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1.发明授权NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 有权NUKLEOSIDDERIVATE ALS INHIBITOREN VON RNA-ABHÄNGIGERRNA VIRALPOLYMERASE
公开(公告)号：EP1355916B1
公开(公告)日：2007-01-10
申请号：EP02709299.8
申请日：2002-01-18
发明人： CARROLL, Steven, S. , MACCOSS, Malcolm , OLSEN, David, B. , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip Dan , ELDRUP, Anne, B. , PRAKASH, Thazha, P. , PRHAVC, Marija , SONG, Quanlai
IPC分类号： C07H19/14 , A61K31/7064 , A61P31/14
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译： 本发明提供了核苷化合物，其是RNA依赖性RNA病毒聚合酶的抑制剂，与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合，可用于治疗HCV感染。
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2.发明公开NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 有权核苷AS RNA依赖的RNA病毒聚合酶的抑制剂
公开(公告)号：EP1355916A2
公开(公告)日：2003-10-29
申请号：EP02709299.8
申请日：2002-01-18
发明人： CARROLL, Steven, S. , MACCOSS, Malcolm , OLSEN, David, B. , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip Dan , ELDRUP, Anne, B. , PRAKASH, Thazha, P. , PRHAVC, Marija , SONG, Quanlai
IPC分类号： C07H19/14 , A61K31/7064 , A61P31/14
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
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公开(公告)号：EP0716604B1
公开(公告)日：2005-03-16
申请号：EP94927361.9
申请日：1994-08-31
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H23/00 , C07J43/003 , C07J51/00 , C12N9/0069 , C12N15/113 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
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4.发明授权NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS 失效低聚物磷酸酯和PHOSPHORTHIOAMIDATVERBINDUNGEN
公开(公告)号：EP0751948B1
公开(公告)日：2002-09-25
申请号：EP95912595.6
申请日：1995-02-23
摘要： Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step or during a coupling step.
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公开(公告)号：EP0777678B1
公开(公告)日：1999-10-13
申请号：EP95911848.0
申请日：1995-02-22
发明人： COOK, Phillip Dan , KIELY, John , SPRANKLE, Kelly
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
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公开(公告)号：EP0656790A1
公开(公告)日：1995-06-14
申请号：EP93907292.0
申请日：1993-03-05
发明人： COOK, Phillip Dan , BRUICE, Thomas , GUINOSSO, Charles John , KAWASAKI, Andrew Mamoru , GRIFFEY, Richard
IPC分类号： A61K31 , A61K48 , A61P31 , A61P43 , C07H19 , C07H21 , C07H23 , C07J43 , C07K14 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K38
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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公开(公告)号：EP0716604A1
公开(公告)日：1996-06-19
申请号：EP94927361.0
申请日：1994-08-31
IPC分类号： C12N15 , A01N43 , C07C323 , C07H19 , C07H21 , C07H23 , C07J1 , C07J31 , C07J43 , C07J51 , C07K9 , C12N9 , C12Q1 , A61K38 , A61K48
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H23/00 , C07J43/003 , C07J51/00 , C12N9/0069 , C12N15/113 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the alkylthio group.
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8.发明公开
公开(公告)号：EP0689460A1
公开(公告)日：1996-01-03
申请号：EP93906159.0
申请日：1993-02-19
CPC分类号： C07D473/00 , A61K38/00 , C07D473/34 , C07F7/1856 , C07F9/65616 , C07H21/00 , C12N15/113 , C12N15/1133 , C12N15/1137 , C12N2310/323 , C12Y113/11012
摘要： Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics, therapeutics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.
摘要翻译： 制备包含多个通过连接部分共价连接的环丁基部分的寡核苷酸替代物并将其用作反义诊断剂，治疗剂和研究试剂。 公开了合成和使用寡核苷酸替代物及其中间体的方法。
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