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公开(公告)号：EP2805157B1
公开(公告)日：2017-07-12
申请号：EP13704843.5
申请日：2013-01-18
发明人： LI, Shifeng , BUSTILLO, James , HINZ, Wolfgang
IPC分类号： G01N27/414
CPC分类号： G01N27/4145 , C12Q1/6869 , G01N27/414 , Y10T436/143333
摘要： A system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The system further includes a conductive layer disposed over the lower surface and the wall surface.
摘要翻译： 一种系统包括传感器，该传感器包括传感器垫和限定可操作地耦合到传感器垫的井的井壁结构。 井由设置在传感器垫上的下表面进一步限定。 井壁结构限定上表面并限定在上表面和下表面之间延伸的壁表面。 该系统还包括设置在下表面和壁表面上的导电层。
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2.发明公开
公开(公告)号：EP2805157A2
公开(公告)日：2014-11-26
申请号：EP13704843.5
申请日：2013-01-18
发明人： LI, Shifeng , BUSTILLO, James , HINZ, Wolfgang
IPC分类号： G01N27/414
CPC分类号： G01N27/4145 , C12Q1/6869 , G01N27/414 , Y10T436/143333
摘要： A system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The system further includes a conductive layer disposed over the lower surface and the wall surface.
摘要翻译： 一种系统包括传感器，其包括传感器垫和井壁结构，该结构限定了可操作地耦合到传感器垫的井。 该阱还由设置在传感器垫上的下表面限定。 井壁结构限定了上表面并限定了在上表面和下表面之间延伸的壁表面。 该系统还包括设置在下表面和壁表面上的导电层。
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3.发明公开ISFET SENSOR ARRAY COMPRISING TITANIUM NITRIDE AS A SENSING LAYER LOCATED ON THE BOTTOM OF A MICROWELL STRUCTURE 审中-公开WITH氮化钛ISFET阵列传感器层ON微孔结构的底部
公开(公告)号：EP2807478A1
公开(公告)日：2014-12-03
申请号：EP13702546.6
申请日：2013-01-18
发明人： BUSTILLO, James , REARICK, Todd , HINZ, Wolfgang , FIFE, Keith
IPC分类号： G01N27/414
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0877 , B01L2300/0893 , G01N27/4145
摘要： A method of fabricating a microwell in an array structure is disclosed herein. The array structure can include a plurality of field effect transistors (FETs), where each FET has a gate structure. The method can include disposing a titanium nitride (TiN) layer on at least one conductive layer coupled to the gate structure of at least one FET. A insulation layer can also be disposed on the array structure, where the insulation layer lies above the TiN layer. Further, an opening above the gate structure of the at least one FET can be etched to remove the insulation layer above the gate structure and to expose the TiN layer. A microwell with at least one sidewall formed from the insulation layer and with a bottom surface formed from the TiN layer is a result of the etching process.
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公开(公告)号：EP2807478B1
公开(公告)日：2019-07-31
申请号：EP13702546.6
申请日：2013-01-18
发明人： BUSTILLO, James , REARICK, Todd , HINZ, Wolfgang , FIFE, Keith
IPC分类号： G01N27/414 , B01L3/00
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公开(公告)号：EP4095264A1
公开(公告)日：2022-11-30
申请号：EP22185816.0
申请日：2016-03-04
发明人： WAGGONER, Phil , BALL, James , HINZ, Wolfgang , MINTO, Michael , PARKER, Scott , COX, David , MASTROIANNI, Alexander , GRAY, Jeremy , GLAZER, Marc , GORRELL, Kimberly
IPC分类号： C12Q1/6869 , G01N27/414
摘要： A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：EP3265585A1
公开(公告)日：2018-01-10
申请号：EP16711079.0
申请日：2016-03-04
发明人： WAGGONER, Phil , BALL, James , HINZ, Wolfgang , MINTO, Michael , PARKER, Scott , COX, David , MASTROIANNI, Alexander , GRAY, Jeremy , GLAZER, Marc , GORRELL, Kimberly
IPC分类号： C12Q1/68 , G01N27/414
CPC分类号： C12Q1/6869 , G01N27/4145 , C12Q2527/119 , C12Q2527/125 , C12Q2565/607
摘要： A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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7.发明公开Methods and apparatus for measuring analytes using large scale FET arrays 有权大规模方法和装置的分析物测量通过FET阵列的方法
公开(公告)号：EP2762872A1
公开(公告)日：2014-08-06
申请号：EP14152861.2
申请日：2007-12-14
IPC分类号： G01N27/414 , G01N33/543
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/42324 , H01L29/78 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101
摘要： A circuit may include an array of CMOS-fabricated pixels formed in columns and rows. Each pixel (105) includes: a chemically-sensitive field effect transistor (chemFET) (150), a first switch (Q3), and a second switch (Q2). The chemFET has a floating gate structure, a source terminal, and a drain terminal that is coupled to a first readout signal line (116). The first switch couples the source terminal of the chemFET to a current source (106) and has one first transistor. The second switch couples the source terminal of the chemFET to a second readout signal line (114) and has one second transistor. The first and second switches are controlled by a row selection line (118) coupled to the two switches.
摘要翻译： 一种电路可以包括在制造形成在列和行的CMOS像素阵列。 各像素（105）包括：化学敏感的场效应晶体管（个chemFET）（150），第一开关（Q3），和第二开关（Q2）。 所述chemFET具有浮动栅极结构，源极端子和漏极端子也被连接到第一读出信号线（116）。 第一开关耦合在chemFET的源极端子到电流源（106），并具有一个第一晶体管。 所述第二开关耦合在chemFET的源极端子到第二读出信号线（114）和具有一个第二晶体管。 第一和第二开关由耦合到两个开关的行选择线（118）控制。
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公开(公告)号：EP2321434A2
公开(公告)日：2011-05-18
申请号：EP09805290.5
申请日：2009-08-07
发明人： ROTHBERG, Jonathan, M. , LEAMON, John, H. , DAVIDSON, John, F. , VAN OIJEN, Antoine, M. , HINZ, Wolfgang , DAVEY, Melville , HANN, Bradley , SCHULTZ, Jonathan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
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公开(公告)号：EP4116338A1
公开(公告)日：2023-01-11
申请号：EP22192503.5
申请日：2013-02-08
发明人： FONNUM, Geir , MODAHL, Grete , KJUS, Nini , MOLTEBERG, Astrid Evenroed , TRAN, Diem , AASERUD, Jo , GOKMEN, M. Talha , MENCHEN, Steven , FULLER, Carl , ANDRUZZI, Luisa , HINZ, Wolfgang , GREMYACHINSKIY, Dmitriy , LIGHT, David , MASTROIANNI, Alexander , ROSENBLUM, Barnett , KHAN, Shaheer , STOLARCZYK, Craig , SOKOLSKY, Tanya
IPC分类号： C08F2/16 , C08F220/54 , C08F8/12 , C08F222/38 , C12Q1/68 , C09D5/00 , C08F2/20 , C08F2/26 , C08F230/08 , C08F257/02 , C08F220/58 , C08F220/60 , C08F8/34 , C08F130/08 , C07F7/18
摘要： A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：EP3489367B1
公开(公告)日：2020-09-09
申请号：EP18213839.6
申请日：2016-03-04
发明人： WAGGONER, Phil , BALL, James , HINZ, Wolfgang , MINTO, Michael , PARKER, Scott , COX, David , MASTROIANNI, Alexander , GRAY, Jeremy , GLAZER, Marc , GORRELL, Kimberly
IPC分类号： C12Q1/6869 , G01N27/414
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