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1.发明授权
公开(公告)号：EP2953462B1
公开(公告)日：2020-04-08
申请号：EP14749686.3
申请日：2014-02-03
发明人： HE, Shuwen , DAI, Xing , PALANI, Anandan , NARGUND, Ravi , LAI, Zhong , ZORN, Nicolas , XIAO, Dong , DANG, Qun , LI, Peng , PENG, Xuanjia , SOLL, Richard
IPC分类号： A61K31/5377 , A61K31/5365 , C07D498/14 , A61P31/14
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公开(公告)号：EP3204363A1
公开(公告)日：2017-08-16
申请号：EP15849713.1
申请日：2015-10-08
发明人： UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , CRESPO, Alejandro , WANG, Ming , CHEN, Yili , CAI, Jiaqiang , WU, Fan , DU, Xiaoxing
IPC分类号： C07D239/26
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP2758058B1
公开(公告)日：2017-04-26
申请号：EP12833964.5
申请日：2012-09-19
发明人： DANG, Qun , ZHOU, Changyou , ZOU, Wuxin , HUA, Yuxia
IPC分类号： C07D239/32 , C07D239/42 , C07D413/04 , C07D413/12 , A61K31/505 , A61P7/06
CPC分类号： C07F9/65583 , C07D239/32 , C07D239/36 , C07D239/47 , C07D413/04 , C07D413/12 , C07F9/65127
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公开(公告)号：EP3082786A1
公开(公告)日：2016-10-26
申请号：EP14870903.3
申请日：2014-12-17
发明人： HAGMANN, William, K. , LI, Bing , SZEWCZYK, Jason, W. , WANG, Bowei , PARKER, Dann , BLIZZARD, Timothy , JOSIEN, Hubert , BIJU, Purakkattle , CHOBANIAN, Harry , GUDE, Candido , NARGUND, Ravi, P. , PIO, Barbara , DANG, Qun , LIN, Linus, S. , HU, Bin , CUI, Mingxiang , CHEN, Zhengxia , DAI, Meibi , ZHANG, Zaihong , LV, Ying , TIAN, Lili
IPC分类号： A61K31/192 , A61K31/381
CPC分类号： C07D493/04 , A61K31/437 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/46 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/64 , C07D213/74 , C07D221/20 , C07D239/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D451/06 , C07D471/04
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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5.发明授权
公开(公告)号：EP2362731B1
公开(公告)日：2016-04-06
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A61K31/366 , C07F9/6506 , C07F9/6574 , A61K31/415 , A61K31/397 , A61K31/4184 , A01N43/50 , A61K31/4412 , A61K45/06 , C07F9/6558
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
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6.发明公开2'-DISUBSTITUTED SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开2'-核苷二取代AND METHOD FOR其用于病毒病的治疗
公开(公告)号：EP2909210A1
公开(公告)日：2015-08-26
申请号：EP13847502.5
申请日：2013-10-11
IPC分类号： C07D487/04 , A61K31/5025 , A61P31/12
CPC分类号： A61K31/706 , A61K31/7056 , A61K38/21 , A61K45/06 , C07D487/04 , C07H7/06 , A61K2300/00
摘要： 2'-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed:(1), wherein A is N
3 or NH
2 and X, Y, R
1 , R
2 , R
3 , R
4 ,R
5 and R
18 are as defined herein. Compositions comprising at least one 2'-disubstituted nucleoside derivative, and methods of using the 2'-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.-
7.发明公开
公开(公告)号：EP2362731A1
公开(公告)日：2011-09-07
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A01N43/50 , A61K31/415 , C07D243/08
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP2706852B1
公开(公告)日：2018-08-22
申请号：EP12782391.2
申请日：2012-05-04
发明人： DESCHENES, Denis , ALTMAN, Michael D. , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , SCHELL, Adam J. , SMITH, Graham F. , TAOKA, Brandon M. , BIENSTOCK, Corey , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , PETERSON, Scott , SPENCER, Kerrie B. , JEWELL, James Patrick , ALI, Amjad , BENNETT, David Jonathan , DANG, Qun , WAI, John
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
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公开(公告)号：EP3209667A1
公开(公告)日：2017-08-30
申请号：EP15853228.3
申请日：2015-10-21
发明人： YOUNG, Katherine , OLSEN, David B. , SINGH, Sheo B. , SU, Jing , WILKENING, Robert R. , APGAR, James M. , MENG, Dongfang , PARKER, Dann , MANDAL, Mihir , YANG, Lihu , PAINTER, Ronald E. , DANG, Qun , SUZUKI, Takao
IPC分类号： C07D493/10
CPC分类号： C07D493/08 , C07C53/18 , C07C309/06 , C07D493/18 , C07D519/00 , C07F7/1856
摘要： The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against Mycobacterium tuberculosis. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.
摘要翻译： 本发明涉及新的可以抑制DnaE并具有抗细菌特别是抗结核分枝杆菌的抗分枝杆菌活性的Nargenicin相关化合物。 本发明还涉及抑制分枝杆菌细胞生长的方法以及通过施用抗分枝杆菌有效量的Nargenicin或Narragein相关化合物和/或其药学上可接受的盐来治疗结核分枝杆菌的分枝杆菌感染的方法。
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10.发明公开
公开(公告)号：EP3204385A1
公开(公告)日：2017-08-16
申请号：EP15848373.5
申请日：2015-10-08
发明人： UJJAINWALLA, Fez , TAN, John Qiang , DANG, Qun , SINZ, Christopher J. , WANG, Ming , CHEN, Yili , CAI, Jiaqiang
IPC分类号： C07D471/20 , C07D401/14 , C07D471/04
CPC分类号： C07D239/36 , A61P7/06 , C07D413/06
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物，它们用于增强促红细胞生成素的内源产生的用途，以及用于治疗与促红细胞生成素内源性产生减少有关的疾病如贫血等疾病的药物组合物，以及包含这种化合物 和药物载体。
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