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公开(公告)号：EP1987137B1
公开(公告)日：2011-06-22
申请号：EP07710612.8
申请日：2007-02-09
发明人： PACCALET, Thomas , BARDOR, Muriel , RIHOUEY, Christophe , GOMORD, Véronique , FAYE, Loïc , LEROUGE, Patrice , AQUIN, Stéphanie , VEZINA, Louis-Philippe , D'AOUST, Marc-André
IPC分类号： C12N15/82 , C12N15/54 , C12N15/60 , C12N5/04 , C12N5/10 , C12N9/88 , C12N9/90 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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公开(公告)号：EP1987137A1
公开(公告)日：2008-11-05
申请号：EP07710612.8
申请日：2007-02-09
发明人： PACCALET, Thomas , BARDOR, Muriel , RIHOUEY, Christophe , GOMORD, Véronique , FAYE, Loïc , LEROUGE, Patrice , AQUIN, Stéphanie , VEZINA, Louis-Philippe , D'AOUST, Marc-André
IPC分类号： C12N5/10 , A01H1/00 , A01H5/00 , A01H5/10 , A61K38/14 , C12N15/54 , C12N15/60 , C12N15/82 , C12N5/04 , C12N9/88 , C12N9/90 , C12P19/02 , C12P21/00 , C12N9/10
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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3.发明授权
公开(公告)号：EP2089526B1
公开(公告)日：2013-03-13
申请号：EP07859279.7
申请日：2007-11-08
发明人： GOMORD, Véonique , SAINT-JORE-DUPAS, Claude , BOULAFLOUS, Aurelia , KIEFFER-MEYER, Marie-Christine , FAYE, Loïc
IPC分类号： C12N15/82
CPC分类号： C12N15/8221 , C12N15/8257
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4.发明公开
公开(公告)号：EP2089526A2
公开(公告)日：2009-08-19
申请号：EP07859279.7
申请日：2007-11-08
发明人： GOMORD, Véonique , SAINT-JORE-DUPAS, Claude , BOULAFLOUS, Aurelia , KIEFFER-MEYER, Marie-Christine , FAYE, Loïc
IPC分类号： C12N15/82
CPC分类号： C12N15/8221 , C12N15/8257
摘要： The present invention provides new tools useful for controlling the post-translational modifications of recombinant polypeptides. These tools are particular signal peptides allowing the targeting of recombinant polypeptides during their synthesis in a host cell to specific sub-cellular compartments and a specific designing of said recombinant polypeptides within said sub-cellular compartments. These signal peptides are SEQ IDn-1 to SEQ IDn -31 disclosed herein. The present invention allows advantageously, for example, to increase the yield of production of a recombinant polypeptides, to prevent immunogenicity of recombinant polypeptides and to obtain therapeutically active recombinant polypeptides that are the exact copy of their natural counterpart. This invention relates particularly to the field of reorientation of plants made pharmaceuticals (PMP).
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