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公开(公告)号：EP2299824A1
公开(公告)日：2011-03-30
申请号：EP09763282.2
申请日：2009-06-01
IPC分类号： A01N43/56 , A61K31/415
CPC分类号： C07D471/04 , C07D231/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10
摘要： The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease
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公开(公告)号：EP1496838B1
公开(公告)日：2010-11-03
申请号：EP03714051.4
申请日：2003-03-07
发明人： HAGMANN, William, K. , LIN, Linus, S. , SHAH, Shrenik, K. , GUTHIKONDA, Ravindra, N. , QI, Hongbo , CHANG, Linda, L. , LIU, Ping , ARMSTRONG, Helen, M. , JEWELL, James, P. , LANZA, Thomas, J., Jr.
IPC分类号： C07C233/05 , C07D213/02 , C07D213/62 , C07D401/02 , A61K31/165 , A61K31/44 , A61K31/505
CPC分类号： C07D213/64 , C07C233/13 , C07C235/06 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/34 , C07D209/94 , C07D211/34 , C07D213/65 , C07D213/68 , C07D215/06 , C07D231/12 , C07D233/56 , C07D233/70 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D263/58 , C07D267/14 , C07D277/30 , C07D277/36 , C07D295/13 , C07D295/15 , C07D513/04
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
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公开(公告)号：EP3082786A1
公开(公告)日：2016-10-26
申请号：EP14870903.3
申请日：2014-12-17
发明人： HAGMANN, William, K. , LI, Bing , SZEWCZYK, Jason, W. , WANG, Bowei , PARKER, Dann , BLIZZARD, Timothy , JOSIEN, Hubert , BIJU, Purakkattle , CHOBANIAN, Harry , GUDE, Candido , NARGUND, Ravi, P. , PIO, Barbara , DANG, Qun , LIN, Linus, S. , HU, Bin , CUI, Mingxiang , CHEN, Zhengxia , DAI, Meibi , ZHANG, Zaihong , LV, Ying , TIAN, Lili
IPC分类号： A61K31/192 , A61K31/381
CPC分类号： C07D493/04 , A61K31/437 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/46 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/64 , C07D213/74 , C07D221/20 , C07D239/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D451/06 , C07D471/04
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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公开(公告)号：EP2321288B1
公开(公告)日：2014-03-19
申请号：EP09790960.0
申请日：2009-07-30
发明人： CHOBANIAN, Harry , LIN, Linus, S. , LIU, Ping , CHIODA, Marc, D. , DEVITA, Robert, J. , NARGUND, Ravi, P. , GUO, Yan
IPC分类号： C07D263/46 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/4427 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/506 , A61P25/00 , A61P19/00
CPC分类号： C07D413/14 , C07D263/46 , C07D271/06 , C07D271/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14
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公开(公告)号：EP2299824B1
公开(公告)日：2013-06-19
申请号：EP09763282.2
申请日：2009-06-01
IPC分类号： A61K31/4155 , A61P19/02 , A61P25/00 , C07D231/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10 , C07D471/04
CPC分类号： C07D471/04 , C07D231/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10
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公开(公告)号：EP3974413A1
公开(公告)日：2022-03-30
申请号：EP21202075.4
申请日：2014-12-17
发明人： HAGMANN, William K. , LI, Bing , SZEWCZYK, Jason, W. , WANG, Bowei , PARKER, Dann , BLIZZARD, Timothy , JOSIEN, Hubert , BIJU, Purakkattle , CHOBANIAN, Harry , GUDE, Candido , NARGUND, Ravi, P. , PIO, Barbara , DANG, Qun , LIN, Linus, S. , HU, Bin , CUI, Mingxiang , CHEN, Zhengxia , DAI, Meibi , ZHANG, Zaihong , LV, Ying , TIAN, Lili
IPC分类号： C07D213/64 , C07D213/74 , C07D221/20 , C07D239/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D451/06 , C07D471/04 , C07D493/04 , A61K31/437 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/505
摘要： The present invention relates to a compound represented by formula I:
and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.-
7.发明授权IMIDAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH AND AS FAAH IMAGING AGENTS 有权咪唑衍生物可用作FAAH调节剂和FAAH成像剂
公开(公告)号：EP2403338B1
公开(公告)日：2017-07-26
申请号：EP10749107.8
申请日：2010-02-22
发明人： LIU, Ping , DEVITA, Robert, J. , LIN, Linus, S. , CHIODA, Marc, D. , HAMILL, Terence, G. , LI, Wenping
IPC分类号： C07D401/14 , C07D413/14 , C07D401/12 , C07D413/10 , A61K31/415
CPC分类号： C07D401/12 , C07D401/14 , C07D413/10 , C07D413/14
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公开(公告)号：EP1575901B1
公开(公告)日：2012-10-10
申请号：EP03814048.9
申请日：2003-12-15
IPC分类号： C07C233/05 , C07D213/02 , A61K31/44
CPC分类号： C07D213/64 , C07C255/60 , C07C275/24 , C07C2601/04
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9.发明公开IMIDAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH AND AS FAAH IMAGING AGENTS 有权咪唑衍生物AS FAAH调制器和AS FAAH造影剂
公开(公告)号：EP2403338A1
公开(公告)日：2012-01-11
申请号：EP10749107.8
申请日：2010-02-22
发明人： LIU, Ping , DEVITA, Robert, J. , LIN, Linus, S. , CHIODA, Marc, D. , HAMILL, Terence, G. , LI, Wenping
IPC分类号： A01N43/50 , A01N43/52 , A61K31/415
CPC分类号： C07D401/12 , C07D401/14 , C07D413/10 , C07D413/14
摘要： The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
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公开(公告)号：EP2300438A1
公开(公告)日：2011-03-30
申请号：EP09763316.8
申请日：2009-06-04
发明人： LIN, Linus, S. , CHIODA, Marc, D. , LIU, Ping , NARGUND, Ravi, P.
IPC分类号： C07D233/00
CPC分类号： A61K31/4174 , A61K31/4178 , C07D233/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/14
摘要： The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
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