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    AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS
    3.
    发明公开
    AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
    用于HIV整合酶抑制剂的AZA-和POLYAZA-NAPHTHALENYL酮

    公开(公告)号：EP1333831A2

    公开(公告)日：2003-08-13

    申请号：EP01990637.9

    申请日：2001-10-09

    申请人： Merck & Co., Inc.

    发明人： ZHUANG, Linghang ,  WAI, John, S. ,  PAYNE, Linda, S. ,  YOUNG, Steven, D. ,  FISHER, Thorsten, E. ,  EMBREY, Mark ,  GUARE, James, P.

    IPC分类号： A61K31/47 ,  A61K31/495 ,  C07D215/26 ,  C07D471/04

    CPC分类号： C07D215/04 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D471/04

    摘要： Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 包括某些喹啉基和萘啶酮酮的某些氮杂 - 和多氮 - 萘基酮被描述为HIV整合酶抑制剂和HIV复制抑制剂。 这些化合物可用作预防或治疗HIV感染和治疗或延迟AIDS的发作，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，任选地与其它抗病毒剂，免疫调节剂，抗生素或 疫苗。 还描述了治疗或延缓AIDS发作的方法以及预防或治疗HIV感染的方法。

    HIV INTEGRASE INHIBITORS
    6.
    发明公开
    HIV INTEGRASE INHIBITORS 有权
    HIV整合酶抑制剂

    公开(公告)号：EP1881825A2

    公开(公告)日：2008-01-30

    申请号：EP06759135.4

    申请日：2006-05-05

    申请人： Merck & Co., Inc.

    发明人： VACCA, Joseph, P. ,  WAI, John, S. ,  PAYNE, Linda, S. ,  ISAACS, Richard, C., A. ,  HAN, Wei ,  EGBERTSON, Melissa ,  PRACITTO, Richard

    IPC分类号： A61K31/40 ,  A61K31/445

    CPC分类号： C07D471/14 ,  A61K31/4353 ,  A61K31/4375 ,  C07D498/14

    摘要： Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, Rl, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译： 式（I）的三环化合物是HIV整合酶抑制剂和HIV复制抑制剂：其中键a，环A，R1，R2和R3如本文所定义。 这些化合物可用于预防或治疗HIV感染和预防，治疗或延缓AIDS发作。 这些化合物本身作为化合物或以药学上可接受的盐的形式用于抗HIV感染和AIDS。 化合物及其盐可以用作药物组合物中的成分，任选地与其他抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。