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公开(公告)号：EP1767627A4
公开(公告)日：2007-07-25
申请号：EP05749067
申请日：2005-06-07
发明人： OCHIAI ATSUSHI , SHIRAISHI NORIHIKO , KATO YOKO , OTA TOSHIO , SEKINE SUSUMU , SHITARA KENYA , FURUYA AKIKO , OHTA SO , HOSAKA EMI , SASAKI YUKA
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/32 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/28 , C07K2317/732 , C07K2317/734
摘要： It is intended to provide an antibody which specifically recognizes the stereostructure of the extracellular domain of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular domain. This antibody is useful in treating various diseases associated with the overexpression of the polypeptide encoded by PERP gene. Furthermore, this antibody makes it possible to specifically detect the polypeptide encoded by PERP gene or a cell expressing this polypeptide by an immunological procedure and, therefore, is useful in diagnosing various diseases in which PERP participates.
摘要翻译： 旨在提供一种特异性识别由PERP（PMP-22相关的p53凋亡效应子）基因编码的多肽的胞外结构域的立体结构并与细胞外结构域结合的抗体。 该抗体可用于治疗与由PERP基因编码的多肽的过表达有关的各种疾病。 此外，该抗体可以通过免疫学方法特异性检测由PERP基因编码的多肽或表达该多肽的细胞，因此可用于诊断PERP参与的各种疾病。
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2.发明公开METHOD FOR SEARCHING STEROID SULFATASE INHIBITORS 审中-公开VERFAHREN ZUR AUFFINDUNG VON STEROID SULFATASEHEMMENDE VERBINDUNGEN
公开(公告)号：EP1065281A4
公开(公告)日：2004-08-18
申请号：EP99910718
申请日：1999-03-26
申请人： KYOWA HAKKO KOGYO KK
发明人： ANAZAWA HIDEHARU , KATO YOKO , ISHIDA HIROYUKI , NAKATA TAISUKE , AKINAGA SHIRO
CPC分类号： C12Q1/34 , A01K2217/05 , C12N9/16 , G01N33/5011
摘要： A method for efficiently searching compounds capable of inhibiting steroid sulfatase activity and thus being useful in treating hormone-dependent diseases such as mammary cancer which comprises treating cells having a steroid sulfatase gene transferred thereinto with the compounds to be tested and then judging the proliferation of the cells.
摘要翻译： 一种有效地检索能够抑制类固醇硫酸酯酶活性的化合物的方法，因此可用于治疗激素依赖性疾病如乳腺癌，该方法包括用待测化合物处理其中转移有类固醇硫酸酯酶基因的细胞，然后判断 细胞。
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公开(公告)号：EP1266961A4
公开(公告)日：2004-12-08
申请号：EP01912419
申请日：2001-03-16
申请人： KYOWA HAKKO KOGYO KK
摘要： By taking out a protein (kidney repairing factor: KRGF-1) which shows an increase in expression in repairing damaged tissues in patients with kidney diseases, a DNA encoding this protein and an antibody recognizing this protein are produced. These substances are usable in searching for remedies for repairing damaged kidney tissues and diagnosing kidney failures.
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公开(公告)号：EP0960934A4
公开(公告)日：2003-09-03
申请号：EP97942199
申请日：1997-09-25
发明人： NAGASHIMA TADASHI , KUROYANAGI SATOSHI , YAMAMURA TADANORI , ANAZAWA HIDEHARU , KATO YOKO , SUGIMOTO SEIJI , YANO KEIICHI
CPC分类号： C12N9/16 , A23K20/189 , Y10S426/807
摘要： A phytase having a low Km value against phytic acid; a process for the preparation of the phytase by using a microorganism having the ability to generate and accumulate the phytase; and feed containing the phytase. The novel phytase can hydrolyze phytic acid (acting as antinutritional factor) contained in feed, which brings about an enhancement in the nutritive value of the feed, and permits the efficient utilization of phosporic acid liberated by the hydrolysis.
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公开(公告)号：EP1325959A4
公开(公告)日：2005-05-25
申请号：EP01945681
申请日：2001-06-28
IPC分类号： C07K14/37 , C12N1/19 , C12N15/80 , C12N9/04 , C12N9/06 , C12N9/14 , C12N9/16 , C12N9/36 , C12N15/11
摘要： A novel DNA encoding a selection marker and a novel DNA serving as a promoter/terminator which are appropriate for a transformation system of a fungus belonging to the genus Monascus and the expression of a recombinant DNA; and a novel transformation system of a fungus belonging to the genus Monascus wherein the monascus is transformed by a vector containing the above-described DNA encoding a selection marker and the promoter/terminator sequence together with a DNA encoding a desired protein, culturing the resultant transformant and thus obtaining the expression product of the recombinant DNA at a high level.
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公开(公告)号：EP1308509A4
公开(公告)日：2004-05-12
申请号：EP01955553
申请日：2001-08-01
申请人： KYOWA HAKKO KOGYO KK
发明人： SATOH MITSUO , SHIBATA KENJI , SEKINE SUSUMU , KOIKE MASAMICHI , SAKURAI WATARU , FURUYA AKIKO , MORI KATSUHIRO , KATO YOKO
IPC分类号： A61K38/00 , A61K48/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/02 , A61P25/02 , A61P27/06 , A61P27/14 , A61P27/16 , A61P35/00 , A61P37/06 , A61P37/08 , C07K14/47 , C07K14/52 , C12P21/08 , C12N15/09 , A61K39/00
CPC分类号： C07K14/52 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/47
摘要： A physiologically active peptide which is useful in searching for and developing remedies for diseases accompanying infection or inflammation, diseases accompanying abnormal differentiation and proliferation of smooth muscle cells, diseases accompanying abnormal activation of fibroblasts, diseases accompanying abnormal activation of synovial tissues, diseases accompanying disorders in pancreatic ss cells, diseases accompanying disorders in osteoblasts or osteoclasts, diseases accompanying abnormal activation of immunocytes, diseases accompanying vascular disorders, eye diseases based on abnormal angiogenesis, diseases accompanying abnormal cell proliferation, diseases in association with the major histocompatible antigen gene domain, etc.; DNA encoding this peptide; an antibody recognizing this peptide; and methods of using the same.
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