

公开(公告)日：2004-05-19

申请号：EP02709433.3

申请日：2002-02-05

申请人： Incyte Genomics, Inc.

发明人： JACKSON, Jennifer, L.

IPC分类号： C12N15/12

CPC分类号： C07K14/4747

摘要： The invention provides a cDNA which encodes TIMM8b-related protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly breast cancer, ovarian cancer, and kidney cancer; and neurodegenerative disorders, particularly Mohr-Tranebjaerg syndrome, epilepsy, spasticity, and dystonia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

公开(公告)号：EP1409504A2

公开(公告)日：2004-04-21

申请号：EP02739118.4

申请日：2002-03-27

申请人： Incyte Genomics, Inc.

发明人： DAFFO, Abel ,  JONES, Anissa, L. ,  TRAN, Alanna-Phung, B. ,  DAHL, Christopher, R. ,  GIETZEN, Darryl ,  CHINN, Joyce ,  DUFOUR, Gerard, E. ,  JACKSON, Jennifer, L. ,  YU, Jimmy, Y. ,  TUASON, Olivia ,  YAP, Pierre, E. ,  AMSHEY, Stefan, R. ,  DAUGHTERY, Sean, C. ,  DAM, Tam, C. ,  LIU, Tommy, F. ,  NGUYEN, Duy-Viet, An ,  KLEEFELD, Yael ,  GERSTIN, Edward, H., Jr. ,  PERALTA, Careyna, H. ,  DAVID, Marie H. ,  LEWIS, Samantha A. ,  CHEN, Alice J. ,  PANZER, Scott R. ,  HARRIS, Bernard ,  MULLAHY-FLORES, Vincent Z. ,  MARWAHA, Rakesh ,  LO, Audrey ,  LAN, Ruth Y. ,  URASHKA, Michael E.

IPC分类号： C07H21/00

CPC分类号： C07K14/47

摘要： The invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTMto induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.