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公开(公告)号：EP0983267A4
公开(公告)日：2001-04-11
申请号：EP98911480
申请日：1998-03-04
申请人： MONSANTO CO
发明人： HEINTZ ROBERT M , GETMAN DANIEL P , MCDONALD JOSEPH J , DECRESCENZO GARY A , HOWARD SUSAN C , ABBAS S ZAHEER
IPC分类号： C07D249/12 , A61K31/18 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/423 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/02 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/46 , C07C323/67 , C07D207/08 , C07D209/18 , C07D209/48 , C07D211/14 , C07D211/22 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D233/42 , C07D233/64 , C07D235/28 , C07D239/38 , C07D239/93 , C07D241/12 , C07D257/04 , C07D263/46 , C07D263/58 , C07D265/30 , C07D271/10 , C07D277/20 , C07D277/24 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/78 , C07D285/08 , C07D285/125 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/18 , C07D307/38 , C07D307/64 , C07D307/68 , C07D307/79 , C07D309/12 , C07D317/56 , C07D317/62 , C07D333/18 , C07D333/34 , C07D333/38 , C07D333/54 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04 , H04N7/088
CPC分类号： C07C311/46 , C07D213/42 , C07D213/82 , C07D295/13 , C07D309/12 , C07D417/12
摘要： An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
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公开(公告)号：EP0984959A4
公开(公告)日：2001-05-02
申请号：EP98910177
申请日：1998-03-04
申请人： MONSANTO CO
发明人： FRESKOS JOHN N , BOEHM TERRI L , MISCHKE BRENT V , HEINTZ ROBERT M , MCDONALD JOSEPH J , DECRESCENZO GARY A , HOWARD SUSAN C
IPC分类号： C07D211/62 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K45/00 , A61P1/04 , A61P1/14 , A61P7/02 , A61P7/04 , A61P7/08 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C317/22 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/65 , C07D207/16 , C07D207/404 , C07D211/10 , C07D211/46 , C07D211/52 , C07D211/60 , C07D211/64 , C07D211/96 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/02 , C07D217/26 , C07D233/60 , C07D233/84 , C07D233/90 , C07D235/08 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D241/12 , C07D249/12 , C07D263/32 , C07D263/46 , C07D263/54 , C07D263/56 , C07D263/58 , C07D277/20 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/62 , C07D277/66 , C07D277/70 , C07D277/74 , C07D277/76 , C07D295/08 , C07D295/14 , C07D295/15 , C07D307/56 , C07D307/68 , C07D309/08 , C07D317/62 , C07D317/64 , C07D333/18 , C07D333/36 , C07D333/38 , C07D333/40 , C07D333/54 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D491/056 , C07D491/113 , C07D493/10 , A61K31/455 , A61K31/535
CPC分类号： C07D213/30 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/16 , C07D211/62 , C07D213/82 , C07D295/15
摘要： An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
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