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公开(公告)号：EP0083069A3
公开(公告)日：1984-03-28
申请号：EP82111895
申请日：1982-12-22
发明人： Itoh, Seiga , Nishi, Tatsunari , Mizukami, Tamio , Matsumoto, Tadashi , Oka, Tetsuo , Taniguchi, Tadatsugu , Sugano, Haruo
CPC分类号： C07K14/565 , C12N15/71 , Y10S930/142
摘要： Disclosed are recombinant vector plasmids containing a DNA fragment coding for human interferon-β inserted downstream from a tryptophane promoter. The plasmids are useful for transformation of microorganisms such as Escherichia coli which transformants produce human interferon-β.
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2.发明公开Recombinant plasmid containing human interferon-beta gene 失效重组质粒menschliches beta-Interferon Gen enthaltend。
公开(公告)号：EP0083069A2
公开(公告)日：1983-07-06
申请号：EP82111895.7
申请日：1982-12-22
发明人： Itoh, Seiga , Nishi, Tatsunari , Mizukami, Tamio , Matsumoto, Tadashi , Oka, Tetsuo , Taniguchi, Tadatsugu , Sugano, Haruo
CPC分类号： C07K14/565 , C12N15/71 , Y10S930/142
摘要： Disclosed are recombinant vector plasmids containing a DNA fragment coding for human interferon-β inserted downstream from a tryptophane promoter. The plasmids are useful for transformation of microorganisms such as Escherichia coli which transformants produce human interferon-β.
摘要翻译： 公开了含有编码从色氨酸启动子下游插入的人干扰素-β的DNA片段的重组载体质粒。 质粒可用于转化微生物如转化体产生人干扰素-β的大肠杆菌。
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公开(公告)号：EP0083069B1
公开(公告)日：1987-09-16
申请号：EP82111895.7
申请日：1982-12-22
发明人： Itoh, Seiga , Nishi, Tatsunari , Mizukami, Tamio , Matsumoto, Tadashi , Oka, Tetsuo , Taniguchi, Tadatsugu , Sugano, Haruo
CPC分类号： C07K14/565 , C12N15/71 , Y10S930/142
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公开(公告)号：EP0249854A2
公开(公告)日：1987-12-23
申请号：EP87108303.6
申请日：1987-06-09
CPC分类号： C07K14/4705 , A61K38/00
摘要： According to the present invention, a recombinant DNA wherein a DNA coding for a novel physiologically active polypeptide produced by human erythroleukemia cell strain K562-T1 is incorporated and a microorganism or an animal cell carrying the recombinant DNA can be obtained, and they can be utilized for producing a large amount of the physiologically active polypeptide.
摘要翻译： 根据本发明，可以获得编码由人红白血病细胞株K562-T1产生的新型生理活性多肽的DNA的重组DNA，并且可以获得携带重组DNA的微生物或动物细胞，并且可以使用它们 用于产生大量的生理活性多肽。
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公开(公告)号：EP0768317B1
公开(公告)日：1999-01-27
申请号：EP96116414.2
申请日：1996-10-14
发明人： Mizukami, Tamio , Asai, Akira , Yamashita, Yoshinori , Katahira, Ritsuko , Hasegawa, Atsuhiro , Ochiai, Keiko , Akinaga, Shiro
CPC分类号： C07K5/06026 , A61K38/00
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公开(公告)号：EP0088166A2
公开(公告)日：1983-09-14
申请号：EP82112072.2
申请日：1982-12-28
发明人： Katsumata, Ryoichi , Ozaki, Akio , Mizukami, Toru , Kageyama, Motoko , Yagisawa, Morimasa , Mizukami, Tamio , Itoh, Seiga , Oka, Tetsuo , Furuya, Akira
摘要： Disclosed is a process for expressing a gene and producing a metabolic product formed by the gene by culturing a transformant microorganism carrying a recombinant DNA constructed of a DNA fragment having at least one gene to be expressed and a vector DNA, at least one of which is foreign to the host microorganism.
摘要翻译： 公开了通过培养携带由具有至少一种待表达基因的DNA片段和载体DNA构建的重组DNA的转化体微生物来表达基因并产生由该基因形成的代谢产物的方法，其中至少一种是 外来宿主微生物。
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公开(公告)号：EP0849267B1
公开(公告)日：2001-09-26
申请号：EP97122290.6
申请日：1997-12-17
发明人： Mizukami, Tamio , Ogawa, Harumi , Nakai, Ryuichiro , Asai, Akira , Yamashita, Yoshinori , Ando, Katsuhiko , Agatsuma, Tsutomu , Akinaga, Shiro , Ouchi, Kozo , Kawasaki, Hideki
IPC分类号： C07D491/16 , A61K31/40 , C07D487/04 , C12P17/14 , C12N1/14
CPC分类号： C07D487/04 , C12P17/14
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8.发明公开Herboxidiene derivatives and their preparation from streptomyces GEX1 culture 失效Herboxidien-Derivate和ihre Herstellung aus einer Streptomyces GEX1 Kultur
公开(公告)号：EP0781772A1
公开(公告)日：1997-07-02
申请号：EP96120927.7
申请日：1996-12-27
发明人： Mizukami, Tamio , Sakai, Yasushi , Yoshida, Tetsuo, , Uosaki, Youichi, , Ochiai, Keiko, , Akinaga, Shiro,
IPC分类号： C07D407/04 , C07D407/14 , C12P17/06 , A61K31/35
CPC分类号： C07D407/06 , C07D407/14 , C12P17/06
摘要： Disclosed is Compound GEX1 of formula (I), having excellent antitumor activity:
wherein R 1 represents hydroxy or
R 2 , R 3 and R 4 independently represent hydrogen or hydroxy;R 5 represents hydroxy or lower alkoxy; provided that when R 1 is hydroxy and R 5 is methoxy, then at least one of R 2 , R 3 and R 4 is not hydrogen, and pharmaceutically acceptable salts thereof.摘要翻译： 公开了具有优异抗肿瘤活性的式（I）化合物GEX1：其中R 1表示羟基或CHEM R 2，R 3和R 4分别代表氢或羟基; R 5代表羟基或低级烷氧基; 条件是当R 1是羟基且R 5是甲氧基时，R 2，R 3和R 4中的至少一个不是氢，和其药学上可接受的盐。
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公开(公告)号：EP0166444B1
公开(公告)日：1990-11-28
申请号：EP85107987.1
申请日：1985-06-27
发明人： Sekine, Susumu , Mizukami, Tamio , Sato, Moriyuki , Itoh, Seiga , Saito, Akiko
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
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公开(公告)号：EP0166444A2
公开(公告)日：1986-01-02
申请号：EP85107987.1
申请日：1985-06-27
发明人： Sekine, Susumu , Mizukami, Tamio , Sato, Moriyuki , Itoh, Seiga , Saito, Akiko
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
摘要： According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.
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