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    PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND
    4.
    发明公开
    PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND 有权
    VERFAHREN ZUR HERSTELLUNG EINER NUKLEOSIDVERBINDUNG

    公开(公告)号：EP1338654A1

    公开(公告)日：2003-08-27

    申请号：EP01980986.2

    申请日：2001-11-06

    申请人： Mitsui Chemicals, Inc.

    发明人： ARAKI, Tadashi ,  IKEDA, Ichiro ,  TAKAHASHI, Katsuyuki ,  ITO, Kiyoshi ,  ASANO, Tamotsu ,  NIKUMARU, Seiya ,  NAKAMURA, Takeshi ,  ISHIBASHI, Hiroki ,  NAGAHARA, Kiyoteru ,  FUKUIRI, Yasushi

    IPC分类号： C12P19/38

    CPC分类号： C12P19/38

    摘要： In reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in an aqueous reaction medium in the presence-of a metal cation to produce a nucleoside compound, the timing or method of addition of at least one of these components to the aqueous reaction medium is varied; thereby, a nucleoside compound can be produced at a high yield efficiently without inviting the high viscosity or solidification of the reaction mixture, even when the above components are used in such amounts that the reaction mixture becomes highly viscous or is solidified when the components are used without the above variation of the addition timing or method. Thus, there can be provided a process for producing a nucleoside compound, which comprises a step of reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in the presence of nucleoside phosphorylase activity, which gives a nucleoside compound at an improved conversion, and which has wide applicability.

    摘要翻译： 在金属阳离子存在下，在水性反应介质中使戊糖-1-磷酸与核酸碱基或核酸碱基类似物反应以产生核苷化合物，添加这些中的至少一种的时间或方法 改变水性反应介质的组分; 因此，即使当使用上述成分使得当使用组分时反应混合物变得高粘稠或固化的量，可以高效率地生产核苷化合物而不引起反应混合物的高粘度或固化 而没有上述添加时间或方法的变化。 因此，可以提供一种制备核苷化合物的方法，其包括在核苷磷酸化酶活性存在下使戊糖-1-磷酸与核酸碱基或核酸碱基类似物反应的步骤，得到核苷化合物 改进后，具有广泛的适用性。